A5050516725- Liver Disease Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Allelopathy and phytotoxic interactions
- Drug-Induced Hepatotoxicity and Protection
- Drug Transport and Resistance Mechanisms
- Diet and metabolism studies
- Weed Control and Herbicide Applications
- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Glycogen Storage Diseases and Myoclonus
- Biochemical Acid Research Studies
- Plant Stress Responses and Tolerance
- Natural Antidiabetic Agents Studies
- Pharmacogenetics and Drug Metabolism
- Nanoplatforms for cancer theranostics
- Metabolomics and Mass Spectrometry Studies
- Biochemical effects in animals
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Biological Activities
- Agricultural and Food Sciences
- Estrogen and related hormone effects
- Neuroscience and Neuropharmacology Research
- Photosynthetic Processes and Mechanisms
Universidade Estadual de Maringá
2016-2025
Inserm
2013
The University of Tokyo
2013
The cover crop Pennisetum glaucum (L.) R.Br. (pearl millet) reduces the emergence of weed species in field through a mechanism that is not fully known. identification allelopathic activity pearl millet can contribute to development no-tillage techniques produce crops without or with low doses herbicides. This issue was investigated by testing effects extracts from aerial parts on germination and growth weeds Bidens pilosa L., Euphorbia heterophylla Ipomoea grandifolia (Dammer) O’Donell under...
Adjuvant-induced arthritis is an experimental immunopathology in rats that often used as a model for studying autoimmune chronic inflammation and inflammatory cachexia. In these animals oxidative stress quite pronounced the articular sites. The purpose of this study was to evaluate liver arthritic which morphological metabolic alterations have been reported occur. Oxidative injury parameters, levels production reactive oxygen species (ROS), antioxidant parameters were measured total...
The flavonolignan silibinin, which is a mixture of two diastereoisomers, silybin A and B, component the extract obtained from fruit seeds variegated milk thistle (Silybum marianum (L.) Gaertn. (Asteraceae)), known as silymarin. Among therapeutic properties credited to its antihyperglycaemic action has been extensively explored. Silibinin structurally related flavonoids quercetin fisetin, have previously demonstrated be very active on liver metabolic processes glycaemic regulation. aim...
According to the literature, methylene blue (MB) is a photosensitizer (PS) with high affinity for mitochondria. Therefore, several studies have explored this feature evaluate its photodynamic effects on mitochondrial apoptotic pathway under normoxic conditions. We are aware only of limited reports regarding MB's energy metabolism, especially hypoxic Thus, purposes study were determine direct and acute MB metabolism rat liver mitochondria conditions parameters linked in isolated perfused...
Fisetin is a flavonoid dietary ingredient found in the smoke tree (Cotinus coggyria) and several fruits vegetables. The effects of fisetin on glucose metabolism isolated perfused rat liver some glucose-regulating enzymatic activities were investigated. inhibited glucose, lactate, pyruvate release from endogenous glycogen. Maximal inhibitions glycogenolysis (49%) glycolysis (59%) obtained with concentration 200 microM. glycogenolytic glucagon dinitrophenol suppressed by 300 No significant...
Sorghum, pearl millet, and Brachiaria ruziziensis have similar characteristics which led to their use for mulch formation in no-till systems. This study was carried out evaluate the potential of these three species as straw suppliers suppress weed emergence. Initial findings conclusion that both millet or superior suppressors, compared sorghum straw, a with recognized allelopathic potential. Subsequently, new trials were conducted under greenhouse conditions by sowing pots, followed covering...
Primary hepatocyte culture is an important in vitro system for the study of liver functions. In vivo , hepatocytes have high oxidative metabolism. However, oxygen supply by means diffusion static cultures much less than that blood circulation . Therefore, we investigated whether hypoxia contributes to dedifferentiation and deregulated metabolism cultured hepatocytes. To this end, murine were under or shaken (60 revolutions per minute) conditions a collagen sandwich. The effect on was...
Melatonin has been shown to protect cells against oxidative and inflammatory damage via endocrine, paracrine autocrine actions. Postmenopausal condition is associated with a high incidence of many features metabolic syndrome including obesity, steatosis liver injuries. The aim this work was investigate whether treatment melatonin improves disturbances oestrogen deficiency in ovariectomised (OVX) rats. OVX control (CON) female rats were treated (10 mg/kg × day for 3 weeks, p.o.). Body weight...
The mechanisms by which monoterpenes released certain species affect the germination and growth of other plants remain to be elucidated. information that is currently available suggests they interfere with some physiological processes, including respiration, mitosis, action phytohormones, antioxidant defence systems membrane properties. data obtained our group from literature have enabled us propose a mechanism for α-pinene, most active monoterpene has been identified in works. α-Pinene acts...
The aim of this work was to evaluate the effects therapeutic doses Cimicifuga racemosa on cardiovascular parameters and liver lipid metabolism redox status in an animal model estrogen deficiency associated with hypertension, a condition that could make more vulnerable drug-induced injuries. Female Wistar rats were subjected surgical procedures bilateral ovariectomy (OVX) induction renovascular hypertension (two-kidneys, one-clip; 2K1C). These animals (OVX + 2K1C) treated daily C. extract,...
The aim of this work was to evaluate the changes caused by estrogen deficiency in lipid metabolism. This study encompassed direct measurements plasma biochemical analyses, liver contents, and assessments mitochondrial β-oxidation capacity as well an evaluation redox status animal model deficiency. When compared with control mice, livers ovariectomized (OVX) mice presented considerable accretions their which were accompanied increased levels peroxidation homogenates mitochondria from OVX...