A5044294251- Asymmetric Hydrogenation and Catalysis
- Thermochemical Biomass Conversion Processes
- Carbon dioxide utilization in catalysis
- Lignin and Wood Chemistry
- Nanomaterials for catalytic reactions
- Chemical Synthesis and Analysis
- Catalytic Cross-Coupling Reactions
- Catalysis and Hydrodesulfurization Studies
- Catalytic C–H Functionalization Methods
- Catalysis for Biomass Conversion
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Cannabis and Cannabinoid Research
- Energetic Materials and Combustion
- Organoboron and organosilicon chemistry
- Lubricants and Their Additives
- Hydrogen Storage and Materials
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Biochemical and biochemical processes
- Neuropeptides and Animal Physiology
- Biofuel production and bioconversion
- Tribology and Wear Analysis
- Adsorption and biosorption for pollutant removal
- Natural Fiber Reinforced Composites
- Pharmacological Receptor Mechanisms and Effects
Guangdong Pharmaceutical University
2020-2024
Zhejiang A & F University
2020-2024
Hunan University
2024
Sun Yat-sen University
2018-2022
China Pharmaceutical University
2014-2020
Chinese Academy of Engineering
2020
State Key Laboratory of Natural Medicine
2020
State Council of the People's Republic of China
2015
Amgen (United States)
2007-2008
Array BioPharma (United States)
2007
The first example of room temperature non-noble metal homogeneous system catalyzed selective N-alkylation anilines with alcohols by a bis-NHC manganese complex is presented. This was applied to large range and anilines, including biologically relevant motifs challenging methanol. Experimental computational studies suggest an outer-sphere mechanism for this NHC-Mn system.
The unusual nonbifunctional outer-sphere strategy was successfully utilized in developing an easily accessible N-heterocyclic carbene manganese (NHC-Mn) system for highly active α-alkylation of ketones with alcohols. This efficient a wide range and alcohols under mild reaction conditions, also the green synthesis quinoline derivatives. direct mechanism high activity present demonstrate potential catalyst design acceptorless dehydrogenative transformations.
A bifunctional strategy for efficient Ir-catalyzed <italic>N</italic>-alkylation of amines and sulfonamides with alcohols under aqueous base-free conditions.
Abstract Biochar is a potential porous carbon to remove the contaminants from aquatic environments. Herein, N-doped hierarchical biochar was produced by combined approach of ammonia torrefaction pretreatment (ATP) and alkali activation. ATP could not only incorporate N element into poplar wood, but obtain loose structure wood. The highest surface area 2324.61 m 2 g −1 after wet pretreatment, which higher than that activation (1401.82 ) without (2111.03 atmosphere. presented adsorption...
Abstract A sustainable and green route to access diverse functionalized ketones via dehydrogenative–dehydrative cross‐coupling of primary secondary alcohols is demonstrated. This borrowing hydrogen approach employing a pincer N‐heterocyclic carbene Mn complex displays high activity selectivity. variety are well tolerant result in satisfactory isolated yields. Mechanistic studies suggest that this reaction proceeds direct outer‐sphere mechanism the dehydrogenation alcohol substrates plays...
An example of homogeneous Mo-catalyzed direct N-alkylation anilines or nitroarenes with alcohols is presented. The DFT aimed design suggested the easily accessible bis-NHC-Mo(0) complex features a strong hydride-donating ability, achieving effective challenging alcohols. enhanced strategy should be useful in designing highly active systems for borrowing hydrogen transformations.
A Ru catalyst with the hetero-bidentate NHC-phosphine ligand, which realizes <italic>N</italic>-alkylation of amines alcohols improved catalytic activity.
Good permeability to cross the blood–brain barrier; low toxicity PC12 cells.
Abstract The implementation of non‐noble metals mediated chemistry is a major goal in homogeneous catalysis. Borrowing hydrogen/hydrogen autotransfer (BH/HA) reaction, as straightforward and sustainable synthetic method, has attracted considerable attention the development metal catalysts. Herein, we report tungsten‐catalyzed N ‐alkylation reaction anilines with primary alcohols via BH/HA. This phosphine‐free W(phen)(CO) 4 (phen=1,10‐phenthroline) system was demonstrated practical easily...
Abstract Cross‐coupling of nitriles and alcohols offers an environmentally friendly atom‐economical method for the synthesis various valuable compounds. These compounds include α ‐alkylated ‐olefinated nitriles, primary amines, imines, N ‐alkylation amides, ‐heterocycles, δ ‐hydroxynitriles, olefins, etc . Herein, we have reviewed recent developments (from 2013–date) transition‐metal‐catalyzed cross‐coupling alcohols. A number transition metal complexes such as noble metals Ru Ir, well base...
The CB2 receptor is an attractive therapeutic target for analgesic and anti-inflammatory agents. Herein we describe the discovery of a novel class oxadiazole derivatives from which potent selective agonist leads were developed. Initial hit 7 was identified cannabinoid target-biased library generated by virtual screening sample collections using pharmacophore model in combination with series physicochemical filters. demonstrated to be (CB2 EC50 = 93 nM, Emax 98%, CB1 > 10 μM). However, this...