About
Contact & Profiles
A5101595470
Research Areas
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal Development and Disorders
- Retinal Diseases and Treatments
Photoreceptor degeneration is a cause of irreversible vision loss in incurable blinding retinal diseases including retinitis pigmentosa (RP) and atrophic age-related macular degeneration. We found two separate mouse models photoreceptor that tamoxifen, selective estrogen receptor modulator drug previously linked with toxicity, paradoxically provided potent neuroprotective effects. In light-induced model, tamoxifen prevented onset apoptosis atrophy maintained near-normal levels...
10.1523/jneurosci.2717-16.2017
article
EN
cc-by-nc-sa
Journal of Neuroscience
2017-02-24
Coming Soon ...