A5004503239- Ultrasound and Hyperthermia Applications
- Advanced MRI Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasound Imaging and Elastography
- Uterine Myomas and Treatments
- Cardiovascular Function and Risk Factors
- MRI in cancer diagnosis
- Elasticity and Material Modeling
- Cardiac Imaging and Diagnostics
- Nanoparticle-Based Drug Delivery
- Advanced Neuroimaging Techniques and Applications
- Endometriosis Research and Treatment
- Ultrasound and Cavitation Phenomena
- Microfluidic and Bio-sensing Technologies
- Intestinal and Peritoneal Adhesions
- Cerebrovascular and genetic disorders
- Apelin-related biomedical research
- Kruppel-like factors research
- NMR spectroscopy and applications
- Thermal Regulation in Medicine
- Protein Kinase Regulation and GTPase Signaling
- Prostate Cancer Diagnosis and Treatment
- Numerical methods in inverse problems
- Cardiomyopathy and Myosin Studies
- Congenital heart defects research
Philips (Netherlands)
2011-2023
University Hospital Cologne
2017-2022
University of Cologne
2019-2022
Philips (Germany)
2017-2020
Eindhoven University of Technology
2004-2017
Philips (Finland)
2013
NXP (Netherlands)
2012
Maastricht University
2008
WinnMed
2008
Combining Positron Emission Tomography (PET) with Magnetic Resonance Imaging (MRI) results in a promising hybrid molecular imaging modality as it unifies the high sensitivity of PET for and cellular processes functional anatomical information from MRI. Digital Silicon Photomultipliers (dSiPMs) are digital evolution scintillation light detector technology promise SNR. DSiPMs Philips Photon Counting (PDPC) were used to develop preclinical PET/RF gantry 1-mm crystal pitch an insert clinical MRI...
Significance MRI-guided high-intensity focused ultrasound (MR-HIFU) is noninvasive technology able to focally heat tumor tissue from hyperthermic up ablative temperatures. Although temperatures can be used destroy cancerous directly, adequate ablation of margins often impossible due the vicinity vital structures, leaving a potential source for local recurrence. Another therapeutic option in oncology hyperthermia-triggered drug delivery using MR-HIFU combination with temperature-sensitive...
Abstract The cardiac muscle architecture lies at the basis of mechanical and electrical properties heart, dynamic alterations in fiber structure are known to be prime importance healing remodeling after myocardial infarction. In this study, left ventricular was characterized using diffusion tensor imaging (DTI) a mouse model Myocardial infarction induced mice by permanent ligation anterior descending coronary artery. Serial ex vivo DTI measurements were performed 7, 14, 28, 60 days ligation....
Abstract High‐resolution magnetic resonance imaging (MRI) has evolved into one of the major non‐invasive tools to study healthy and diseased mouse heart. This presents a Cartesian CINE MRI protocol based on fast low‐angle shot sequence with navigator echo generate cardiac triggering respiratory gating signals retrospectively, making use ECG leads motion sensors obsolete. in vivo heart using this resulted images no detectable artefacts. The retrospective method allows for steady‐state heart,...
Purpose: We report on the design, performance, and specifications of a dedicated set‐up for treatment rats clinical magnetic resonance high intensity focused ultrasound (MR‐HIFU) system.Materials methods: The small animal HIFU‐compatible 4‐channel MR receiver volume coil support were designed as add‐on to 3T Philips Sonalleve MR‐HIFU system. Prolonged hyperthermia (T ≈ 42°C, 15 min) thermal ablation = 65°C) was performed in vivo subcutaneous rat tumours using 1.44 MHz acoustic frequency....
Objectives The aim of this study was to investigate the intratumoral distribution a temperature-sensitive liposomal carrier and its encapsulated compounds, doxorubicin, magnetic resonance (MR) imaging contrast agent after high-intensity focused ultrasound (HIFU)–mediated hyperthermia-induced local drug release. Materials Methods 111In-labeled liposomes encapsulating doxorubicin [Gd(HPDO3A) (H2O)] were injected intravenously in tail vein rats (n = 12) bearing subcutaneous rhabdomyosarcoma...
PET has become an important noninvasive imaging technique in cardiovascular research for the characterization of mouse models vivo. This modality offers unique insight into biochemical changes on a molecular level, with excellent sensitivity. However, morphologic and functional may be equal importance thorough assessment left ventricular (LV) pathophysiology. Although echocardiography MRI are widely considered techniques choice these parameters, their use considerably increases study...
Smoothelins are actin-binding proteins that abundantly expressed in healthy visceral (smoothelin-A) and vascular (smoothelin-B) smooth muscle. Their expression is strongly associated with the contractile phenotype of muscle cells. Analysis mice lacking both smoothelins (Smtn-A/B(-/-) mice) previously revealed a critical role for smoothelin-A intestinal contraction. Here, we report on generation cardiovascular only smoothelin-B (Smtn-B(-/-)).Myograph studies capacity saphenous femoral...
Abstract Purpose To compare global functional parameters determined from a stack of cinematographic MR images mouse heart by manual segmentation and an automatic algorithm. Materials Methods The results 22 hearts were compared. was based on propagation minimum cost algorithm in polar space starting manually drawn contours one phase. Intra‐ interobserver variability as well validity the determined. test reproducibility calculated intra‐ input. Results mean time for dataset around 10 minutes...
Purpose: In local hyperthermia, precise temperature control throughout the entire target region is key for swift, safe, and effective treatment. this article, we present a model predictive (MPC) algorithm providing voxel-level in magnetic resonance-guided high intensity focused ultrasound (MR-HIFU) assess improvement performance it provides over current state of art.Materials methods: The influence detail on prediction quality runtime controller evaluated tissue mimicking phantom...
For the clinical application of high intensity focused ultrasound (HIFU) for thermal ablation malignant tumors, accurate treatment evaluation is key importance. In this study, we have employed a multiparametric MRI protocol, consisting quantitative T 1 , 2 ADC, amide proton transfer (APT), 1ρ and DCE‐MRI measurements, to evaluate MR‐guided HIFU subcutaneous tumors in rats. K ‐means clustering using all different combinations endogenous contrast parameters (feature vectors) was performed...
Heating cancer cells over an extended period of time, referred to as hyperthermia, has been proven enhance the effects chemotherapy and radiotherapy without inducing additional toxicity or undesirable side effects, is therefore considered a highly valuable adjuvant therapy in treatment. In this work, model predictive control (MPC) setup developed for improving performance robustness regulating temperature magnetic-resonance-guided high-intensity focused ultrasound (MR-HIFU) hyperthermia...
Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) is a method to heat lesions noninvasively stable, elevated temperature and well-suited induce local hyperthermia (41°C-43°C) in deep-seated tissues. Resonance (MR) imaging provides therapy planning on anatomical images offers feedback based near-real-time MR thermometry. Although constant acquisition of thermometry data crucial ensure prolonged hyperthermia, it limits the freedom perform measurements other parameters,...
Purpose To demonstrate that proton resonance frequency shift MR thermometry (PRFS‐MRT) acquisition with nonselective free induction decay (FID), combined coil sensitivity profiles, allows spatially resolved B 0 drift‐corrected thermometry. Methods Phantom experiments were performed at 1.5T and 3T. Acquisition of PRFS‐MRT FID during MR‐guided high‐intensity focused ultrasound heating. The phase the FIDs was used to estimate change in angular δω drift per element. Two correction methods...
Purpose This article will report results from the in-vivo application of a previously published model-predictive control algorithm for MR-HIFU hyperthermia. The purpose investigation was to test controller’s performance and behavior in presence heterogeneous perfusion.Materials methods Hyperthermia at 42°C induced maintained up 30 min circular section thermometry slice biceps femoris German landrace pigs (n=5) using commercial system recently developed MPC algorithm. heating power allocation...
Purpose Pancreatic cancer is typically diagnosed in a late stage with limited therapeutic options. For those patients, ultrasound-guided high-intensity focused ultrasound (US-HIFU) can improve local control and alleviate pain. However, MRI-guided HIFU (MR-HIFU) has not yet been studied extensively this context. To facilitate related research accelerate clinical translation, we report workflow for the vivo ablation of porcine pancreas under MRI guidance.Materials methods The pancreases five...
Although promising results have been reported for Magnetic Resonance image-guided High-Intensity Focused Ultrasound (MR-HIFU) treatment of uterine fibroids, this is not yet widely implemented in clinical practice. During the implementation a new technology, lessons are learned and an institutional learning-curve often has to be completed. The primary aim our prospective cohort study was characterize based on outcomes. Secondary aims included identifying during MR-HIFU technical, patient...