A5102761875- Neurological Disease Mechanisms and Treatments
- RNA Research and Splicing
- Genetics and Neurodevelopmental Disorders
- Trace Elements in Health
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Heavy Metal Exposure and Toxicity
- Neurogenetic and Muscular Disorders Research
- Migraine and Headache Studies
- Advanced biosensing and bioanalysis techniques
- Genomics and Rare Diseases
- Saffron Plant Research Studies
- RNA and protein synthesis mechanisms
- Viral Infections and Outbreaks Research
- Higher Education Learning Practices
- SARS-CoV-2 and COVID-19 Research
- Neurological diseases and metabolism
- Nuclear Structure and Function
- Laser Applications in Dentistry and Medicine
- Biochemical effects in animals
- Advanced Nanomaterials in Catalysis
- Genetic Neurodegenerative Diseases
- Phytochemistry and Biological Activities
- Medicinal Plants and Bioactive Compounds
Anhui University of Traditional Chinese Medicine
2019-2024
Ministry of Education of the People's Republic of China
2022-2024
University of Calgary
1978
University of British Columbia
1978
Patients infected with the Omicron variant of SARS-CoV-2 mainly develop mild COVID-19, manifesting as upper respiratory symptoms, fatigue, and fever. Shufeng Jiedu capsule (SFJDC), a traditional Chinese medicine indicated for treatment infections in China, was tested its efficacy safety an infection at mobile cabin hospital response to outbreak COVID-19 Shanghai, China April 2022. In this open-label, randomized controlled trial, patients control group received best supportive care, while...
Background: N4-acetylcytidine (ac4C), an important posttranscriptional modification, is involved in various disease processes. Long noncoding RNAs (lncRNAs) regulate gene expression mainly through epigenetic transcription, and modification. Alzheimer’s (AD) a neurodegenerative characterized by amyloidosis of the brain. However, role lncRNA ac4C modification AD remains unclear. Objective: In this study, we investigated association between AD, underlying mechanisms AD. Methods: The male...
ObjectiveTo develop and test a post competency scale for traditional Chinese medicine (TCM) physicians undergoing standardized training to provide an applicable tool scientific evaluation.MethodsBased on literature analysis, behavioral event interviews, expert consultations, measurement questions were formulated the initial was designed. A questionnaire survey conducted from July 2022 May 2023 among TCM in China. The rationality of confirmed through item purification, factor tests...
Autosomal recessive cerebellar ataxia type 1 (ARCA-1), also known as autosomal spinocerebellar 8 (SCAR8), is caused by spectrin repeat containing nuclear envelope protein (SYNE1) gene mutation. Nesprin-1, encoded SYNE1, widely expressed in various tissues, especially the striated muscle and cerebellum. The destruction of Nesprin-1 related to neuronal neuromuscular lesions. It has been reported that SYNE1 variation associated with Emery-Dreifuss muscular dystrophy 4, arthrogryposis multiplex...
Studies show that non-coding RNAs, especially microRNAs (miRNAs) and circular RNAs (circRNAs), protein-coding genes are involved in the pathophysiology of multi-organ damage caused by Wilson’s disease (WD). However, circRNA expression profiles their role initiation progression WD kidney injury remain largely unclear at present. Here, we explored potential critical genes, miRNAs, circRNAs, as well identify competitive endogenous (ceRNAs) a mouse model high-throughput sequencing. We...
Arboleda-Tham syndrome (ARTHS) is a rare disorder first characterized in 2015 and caused by mutations lysine (K) acetyltransferase 6A (KAT6A, a.k.a. MOZ, MYST3). Its clinical symptoms have rarely been reported newborns from birth up to the few months after birth. In this study, newborn was diagnosed with ARTHS based on mutation c.3937G>A (p.Asp1313Asn) KAT6A. The manifestations, diagnosis, treatment of were recorded during follow-up observations. main proband at asphyxia, involuntary...
Background: Mitochondrial membrane protein-associated neurodegeneration (MPAN) mostly arises as an autosomal recessive disease and is caused by variants in the chromosome 19 open reading frame 12 (C19orf12) gene. However, a few C19orf12 monoallelic truncating de novo have been reported segregated dominant traits some cases. Methods: We performed whole-exome sequencing analyzed genes related to associated with brain iron accumulation for pathogenic variants. The identified were confirmed...
Low serum ceruloplasmin concentration is considered robust marker for Wilson disease (WD) screening, measuring oxidase activity might be an even more valuable diagnostic tool, but it has not been sufficiently studied.
To observe the effects of electroacupuncture(EA) at "Fengchi"(GB20) on ethology, microglia activation and P2X7 receptor(P2X7R) expression in periaqueductal gray(PAG) recurrent migraine rat model, so as to explore underlying mechanism EA reducing central sensitization migraine.Thirty-six male SD rats were randomly divided into control, model groups, with 12 each group. Recurrent was induced using repea-ted dural electrical stimulation once another day(the 1st, 3rd, 5th, 7th 9th days), for a...
N4-acetylcytidine (ac4C), a significant modified nucleoside, participates in the development of many diseases. Messenger RNAs (mRNAs) contain most information genome and is molecule that transmits from genes to proteins. Alzheimer's disease (AD) progressive neurodegenerative which fibrillar amyloid plaques are present. However, it remains unknown how mRNA ac4C modification affects AD. In current study, ac4C-modified mRNAs were comprehensively analyzed AD mice by ac4C-RIP-seq RNA-seq. Next,...
Objective. This study aimed to determine the active components of Zhinao capsule (ZNC) and targets in treating Alzheimer’s disease (AD) so as investigate explore mechanism ZNC for AD. Methods. The were determined from traditional Chinese medicine systems pharmacology database (TCMSP). target genes AD searched GeneCards. Cytoscape was used construct an herb-component-target-disease network. A protein-protein interaction (PPI) network constructed by STRING. Gene ontology (GO) Kyoto...
<b><i>Objective:</i></b> The aim of this study was to identify the genetic cause two cases Kufs disease in same family. affected individuals exhibited different levels severity under magnetic resonance imaging (MRI). <b><i>Methods:</i></b> Whole-exome sequencing performed on individuals, and candidate gene confirmed by Sanger sequencing. Western blot analysis used evaluate level expression CLN6 protein 239T cells....