A5006109980- Leprosy Research and Treatment
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
- Immune responses and vaccinations
- Viral Infections and Outbreaks Research
- Immunodeficiency and Autoimmune Disorders
- Viral Infections and Vectors
- Vaccine Coverage and Hesitancy
- Mosquito-borne diseases and control
- COVID-19 and Mental Health
- Milk Quality and Mastitis in Dairy Cows
- SARS-CoV-2 and COVID-19 Research
Animal Resources Development Department
2019
Abstract Background Leprosy is an infectious disease with a slow decline in global annual caseload the past two decades. Active case finding and post-exposure prophylaxis (PEP) single dose of rifampicin (SDR) are recommended by World Health Organization as measures for leprosy elimination. However, more potent PEP regimens needed to increase effect groups highest at risk (i.e., household members blood relatives, especially multibacillary patients). The PEP++ trial will assess effectiveness...
Transmission of Mycobacterium leprae, the pathogen causing leprosy, is still persistent. To facilitate timely (prophylactic) treatment and reduce transmission it vital to both early diagnose identify infected individuals lacking clinical symptoms. However, leprosy-specific biomarkers are limited, particularly for paucibacillary disease. Therefore, our objective was new leprosy assess their applicability in point-of-care (POC) tests.Using multiplex-bead-arrays, 60 host-proteins were measured...
Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is often late- or misdiagnosed leading to irreversible disabilities. Blood transcriptomic biomarkers that prospectively predict those who progress leprosy (progressors) would allow early diagnosis, better treatment outcomes and facilitate interventions aimed at stopping bacterial transmission. To identify potential risk signatures of leprosy, we collected whole blood household contacts (HC, n=5,352) patients, including...
To end the decade-long, obstinately stagnant number of new leprosy cases, there is an urgent need for field-applicable diagnostic tools that detect infection with Mycobacterium leprae, leprosy's etiologic agent. Since immunity against M. leprae characterized by humoral and cellular markers, we developed a lateral flow test measuring multiple host proteins based on six previously identified biomarkers various phenotypes. This multi-biomarker (MBT) demonstrated feasibility quantitative...
Leprosy is a chronic infectious disease, caused by Mycobacterium leprae, that can lead to severe life-long disabilities. The transmission of M. leprae continuously ongoing as witnessed the stable new case detection rate. majority exposed individuals does, however, not develop leprosy and protected from infection innate immune mechanisms. In this study relation between markers well occurrence was studied in household contacts (HCs) patients with high bacillary loads. Serum proteins associated...
Abstract Background Detection of infection with Mycobacterium leprae allows timely prophylactic treatment, thereby reducing transmission as well the risk permanent, leprosy-associated nerve damage. However, since there is no worldwide-implemented standard test for M. infection, detection in asymptomatic individuals remains a major challenge control programs endemic areas. In previous studies, we developed and field-tested lateral flow assay (LFA) quantitatively detecting human IgM against...
Leprosy is an infectious disease caused by Mycobacterium leprae leading to irreversible disabilities along with social exclusion. a spectral for which the clinical outcome after M. infection determined host factors. The spectrum spans from anti-inflammatory T helper-2 (Th2) immunity concomitant large numbers of bacteria as well antibodies against antigens in multibacillary (MB) leprosy, paucibacillary (PB) leprosy characterised strong pro-inflammatory, Th1 Th17 immunity. Despite decades...
Abstract Background Leprosy is an infectious disease with a slow decline in global annual caseload the past two decades. Active case finding and post-exposure prophylaxis (PEP) single dose of rifampicin (SDR) are recommended by World Health Organization as measures for leprosy elimination. However, more potent PEP regimens needed to increase effect groups highest at risk (i.e., household members blood relatives, especially multibacillary patients). The + trial will assess effectiveness...
The present study was designed to correlate the aspartate transaminase (AST), alanine (ALT) and acid phosphatase activities in buffalo milk related udder health status.A total of 60 buffaloes were randomly selected irrespective their age , breed, feeding practice, stage season lactation from herd belonging Purnadhadi unit, PGIVAS; Teaching Veterinary Clinical complex, Polyclinic, Akola also farmers around Akola.After thorough clinical examination each about 30 mL collected sterilized, clean,...