A5074264290- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Tuberculosis Research and Epidemiology
- CAR-T cell therapy research
- Cytomegalovirus and herpesvirus research
- Diagnosis and treatment of tuberculosis
- Mycobacterium research and diagnosis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Bacterial Infections and Vaccines
- Cancer therapeutics and mechanisms
- Immune Cell Function and Interaction
Broad Institute
2017
Allen Institute
2015
IIT@MIT
2015
Massachusetts General Hospital
2014
Massachusetts Institute of Technology
2011
Nanoparticle-functionalized T cells actively transport a cytotoxic drug to systemic sites of lymphoma dissemination, enhancing the efficacy antitumor chemotherapy.
Mycobacterium tuberculosis remains a significant threat to global health. Macrophages are the host cell for M. infection, and although bacteria able replicate intracellularly under certain conditions, it is also clear that macrophages capable of killing if appropriately activated. The outcome infection determined at least in part by host-pathogen interaction within macrophage; however, we lack complete understanding which pathways critical bacterial survival replication. To add our molecular...
A key to the pathogenic success of Mycobacterium tuberculosis (Mtb), causative agent tuberculosis, is capacity survive within host macrophages. Although several factors required for this survival have been identified, a comprehensive knowledge such and how they work together manipulate environment benefit bacterial are not well understood. To systematically identify Mtb intracellular growth, we screened an arrayed, non-redundant transposon mutant library by high-content imaging characterize...