A5057587563- Bioactive Compounds and Antitumor Agents
- Synthesis and biological activity
- Liver Disease Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Phytochemicals and Medicinal Plants
- Apelin-related biomedical research
- Pharmacological Effects of Natural Compounds
- Sulfur Compounds in Biology
- Peptidase Inhibition and Analysis
- Chemotherapy-induced organ toxicity mitigation
- Medicinal Plants and Neuroprotection
- Magnolia and Illicium research
- Hepatitis B Virus Studies
- Sesame and Sesamin Research
- Synthesis of Organic Compounds
- Plant Virus Research Studies
- Aluminum toxicity and tolerance in plants and animals
- MicroRNA in disease regulation
- Click Chemistry and Applications
- Neonatal Health and Biochemistry
- Medicinal plant effects and applications
- Hibiscus Plant Research Studies
- Diet, Metabolism, and Disease
- Fungal Plant Pathogen Control
- Free Radicals and Antioxidants
Modern University for Information and Technology
2020-2025
Ain Shams University
2002-2015
Abstract Objective This study evaluated hepatoprotective effect of aescin (AES) and diosmin (DIO), individually or in low-dose combination chemically induced liver injury rats. Rats were divided into 6 groups; Group 1, control, 2, injected with a single dose mixture corn oil carbon tetrachloride (CCl 4 ) to induce hepatic toxicity. Before CCl injection, Groups 3–6 treated daily for 14 days silymarin (SIL) (200 mg/kg), (AES; 3.6 & 1.75 Diosmin (DIO; 100 50 mg/kg). Serum samples analyzed...
Hawthorn (HAW) is a herbal preparation extracted from Crataegus oxyacantha. HAW has cardioprotective, antioxidants, anti-inflammatory, and anti-hypotensive effects. HAW’s effect on hepatic fibrosis remains, however, unknown. This study evaluated the impact of carbon tetrachloride (CCl4)-induced in rats elucidated its mechanisms. reduced liver index serum enzyme markers damage, as confirmed by histopathological scoring hematoxylin-eosin staining. Collagen deposition was group compared to CCl4...
Naturally occurring phytochemicals especially polyphenolic compounds have received increasing attention as chemopreventive agents. The potential of the ethanolic extract Salvadora persica L. fruits SP, (the arak tree or miswak) on 7,12-dimethylbenz (a) anthracene (DMBA)-induced mammary carcinogenesis in female albino rats was investigated this work. Ethanolic SP supplemented to experimental groups at a concentration 500 mg/kg body weight for 22 weeks. Administration suppressed DMBA-induced...
Cisplatin (CIS) is a broad-spectrum anti-carcinogen that causes cytotoxic effects both in normal and cancer cells. The purpose of this study was to test whether Hibiscus sabdariffa (HS) extract can reduce CIS-induced hepatotoxicity rodents assess its anticancer activity vitro. Treatment with HS at daily doses 500 mg/kg before after single dose CIS (10 mg/kg) reduced Wistar male albino rats. hepatic damage marker enzymes ( i.e. alanine aspartate aminotransferases), necrosis, apoptosis liver...
The current research employed an animal model of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary gland carcinogenesis. estrogen receptor-positive human breast adenocarcinoma cell line (MCF-7) was used for in vitro analysis. This combined with a network pharmacology-based approach to assess the anticancer properties Spirulina (SP) extract and understand its molecular mechanisms. results showed that administration 1 g/kg SP increased antioxidant activity by raising levels catalase (CAT)...
Hydrogen sulfide (H 2 S) is an endogenously gas transmitter signaling molecule with known antioxidant, anti-inflammatory, and cytoprotective properties. Although accumulating evidence shows the therapeutic potential of H S in various hepatic diseases, its role cyclophosphamide (CP)-induced hepatotoxicity remains elusive. The present study was undertaken to investigate impact endogenous exogenous on toll-like receptors (TLRs)-mediated inflammatory response apoptosis CP-induced hepatotoxicity....
Metal nanoparticle synthesis using plant has emerged as an eco-friendly, clean, and viable strategy alternative to chemical physical approaches.The fruit extract of Salvadora persica (SP) was utilized a reducing stabilizing agent in the gold (AuNPs) copper (CuNPs) nanoparticles.UV-Vis spectra AuNPs CuNPs showed peaks at wavelengths 530 nm 440 nm, respectively. Transmission electron microscopy that nanoparticles exhibited mainly spherical form, with distribution range 100 113 diameter for 130...
Abstract Vitamin D supplementation with standard treatment yielded positive clinical outcomes in mild and moderate atopic dermatitis; however, the potential benefit of vitamin severe cases remains unclear. This study aimed to evaluate impact on response pediatrics dermatitis. The patients were randomized receive either 3 1600 IU/day or placebo, plus baseline therapy topical 1% hydrocortisone cream twice daily for 12 weeks. primary endpoints change mean Eczema Area Severity Index (EASI) score...
Abstract Background The therapeutic value of doxorubicin as an effective anti-neoplastic agent is limited by its cardiotoxic side effects. We investigated the effects ethanolic leaf extracts olive OL on cardiotoxicity well oxidative stress which was induced (DOX) in Wistar rats. intraperitoneally injecting a single dose (10 mg kg −1 ) after 7 days administration. given gastric gavage 250 mg/kg, 500 mg/kg and 1000 doses extract for 10 days. Results Cardiac toxicity DOX evidenced...
Introduction: Aluminium (Al) is accumulated in the brain causing neurotoxicity and neurodegenerative disease like Alzheimer's (AD), multiple sclerosis, autism epilepsy. Hence, attenuation of Al-induced has become a "hot topic" looking for an intervention that slow down progression diseases. Objective: Our study aims to introduce new strategy hampering aluminum chloride (AlCl3)-induced using combination sesamol with probiotic bacteria; Lactobacillus rhamnosus (L. rhamnosus) also test their...
Abstract Derivatives of Carya illinoinensis (pecan) are used as dietary supplements and their leaf nuts-in-shuck extracts in the treatment various pathologies due to significant composition phenolic compounds that act natural antifungal anticancer agents. This study aimed evaluate activity acetone (AEs) from leaves (L) nuts-in-shucks (S) cultivars (cv.) Wichita (Wic) Ukulinga (Uku) South African C. against A. alternata pathogen. The AEs Wic-L Uku-L showed higher efficacy all tested isolates,...
Abstract Purpose This study aimed to develop a transdermal delivery system for fluocinolone acetonide (FLA), corticosteroid used in treating inflammatory conditions like rheumatoid arthritis (RA), overcome the limitations of oral administration, such as poor solubility and bioavailability. Methods FLA-loaded PEG decorated hyalurosomes (FLA-PHs) were fabricated using ethanol injection, incorporating various Brij® surfactants different amounts hyaluronic acid (HA) based on full factorial...
Background: Doxorubicin (DOX) is a very powerful chemotherapy drug. However, its severe toxicity and potential for resistance development limit application. Withania somnifera L. Dunal (WIT) has therapeutic capacities, including anti-inflammatory, antioxidant, anticancer activities. This study investigates the preventative benefits of standardized WIT extract against DOX-induced renal damage in vivo. We also investigate synergistic effects combining DOX to improve efficacy breast cancer...
Novel halogenated phenoxychalcones 2a-f and their corresponding N-acetylpyrazolines 3a-f were synthesised evaluated for anticancer activities against breast cancer cell line (MCF-7) normal (MCF-10a), compared with staurosporine. All compounds showed moderate to good cytotoxic activity when control. Compound 2c was the most active, IC50 = 1.52 µM selectivity index 15.24. Also, chalcone 2f significant 1.87 11.03. decreased both total mitogen activated protein kinase (p38α MAPK) phosphorylated...
Abstract Background: Inflammatory polyps in patients with Bowel Disease (IBD) pose a significant risk for colorectal cancer (CRC). Dietary interventions targeting anti-tumor immunity are crucial mitigating this risk. Aim: We investigated saffron's anti-inflammatory effects IBD due to the high prevalence of polyps, aiming prevent CRC. Methods: The study retrospectively evaluated 485 colitis (70 IBD, 415 NIC) from Howard University Hospital, through colonoscopy, pathology, and clinical reports...
This study comprises the design and synthesis of novel nicotinic acid-based cytotoxic agents with selective inhibitory efficacy against vascular endothelial growth factor receptor-2 (VEGFR-2). Screening compounds for cytotoxicity was assessed 60 human cancer cell lines. The two most active compounds, 5b 5c, reference drugs sorafenib doxorubicin were investigated HCT-15, PC-3, CF-295 Compound 5c exhibited highest potential compared to HCT-15 PC-3 tumor Moreover, it higher selectivity toward...
Alzheimer's disease (AD) is the most common cause of dementia where symptoms gradually deteriorate over years. We previously reported that social isolation exacerbates memory loss while mental and physical activities maintain cognitive functions. Epigallocatechin-3-gallate (EGCG), a natural chelator, wheatgrass, antioxidant could provide CNS health-promoting effects. The study aimed to investigate combined effects EGCG wheatgrass together with against AD in socialized isolated conditions....
Background: Several trials have reported that dipeptidyl peptidase-4 (DPP-4) inhibitors are used to improve endothelial function in addition treating type 2 diabetes (T2DM). The current study investigated the effects of vildagliptin, DPP-4 inhibitor, compared metformin on and blood pressure through vascular growth factor (VEGF) modulation patients with T2DM hypertension. Methods: This was designed as a randomized controlled parallel study. A total 120 volunteers were recruited allocated into...