A5009535998- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Photosynthetic Processes and Mechanisms
- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
University of Pittsburgh
2021-2024
Abstract The vast majority of membrane phospholipids (PLs) include two asymmetrically positioned fatty acyls: oxidizable polyunsaturated acids (PUFA) attached predominantly at the sn2 position, and non‐oxidizable saturated/monounsaturated (SFA/MUFA) localized sn1 position. peroxidation PUFA‐PLs, particularly sn2‐arachidonoyl(AA)‐ sn2‐adrenoyl(AdA)‐containing phosphatidylethanolamines (PE), has been associated with execution ferroptosis, a program regulated cell death. There is minor...
Ferroptosis is a redox-driven type of regulated cell death program arising from maladaptation three metabolic pathways: glutathione homeostasis, iron handling and lipid peroxidation. Though GSH/Gpx4 the predominant system detoxifying phospholipid hydroperoxides (PLOOH) in mammalian cells, recently Gpx4-independent regulators ferroptosis like suppressor protein 1 (FSP1) resistant cancer lines iNOS/NO• M1 macrophages have been discovered. We previously reported that Pseudomonas aeruginosa (PA)...
Total body irradiation (TBI) targets sensitive bone marrow hematopoietic cells and gut epithelial cells, causing their death inducing a state of immunodeficiency combined with intestinal dysbiosis nonproductive immune responses. We found enhanced Pseudomonas aeruginosa (PAO1) colonization the leading to host cell strikingly decreased survival irradiated mice. The PAO1-driven pathogenic mechanism includes theft-ferroptosis realized via (a) curbing antiferroptotic system, GSH/GPx4, (b)...
Programmed ferroptotic death eliminates cells in all major organs and tissues with imbalanced redox metabolism due to overwhelming iron-catalyzed lipid peroxidation under insufficient control by thiols (Glutathione (GSH)). Ferroptosis has been associated the pathogenesis of chronic degenerative diseases acute injuries brain, cardiovascular system, liver, kidneys, other organs, its manipulation offers a promising new strategy for anticancer therapy. This explains high interest designing...
Abstract The vast majority of membrane phospholipids (PLs) include two asymmetrically positioned fatty acyls: oxidizable polyunsaturated acids (PUFA) attached predominantly at the sn2 position, and non‐oxidizable saturated/monounsaturated (SFA/MUFA) localized sn1 position. peroxidation PUFA‐PLs, particularly sn2‐arachidonoyl(AA)‐ sn2‐adrenoyl(AdA)‐containing phosphatidylethanolamines (PE), has been associated with execution ferroptosis, a program regulated cell death. There is minor...