A5102825220- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antibiotic Resistance in Bacteria
- Pharmacological Effects of Natural Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Vitamin K Research Studies
- Maternal and Neonatal Healthcare
- Brain Metastases and Treatment
- Neonatal Respiratory Health Research
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 and Mental Health
- Pediatric health and respiratory diseases
- Cancer therapeutics and mechanisms
- Phytochemicals and Medicinal Plants
- Respiratory viral infections research
- Child Nutrition and Water Access
- COVID-19 Clinical Research Studies
- Research on Leishmaniasis Studies
- Neonatal skin health care
- Radiomics and Machine Learning in Medical Imaging
- Global Maternal and Child Health
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical Practices and Patient Outcomes
- Natural Antidiabetic Agents Studies
- Drug-Induced Adverse Reactions
Government Royapettah Hospital
2024-2025
aTyr Pharma (United States)
2023
Tata Memorial Hospital
2017
All India Institute of Medical Sciences
2016
Sri Ramachandra Institute of Higher Education and Research
2011
Background: Preliminary evidence for efficacy in pulmonary sarcoidosis has been shown efzofitimod. Here we present supportive of based on an exposure-response analysis. Methods: Data from two studies (Phase 1, N = 24, single dose healthy volunteers, and Phase 1b/2a, 25, multiple doses over 24 weeks participants with sarcoidosis) were used to build a population pharmacokinetic model. Using this model, the relationship between efzofitimod exposure three prespecified parameters [mean daily oral...
In a phase 1b/2a clinical trial of efzofitimod in patients with corticosteroid-requiring pulmonary sarcoidosis, treatment resulted dose-dependent improvement key end-points. We undertook post hoc analysis pooling dose arms that achieved therapeutic concentrations (Therapeutic group) versus those did not (Subtherapeutic group). Peripheral blood mononuclear cells incubated tuberculin-coated beads were exposed to varying an vitro assay determine inhibited granuloma formation. the analysis, we...
Temozolomide (TMZ) is an integral part of upfront treatment high-grade gliomas. It administered postsurgery as concurrent therapy with radiation and subsequently adjuvant chemotherapy for 6-12 cycles. unknown whether rechallenge salvage TMZ in previously treated glioma has any efficacy.Patients rechallenged between January 2015 August 2016 were included this retrospective analysis. SPSS version 20 was used Time to event analysis performed using the Kaplan-Meier method. Progression-free...
<b>Introduction:</b> Efzofitimod was evaluated in an ascending dose study (3 cohorts - 1, 3, 5 mg/kg; 6 monthly doses) patients with chronic pulmonary sarcoidosis (prednisone equivalent ≥10 mg/day). Patients were randomized 1:2 (placebo:efzofitimod). Dose dependent improvements steroid burden, FVC and patient reported outcomes (PROs) noted [1]. We pooled data to gain precision investigate novel definitions of responder analyses. <b>Methods:</b> The placebo (n=12) 1 mg/kg arm (n=8)...
Fazit Für die routinemäßige Applikation von intramuskulärem Vitamin K zur Reduktion später VKDB gibt es nur relativ wenig Evidenz aus Beobachtungsstudien. Angesichts der Häufigkeit und hohen Morbidität Mortalität halten Autoren eine generelle postpartale Vitamin-K-Prophylaxe für alle Neugeborenen trotzdem gerechtfertigt. In zukünftigen Studien sollte Effektivität Sicherheit mehrfacher oraler Dosen im Vergleich intramuskulären Prophylaxe untersucht werden optimale Dosis bei Frühgeborenen...
The prevalence of diabetes mellitus is progressively on the rise in India. It considered as equivalent to cardio vascular and cerebro disease[1]. Treatment with allopathic medicine though effective poses high economic burden individual well-known side effects which reduces compliance[2]. There constant search for drugs from alternative medicine[3]. PURSE HIS (Prevalence risk factors detection occult overt endovascular disease Urban, Rural SEmiurban regions Holistic Intervention Study) cohort...