A5064209161- Contact Dermatitis and Allergies
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Occupational exposure and asthma
- Pesticide Exposure and Toxicity
- Olfactory and Sensory Function Studies
- Nail Diseases and Treatments
- Animal testing and alternatives
- Skin Protection and Aging
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Vitamin C and Antioxidants Research
- Herbal Medicine Research Studies
- Microscopic Colitis
- Psychedelics and Drug Studies
- Skin and Cellular Biology Research
- Celiac Disease Research and Management
Gentofte Hospital
2016-2024
Copenhagen University Hospital
2023
University of Copenhagen
2016-2017
For cosmetics, it is mandatory to label 26 fragrance substances, including all constituents of mix I (FM I) and II II). Earlier reports have not included oxidized R-limonene [hydroperoxides (Lim-OOH)] linalool (Lin-OOH)], breakdown testing FM has mainly been performed in selected, mix-positive patients.To report the prevalence sensitization fragrances, assess concomitant reactivity and/or II.A cross-sectional study on consecutive dermatitis patients patch tested with fragrances European...
More than 25% of the adult European population suffers from contact allergy, with fragrance substances recognized as one main causes. Since 2005, 26 allergens have been mandatory to label in cosmetic products within EU if present at 10 ppm or above leave-on and 100 wash-off cosmetics.To examine exposure, based on ingredient labelling, fragrances a sample 5588 fragranced products.The investigated were identified through novel, non-profit smartphone application (app), designed provide...
Background Contact allergy to oxidized limonene, with hydroperoxides of limonene (Lim‐OOHs) as the main allergens, is common. However, high proportions weak positive and doubtful patch test reactions have been reported. Objectives To determine clinical relevance, elicitation threshold dose‐response relationship Lim‐OOHs in individuals a or reaction standard 0.3% pet. Methods A multicentre 3‐week double‐blind vehicle‐controlled repeated open application (ROAT) study simulated fine fragrance...
For more than 30 years, fragrance mix I (FMI) has been the most important screening marker for contact allergy. Meanwhile, governmental and corporate initiatives have implemented, aimed at reducing sensitization to allergens, including single constituents of FMI.To examine trends in allergy FMI from 1986 2015 patients with dermatitis, test hypothesis that decreased within recent years.This was a cross-sectional registry study on patch results among consecutively tested dermatitis university...
Summary Background Sorbitan sesquioleate ( SSO ) has been added to fragrance mix I FM as an emulsifier since the 1990s. Being a contact allergen itself, potential cause false‐positive reactions . Recent results obtained with selected ‐positive patients have shown that 5% concomitant positive Objectives To investigate 5‐year prevalence of allergy and evaluate importance when patch test for are interpreted. Methods This was retrospective database study consecutively tested eczema (n = 4 6 3 7)...
Fragrance contact allergy is common, but few studies on quality of life (QoL) in affected patients exist. Recently, the disease-specific Quality Life Index (FQLI) was developed.To characterize QoL European dermatitis with fragrance at time diagnosis.This a cross-sectional study, which 2011 Danish, British, Spanish and German adult consecutive were invited to complete questionnaire self-reported disease severity, Dermatology (DLQI), FQLI immediately prior being patch tested.One thousand seven...
Summary Background Contact allergy to linalool hydroperoxides (Lin‐ OOHs ) and limonene (Lim‐ is common. Similarly what occurs with the terpene hydroperoxides, reactive intermediates formed from p ‐phenylenediamine ( PPD can cause oxidative modifications of tryptophan residues on proteins in mechanistic studies. Objectives To test hypothesis that patients sensitized are at increased risk concomitant reactivity either owing a ‘common pathway’ skin protein oxidation. Methods A database study...
The authors have no conflicts of interest to report.