A5019616856- Dental Implant Techniques and Outcomes
- Reconstructive Surgery and Microvascular Techniques
- Dental Radiography and Imaging
- Oral health in cancer treatment
- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Reconstructive Facial Surgery Techniques
- Head and Neck Cancer Studies
- Facial Nerve Paralysis Treatment and Research
- Dental materials and restorations
- Facial Trauma and Fracture Management
- Orthodontics and Dentofacial Orthopedics
- Bone health and treatments
- Periodontal Regeneration and Treatments
- dental development and anomalies
- Bone and Joint Diseases
- Cleft Lip and Palate Research
- 3D Printing in Biomedical Research
- Oral microbiology and periodontitis research
- Bone fractures and treatments
- Head and Neck Surgical Oncology
- COVID-19 Clinical Research Studies
- Bone and Dental Protein Studies
- Bone Metabolism and Diseases
- Drug-Induced Adverse Reactions
Charité - Universitätsmedizin Berlin
2016-2025
Freie Universität Berlin
2018-2025
Humboldt-Universität zu Berlin
2018-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2024
University of Freiburg
2023
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
2021-2022
Dental peri-implantitis is characterized by a multifactorial etiology. The role of metal elements as an etiological factor for still unclear. aim this study was to investigate the incidence in bone and mucosal tissues around dental Grade 4 CP titanium implants with signs human patients.In prospective pilot study, all patients were enrolled consecutively two centers. Bone soft tissue samples indication explantation analyzed different (Ca, P, Ti, Fe) means synchrotron radiation X-ray...
Reactivation of the varicella-zoster virus (VZV), which causes herpes zoster (HZ, synonym: shingles) in humans, can be a rare adverse reaction to vaccines. Recently, reports cases after COVID-19 vaccination have arisen.The aim this study was assess whether frequency HZ is found increase large cohort, based on real-world data. As hypothesis, incidence assumed significantly higher subjects who received vaccine (Cohort I) vs. unvaccinated individuals II).The initial cohorts 1 095 086 vaccinated...
Optical impressions of implants in the edentulous arch are challenged by absence distinct surface morphology between multiple implant scan bodies. The purpose this vitro study was to evaluate a newly developed aid various designs and colors improve accuracy multi-implant scans.A universal three different (circular, square, irregular) materials (colors: beige, gray, white) applied bodies master model six an maxilla. Ten scans using intra-oral scanner each were acquired. Reference scanning...
Intraoral scans of multiple implants in the edentulous arch are challenged by absence a distinct surface morphology between scan bodies. A aid was applied such situation and evaluated for intraoral scanning accuracy vivo.87 22 patients were scanned with (SA) without (NO) using two different scanners (CS3600 [CS] TRIOS3 [TR]). Master casts digitized laboratory scanner. Virtual models superimposed an inspection software Linear deviation precision measured. Statistical analysis performed linear...
Jawbone differs from other bones in many aspects, including its developmental origin and the occurrence of jawbone-specific diseases like MRONJ (medication-related osteonecrosis jaw). Although there is a strong need, adequate vitro models this unique environment are sparse to date. While previous approaches reliant e.g. on scaffolds or spheroid culture, 3D bioprinting enables free-form fabrication complex living tissue structures. In present work, production human jawbone was realised via...
Background This study was conducted to evaluate the feasibility, clinical outcomes, and accuracy of patient-specific 3D-printed miniplates for mandible reconstruction with fibula free flaps. Methods A feasibility 8 patients. Following virtual planning, 1.0 mm titanium non-locking were produced via laser selective melting. cutting drilling guides used segmental resection flap harvesting. Flap fixation performed two 4-hole 2.0 screws (screw length 7 mm) each intersegmental gap. Clinical...
Introduction: Onset of oral lichenoid lesions (OLL) or lichen planus (OLP) can be rare adverse reactions to vaccines. Recently, the first solitary cases were reported after COVID-19 vaccination. The aim present study was assess if an increased frequency OLL/OLP found vaccination within a large real-world cohort. It assumed that incidence significantly higher in subjects who received vaccine (cohort I) compared individuals not vaccinated II). Patients and Methods: Initial cohorts 274,481...
Reconstruction of segmental bone defects by autologous grafting is still the standard care but presents challenges including anatomical availability and potential donor site morbidity. The process 3D bioprinting, application printing for direct fabrication living tissue, opens new possibilities highly personalized tissue implants, making it an appealing alternative to grafts. One most crucial hurdles clinical bioprinting choice a suitable cell source, which should be minimally invasive, with...
The study aim is a comparative proteome-based analysis of different autologous bone entities (alveolar [AB], iliac cortical [IC] bone, and spongiosa [IS]) used for alveolar onlay grafting.Site-matched samples AB, IC, IS were harvested during grafting. Proteins extracted using detergent-based (sodium dodecyl sulfate) strategy trypsinized. Proteome was performed liquid chromatography-tandem mass spectrometry (LC-MS/MS). MaxQuant peptide-to-spectrum matching, peak detection, quantitation....
Adult-onset Still's disease (AOSD) is a multi-system, auto-inflammatory characterized by fever, arthralgia, typical rash, leukocytosis, sore throat, and liver dysfunction, among other symptoms. Retrospective studies about the frequencies of AOSD have shown that this very rare. However, there has been an increased scientific interest in last 2 years, as numerous case on published. These describe occurrence after SARS-CoV-2 infection and/or COVID-19 vaccination.We analyzed incidence to examine...
BackgroundCurrent segmentation approaches for radiation treatment planning in head and neck cancer patients (HNCP) typically consider the entire mandible as an organ at risk, while of maxilla remains uncommon. Accurate risk assessment osteoradionecrosis (ORN) or implant-based dental rehabilitation after therapy may require a nuanced analysis dose distribution specific mandibular maxillary segments. Manual is time-consuming inconsistent, there no definition jaw subsections.Materials...
Objective In the multimodal treatment of advanced head and neck malignancies, primary free flap reconstruction in a one stage procedure with tumor resection is frequently combined adjuvant radiotherapy. Radiotherapy known to exhibit side effects on transplanted flaps, including osteoradionecrosis (ORN) native bone. This study aims evaluate therapeutic outcomes potential predictors ORN within osseous flaps based large-scale, single-center database. Methods A retrospective analysis was...
ABSTRACT Reconstruction of critical‐size bone defects (CSDs) with complex defect morphologies remains clinically challenging. The desire to avoid autograft harvesting has prompted an increasing quest for adequate synthetic grafting materials. clinical success rates, which have been achieved bioactive β‐tricalcium phosphate granules (TCP‐G) demonstrate that these materials become excellent alternative graft choice. In order improve surgical handling properties, TCP‐G combined natural polymers...