A5079779137- Endoplasmic Reticulum Stress and Disease
- Toxin Mechanisms and Immunotoxins
- Heat shock proteins research
- Poxvirus research and outbreaks
- Bacteriophages and microbial interactions
- Virus-based gene therapy research
- Pancreatic function and diabetes
- Autophagy in Disease and Therapy
- Service-Learning and Community Engagement
- Ethics in Business and Education
- Extracellular vesicles in disease
- Microtubule and mitosis dynamics
- Education and Critical Thinking Development
- History of Science and Natural History
- Renal and related cancers
- History of Science and Medicine
- Immunotherapy and Immune Responses
- Management and Marketing Education
- Mitochondrial Function and Pathology
- Bacillus and Francisella bacterial research
- Historical Studies and Socio-cultural Analysis
- Phagocytosis and Immune Regulation
- Cellular Mechanics and Interactions
- Educational Assessment and Pedagogy
- Transgenic Plants and Applications
St. Jude Children's Research Hospital
2005-2024
University of North Carolina at Pembroke
2017-2019
Robarts Clinical Trials
2005
Western University
2003
University of Guelph
1999-2000
In response to terminal differentiation signals that enable B cells produce vast quantities of antibodies, a dramatic expansion the secretory pathway and corresponding increase in molecular chaperones folding enzymes aid monitor immunoglobulin synthesis occurs. Recent studies reveal unfolded protein (UPR), which is normally activated by endoplasmic reticulum (ER) stress, plays critical role this process. Although activate all three branches UPR pharmacological inducers pathway, plasma cell...
ABSTRACT Subversion or appropriation of cellular signal transduction pathways is a common strategy employed by viruses to promote an environment within infected cells that supports the viral replicative cycle. Using subsets 3T3 murine fibroblasts previously shown differ in their ability support myxoma virus (MV) replication, we investigated role host serine-threonine kinases (STKs) as potential mediators permissive phenotype. Both and nonpermissive supported equivalent levels virion binding,...
A wide range of chemotherapeutic agents has been identified that are active against solid tumors. However, resistance remains an important obstacle to the development curative regimens. Whereas much attention paid acquired drug resistance, a variety physiological pathways also have described reduce sensitivity previously untreated tumors cytotoxic antitumor agents. Treatment cells with pharmacological alter environment endoplasmic reticulum (ER) and activate unfolded protein response (UPR)...
BiP co-chaperones ERdj4, ERdj5, and GRP170 associate in cells with peptides predicted to be aggregation prone. Here, extending these findings a full-length protein, we examine two Interstitial Lung Disease-associated mutants (ILD) of surfactant protein C (SP-C). The TANGO algorithm, which identifies sequences prone formation β strand aggregates, found three such regions SP-C: the N-terminal transmembrane (TM) domain sites intermolecular chaperone BRICHOS domain. We show ILD disrupt...
GRP170, a product of the
Background The unfolded protein response (UPR) is regulated by three ER-localized, transmembrane signal transducers that control distinct aspects of the UPR. We previously reported both increased resistance to etoposide and a reduction in Topoisomerase IIα levels were direct UPR activation, latter occurred independent changes Topo mRNA levels. have now examined contribution each up-stream UPR, as well some their downstream targets affecting decreased expression drug resistance. Principal...
Pediatric osteosarcomas (OS) exhibit extensive genomic instability that has complicated the identification of new targeted therapies. We found vast majority 108 patient tumor samples and patient-derived xenografts (PDXs), which display an unusually dilated endoplasmic reticulum (ER), have reduced expression four COPII vesicle components trigger aberrant accumulation procollagen-I protein within ER. CRISPR activation technology was used to increase two these, SAR1A SEC24D, physiological...
GRP170 (
Interviews are a critical component of assessing candidate’s fit in an organization. Students aspiring to be managers or human resource professionals will need complete interview successfully gain employment and then, turn, responsible for conducting interviews effectively ascertain the capabilities motivation job candidates. The service-learning experience presented here offers students competitive advantage when competing against peers limited openings. This article outlines aimed at...
This article provides an overview of job design and offers experiential teaching exercise to help students develop a better comprehension redesign, as well learn the importance challenges such undertakings. Understanding core elements is especially important because serves foundational block for deeper understanding application other organizational phenomenon characteristics model. intended introductory undergraduate graduate-level human resource management course any courses covering...
Antibody monomers are produced from two immunoglobulin heavy chains and light that folded assembled in the endoplasmic reticulum This process is assisted monitored by components of quality control machinery; an outcome made more fraught unusual genetic machinations employed to produce a seemingly unlimited antibody repertoire. Proper functioning adaptive immune system as dependent on success this operation, it ability identify degrade those molecules fail reach their native state. In study,...