A5031458112- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Photochemistry and Electron Transfer Studies
- Advanced Nanomaterials in Catalysis
- Supramolecular Self-Assembly in Materials
- Energetic Materials and Combustion
- Organic Light-Emitting Diodes Research
- Optical Imaging and Spectroscopy Techniques
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Respiratory viral infections research
- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
- SARS-CoV-2 detection and testing
- Photoacoustic and Ultrasonic Imaging
- Chemical Thermodynamics and Molecular Structure
- Polydiacetylene-based materials and applications
- Lanthanide and Transition Metal Complexes
- Synthesis and Reactivity of Heterocycles
- Chemical Reactions and Mechanisms
- Luminescence and Fluorescent Materials
University of California, San Diego
2022-2023
University of Florida
2015
Surface ligands play a critical role in controlling and defining the properties of colloidal nanocrystals. These aspects have been exploited to design nanoparticle aggregation-based colorimetric sensors. Here, we coated 13-nm gold nanoparticles (AuNPs) with large library (e.g., from labile monodentate monomers multicoordinating macromolecules) evaluated their aggregation propensity presence three peptides containing charged, thiolate, or aromatic amino acids. Our results show that AuNPs...
Plasmonic coupling via nanoparticle assembly is a popular signal-generation method in bioanalytical sensors. Here, we customized an all-peptide-based ligand that carries anchoring group, polyproline spacer, biomolecular recognition, and zwitterionic domains for functionalizing gold nanoparticles (AuNPs) as colorimetric enzyme sensor. Our results underscore the importance of module, which enables SARS-CoV-2 main protease (Mpro) to recognize peptidic on nanosurfaces subsequent plasmonic...
Abstract 3D‐bioprinted skin‐mimicking phantoms with skin colors ranging across the Fitzpatrick scale are reported. These tools can help understand impact of phototypes on biomedical optics. Synthetic melanin nanoparticles different sizes (70–500 nm) and clusters fabricated to mimic optical behavior melanosome. The absorption coefficient reduced scattering comparable real human skin. Further content distribution in versus skins validated via photoacoustic (PA) imaging. PA signal phantom be...
There is a need for surveillance of COVID-19 to identify individuals infected with SARS-CoV-2 coronavirus. Although specific, nucleic acid testing has limitations in terms point-of-care testing. One potential alternative the nonstructural protease (nsp5, also known as Mpro/3CLpro) implicated viral replication but not incorporated into virions. Here, we report divalent substrate novel design, (Cys)2–(AA)x–(Asp)3, interface gold colloids specific presence Mpro leading rapid and colorimetric...
Electrostatic interactions are a key driving force that mediates colloidal assembly.
Better insights into the fate of membraneless organelles could strengthen understanding transition from prebiotic components to multicellular organisms. Compartmentalized enzyme reactions in a synthetic coacervate have been investigated, yet there remains gap interactions with as substrate hub. Here, we study how molecularly crowded nature affects embedded protease. We design oligopeptide-based coacervates that comprise an anionic Asp-peptide (D10) and cationic Arg-peptide (R5R5) proteolytic...
Aromatic interactions are commonly involved in the assembly of naturally occurring building blocks, and these can be replicated an artificial setting to produce functional materials. Here we describe a colorimetric biosensor using co-assembly experiments with plasmonic gold surfactant-like peptides (SLPs) spanning wide range aromatic residues, polar stretches, interfacial affinities. The SLPs programmed DDD-(ZZ)
Abstract An efficient cyclization between nitro‐substituted benzoic acids and benzohydrazides affords 1,3,4‐oxadiazoles. Facile synthesis a broad substrate scope produce range of compounds, some them with potential as high‐energy compounds. Heats formation (Δ H f ) densities ( ρ were calculated, heats decomposition d combustion c determined experimentally. The seven the synthesized compounds by gas pycnometry, respective values detonation velocity V D ), pressure P specific impulse I SP...
Noroviruses are highly contagious and one of the leading causes acute gastroenteritis worldwide. Due to a lack effective antiviral therapies, there is need diagnose surveil norovirus infections implement quarantine protocols prevent large outbreaks. Currently, gold standard diagnosis uses reverse transcription polymerase chain reaction (RT-PCR), but PCR can have limited availability. Here, we propose combination tunable peptide substrate nanoparticles (AuNPs) colorimetrically detect...
We report here a colorimetric method for rapid detection of norovirus based on the valence-driven peptide-AuNP interactions. engineered peptide sequence named K1 with cleavage in between two lysine residues. The positively charged groups aggregated negatively nanoparticles leading to purple color change. There was red when digested by Southampton 3C-like protease (SV3CP)-a involved life cycle Human (HNV). limit determined be 320 nM Tris buffer. further show that sensor has good performance...
Abstract Aromatic interactions are commonly involved in the assembly of naturally occurring building blocks, and these can be replicated an artificial setting to produce functional materials. Here we describe a colorimetric biosensor using co‐assembly experiments with plasmonic gold surfactant‐like peptides (SLPs) spanning wide range aromatic residues, polar stretches, interfacial affinities. The SLPs programmed DDD−(ZZ) x −FFPC self‐assemble into higher‐order structures response protease...
Transition metal complexes are utilized in a broad array of applications such as photoredox catalysis, photodynamic therapy, biological sensing, and phosphors for organic light-emitting diodes. Furthermore, many transition metals demonstrate two photon absorption reverse saturable (RSA) characteristics increasing their non-linear optical materials. Iridium is particular interest to our work because its strong spin-orbit coupling, which allows multiple excited states, thereby the compound's...
Syntheses of nitrogen rich, energetic N-(nitro-substituted-benzoylimino)pyridinium and N-(nitro- substituted-benzoylimino)1,2,4-triazolium imides are reported their properties calculated/determined in terms heats formation (HOF), densities, detonation parameters, decomposition combustion.
Cyclometalated iridium complexes are a specific class of transition metal chromophores (TMCs) widely employed as phosphors in organic light emitting diodes (OLEDs), photoredox catalysts, and increasingly non-linear optical (NLO) materials. This research investigated the effect derivatization on parent complex [Ir(pbt)2(acac)], where pbt is 2-phenylbenzothiazole acac acetylacetonate. Specifically, hole transport groups, either triphenylamines or carbazoles, were installed at different...