A5013685037- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Impact and Responses
- HIV-related health complications and treatments
- HIV/AIDS oral health manifestations
- Hemoglobinopathies and Related Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Blood donation and transfusion practices
- Sex work and related issues
- Animal Disease Management and Epidemiology
- Hepatitis C virus research
- Adolescent Sexual and Reproductive Health
- Hepatitis B Virus Studies
- T-cell and Retrovirus Studies
- Malaria Research and Control
- Blood groups and transfusion
- Fungal Infections and Studies
- Molecular Biology Techniques and Applications
- Vector-Borne Animal Diseases
- Antifungal resistance and susceptibility
- Oral Health Pathology and Treatment
- Chronic Disease Management Strategies
- Syphilis Diagnosis and Treatment
University of Kinshasa
2015-2025
National Institute of Biomedical Research
2024
Abstract Background The Democratic Republic of Congo (DRC) has one the highest maternal and neonatal mortality rates in Africa. There is a growing body evidence about relationship between poor oral health adverse pregnancy outcomes. However, there lack information status during DRC. This study aimed to identify factors related utilization care services among pregnant women. Methods A hospital-based cross-sectional was conducted four facilities representing each administrative district city...
The Democratic Republic of the Congo adopted integrase inhibitor dolutegravir (DTG) as part its preferred first-line HIV treatment regimen in 2019. This study aimed to identify predictors viral non-suppression among HIV-infected patients under a DTG-based context ongoing armed conflict since 2017 city Bunia DRC. We conducted cohort 468 living with DTG all health facilities Bunia. calculated proportion participants an RNA below 50 copies per milliliter. About three four (72.8%) this had load...
Context: Since the transition to Dolutegravir (DTG) in 2019, several studies have been documented on People Living with HIV (PLHIV) Democratic Republic of Congo (DRC) and particularly Kinshasa.Nevertheless, no study was found socio-demographic anthropometric profile PLHIV who start treatment Kinshasa after 2019.Objective: The objective this is determine Sociodemographic Anthropometric starting AntiRetroViral era.Method: This a descriptive cross-sectional ARV Outpatient Treatment Centers...
The East African Community (EAC) is experiencing an unprecedented, emerging mpox outbreak since July 2024 in five of eight partner states. We highlight rapid regional response measures, initiated August coordinated by EAC: field deployment six mobile laboratories Burundi, Rwanda, Uganda, Tanzania, Kenya, South Sudan to high-risk areas, donation one laboratory Democratic Republic the Congo and genomic monkeypox virus (MPXV) surveillance support. These interventions aim limit local spread...
Background: Viral Load (VL), CD4 T cells count and clinical signs are significant parameters for the decision of starting ARV Treatment (ART).The aim this study is to determine profile eligible patients on treatment in centers according algorithm used Kinshasa DRC.Methodology: Our sample consisted 153 HIV-positive naïve ART.All aged over 18 years were included without gender discrimination.The determination VL was made at laboratory Molecular Biology Faculty Medicine University using a...
This study aimed to examine the incidence and predictors of loss follow up (LTFU) in context ongoing atrocities caused by armed conflict, where HIV treatment programs HIV-infected patients may face unique challenges terms ART adherence retention care. We conducted an observational prospective cohort 468 living with (PLWHIV) under dolutegravir (DTG) all health facilities Bunia between July 2019 2021. Kaplan–Meier plots were used determine probability LTFU as a function time inclusive cohort....
Background: Anemia remains the most frequent hematological complication during HIV/AIDS infection.Objective: The objective of this study was to determine prevalence anemia among People Living with HIV (PLHIV) who start AntiRetroViral treatment in Kinshasa era Dolutegravir.Methods: This a descriptive cross-sectional PLHIV at ARV Treatment (ART) 13 Outpatient Centers (OTC) Kinshasa.The patient inclusion period from October 04, 2021 February 15, 2022.Patients included present were type 1...
Background: Measurement of Viral Load (VL) is the most reliable mean for evaluating virological monitoring Human Immunodeficiency Virus (HIV) infection.It allows determination amount virus present in a given volume.Due to constraints costs, VL not often requested patient's follow-up countries with limited resources.Hence objective this study implement an in-house Quantitative Real-Time PCR assess HIV infected patients Kinshasa.Methods: One hundred and fifty five positive type 1, naive...
The national antiretroviral therapy in the Republic of Chad provides free charge regimens and therapeutic monitoring for patients receiving nationwide. For a successful programmatic uptake, these efforts merit to be supported by thorough assessments response HIV-1 drug resistance surveillance, especially with risks cross-resistance due gradual stavudine phasing out such settings. We therefore evaluated virological therapy, emergence circulating clades context. A cross-sectional prospective...
Background: The massive use of antiretroviral (ARV) created the emergence mutant strains resistant to treatment. Thus, World Health Organization (WHO) recommends epidemiological monitoring for newly infected patients with Human Immunodeficiency Virus (HIV). objective this study is determine genetic diversity HIV Type 1 and prevalence mutations associated resistance ARV in treatment-naive Kinshasa. Methods: One hundred fifty-three subjects diagnosed positive voluntarily participated study....
This study aims to determine the factors influencing HIV-related mortality in settings experiencing continuous armed conflict atrocities. In such settings, people living with HIV (PLHIV), and partners of those affected may encounter specific difficulties regarding adherence antiretroviral therapy (ART), retention prevention, treatment, care programs. Between July 2019 2021, we conducted an observational prospective cohort 468 PLHIV patients treated Dolutegravir at all ART facilities Bunia....
Context: For several decades, the introduction of AntiRetroViral (ARV) has allowed an improvement in clinical signs patients, a spectacular reduction mortality and morbidity, extension life quality many People Living with HIV (PLHIV).Objective: The objective this study was to determine profile PLHIV starting ARV Treatment Kinshasa era Dolutegravir.Methods: This is descriptive cross-sectional treatment Outpatient Centers (OTC) Kinshasa.Thirteen OTC across city had been included because their...
Context: The retention of People Living with HIV (PLHIV) and on Antiretroviral (ARV) in Outpatient Treatment Centers (OTC) remains a major challenge Africa, particularly cross-border areas due to the high mobility population.Objective: objective this study was determine reasons behind loss patients (ART) after 6 months follow-up.Methods: This is descriptive survey present for PLHIV at th month ART OTC Kinshasa.The population HIV-infected adults over age 18 first-line OTCs included study.The...
Background: For several decades, the introduction of AntiRetrovirals (ARVs) has improved symptomatology People Living with HIV (PLHIV), a spectacular reduction in morbidity and mortality, an improvement life expectancy quality PLHIV. Objective: The objective this study was to determine profile PLHIV initiating AntiRetroViral Treatment (ART) era Dolutegravir Kinshasa. Methods: Cross-section prospective cohort ART inclusions were from October 04, 2021 February 15, 2022. Confirmation diagnosis...
Context: Despite the new recommendations “Test and Treat”, virological molecular parameters remain important information for Antiretroviral Treatment adequate monitoring of patients infected with HIV/AIDS. Objective: Objective this study is to present profile People Living HIV starting Therapy in Kinshasa era Dolutegravir. Methods: This was a transversal determine (PLHIV) an ARV Treatment. The patient’s inclusion period from October 04, 2021 February 15, 2022. A sample 5 ml blood taken tube...
Context: In the Democratic Republic of Congo (DRC), Antiretroviral (ART) drug coverage is still very low throughout country.Hence, a large number People Living with HIV (PLHIV) use traditional treatment made from plants to fight infection and opportunistic associated it.Objective: The objective this work was evaluate clinical parameters; para socio-demographic studies at beginning who adhere in Kinshasa.Methods: A cohort study conducted Bonkoko center baseline 3 months; 97 positive patients...
Context: The in-house techniques or experimental methods are increasingly recommended for their low-cost reagents the determination of Viral Load (VL) in resource-limited settings.The objective this study was to compare VL from HIV-1 non-B samples by an technique with COBAS AmpliPrep/TaqMan version 2.0.Method: In cross-sectional study, 39 plasma patients infected HIV type 1 N'Djamena and Kinshasa were used determine using two techniques.Results: mean values respectively 4.68 ± 1.26 4.58 1.33...
Background: Infection with the Human Immunodeficiency Virus (HIV) and malaria are two infectious diseases which among leading causes of morbidity mortality in Sub-Saharan Africa each a major public health problem.Data on infection people living HIV (PLHIV) poorly defined Kinshasa as there very few studies available subject.Objective: To determine rate co-infection HIV/malaria to improve care PLHIV, this study was initiated update data.Methodology: This prospective cohort.123 volunteers...
Background: The prevalence of Human Immunodeficiency Virus (HIV) infection was 1.2% in the Democratic Republic Congo, according to Demographic Health Study report 2014.In 2012, severe failure rate first-line ART Kinshasa estimated at more than 16%.Objective: objective this study is determine clinical, immunological and virological treatment Kinshasa.Methodology: At 6th month Antiretroviral Treatment (ART), 138 patients from a follow-up cohort 8 centers were received for paraclinical...
Context: For the year 2018, Provincial Division of National Program for Fight against HIV/AIDS and Sexually Transmitted Diseases published city Kinshasa a total 58,327 People Living with HIV (PLHIV) on Antiretroviral Treatment (ART) which 5789 (9.9%) were second-line ART.Objective: The objective this study was to determine clinical paraclinical profile people living treatment followed in Kinshasa.Methods: present an exploratory cohort evaluate PLHIV Kinshasa.All confirmed first-line failure...
Neuromeningeal cryptococcosis (NMC) is one of the most frequent opportunistic infections (OI) in Human Immunodeficiency Virus (HIV) infection. In Kinshasa, latest data on were published 1996. The objective was to describe epidemiological, clinical and biological profiles NMC HIV-infected people living Kinshasa. This a descriptive study based medical records patients who attended three clinics Kinshasa between January 1st 2011 December 31st 2014. Only presenting reviewed. During 4 year-period...
Context: The biochemical assessment is a real-time indicator of the state and evolution an infection.Among other things, it makes possible to determine right moment when becomes necessary start or change treatment.Objective: objective this study present Biological profile People Living with HIV starting AntiRetroViral treatment in Kinshasa era Dolutegravir.Methods: descriptive crosssectional biological (PLHIV) Treatment (ART).The patient inclusion period was from October 4, 2021 February 15,...