A5101683720- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Nitric Oxide and Endothelin Effects
- Blood Pressure and Hypertension Studies
- Blood Coagulation and Thrombosis Mechanisms
- Hemodynamic Monitoring and Therapy
- Health Systems, Economic Evaluations, Quality of Life
- Lipoproteins and Cardiovascular Health
- Heart Rate Variability and Autonomic Control
- Cardiac pacing and defibrillation studies
- Peripheral Artery Disease Management
- Heart Failure Treatment and Management
- Cardiovascular and exercise physiology
- Pharmaceutical Economics and Policy
- Inflammatory Bowel Disease
- Renin-Angiotensin System Studies
- Cardiac Arrhythmias and Treatments
- Cardiac Arrest and Resuscitation
- Parvovirus B19 Infection Studies
- Autoimmune and Inflammatory Disorders Research
- Cardiac Imaging and Diagnostics
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Function and Risk Factors
- Colorectal Cancer Treatments and Studies
Camden and Campbelltown Hospitals
2007-2024
Liverpool Hospital
2007-2023
Western Sydney University
2011-2021
South Western Sydney Local Health District
2020-2021
UNSW Sydney
2021
Montreal Clinical Research Institute
1992-2018
Centre Hospitalier de l’Université de Montréal
2016-2018
Hotel Dieu Hospital
2005-2013
Hôtel-Dieu de Montréal
2013
Saint Joseph Hospital
2013
Patients who have a first episode of venous thromboembolism in the absence known risk factors for thrombosis (idiopathic thrombosis) are often treated with anticoagulant therapy three months. Such patients may benefit from longer treatment, however, because they appear to an increased recurrence after is stopped.
Warfarin is very effective in preventing recurrent venous thromboembolism but also associated with a substantial risk of bleeding. After three months conventional warfarin therapy, lower dose anticoagulant medication may result less bleeding and still prevent thromboembolism.
The risk of recurrence is lower after treatment an episode venous thromboembolism associated with a transient factor, such as recent surgery, than permanent, or no, factor. Retrospective analyses suggest that 1 month anticoagulation adequate for patients whose thromboembolic event was provoked by factor.In this double-blind study, who had completed anticoagulant therapy first factor were randomly assigned to continue warfarin placebo additional 2 months. Our goal determine if the duration...
To compare the acute and chronic effects of nifedipine retard (NPA), gastrointestinal therapeutic system (NGITS) amlodipine at trough peak plasma concentrations drug on blood pressure heart rate, norepinephrine epinephrine levels in patients with mild-to-moderate hypertension (diastolic 95-115 mmHg).After 3-4 weeks' placebo treatment, both sexes were randomly allocated to be administered 10 or 20 mg NPA twice a day, 30 60 NGITS once 5 day for 6 weeks. Initially, first 2 weeks, lowest dose...
The effects of beta-blockade on muscle utilization glycogen and triglycerides, as well potassium metabolism, were studied in eight healthy male subjects performing long-duration exercise to exhaustion. Subjects after treatment with either placebo (PLAC), beta 1-selective (atenolol, 100 mg/day, AT), or nonselective (nadolol, 80 NAD) each for 1 wk according a randomized, double-blind, cross-over design. NAD AT caused identical decreases heart rates, but endurance (71 +/- 8 min PLAC) decreased...
The sheared-flow-stabilized Z pinch concept has been studied extensively and is able to produce fusion-relevant plasma parameters along with neutron production over several microseconds. We present here elevated electron temperature results spatially temporally coincident the source. An optical Thomson scattering apparatus designed for FuZE device measures temperatures in range of 1–3 keV on axis device, 20 cm downstream nose cone. 17-fiber system radial profiles temperature. Scanning laser...
Kearon, Clive; Ginsberg, Jeffrey S.; Kovacs, Michael J.; Anderson, David R.; Wells, Philip; Julian, Jim A.; MacKinnon, Betsy; Weitz, I.; Crowther, Mark Dolan, Sean; Turpie, Alexander G.; Geerts, William; Solymoss, Susan; van Nguyen, Paul; Demers, Christine; Kahn, Susan Kassis, Jennine; Rodger, Marc; Hambleton, Julie; Gent,
The vasoconstrictor effect, the binding, and response of inositol phosphates to endothelin-1 (ET-1) were investigated in blood vessels deoxycorticosterone acetate (DOCA)-salt hypertensive rats within 2 weeks development hypertension uninephrectomized control rats. In DOCA-salt rats, plasma levels endothelin similar (1.2 +/- 0.1 fmol/ml). Thoracic aorta mesenteric artery rings devoid endothelium presented significantly decreased responses increasing concentrations ET-1. Binding ET-1 membranes...
To evaluate the long-term clinical and hemodynamic effectiveness of aortic stent placement in cases failure intended infrarenal percutaneous transluminal angioplasty (PTAA).Fifty-three patients who underwent technically successful PTAA were compared with 24 because (19 patients) or ulcerated lesions (five that otherwise would have been treated surgically embolization hazard associated alone. Clinical patency was defined as absence improvement symptoms after intervention. Hemodynamic a normal...
Cardiac resynchronization therapy (CRT) is a treatment for heart failure (HF) that improves cardiac, functional, and quality of life (QoL) outcomes. This study was designed to examine the effect addition CRT (CRTD) implantable cardioverter defibrillator (ICD) on psychological functioning.Overall, 99 participants completed batteries before 9 months after ICD or CRTD implantation in registry HF patients receiving device 3 US centers. Measures included validated indices mental health (State...
Trial economic analyses, such as cost-effectiveness analysis, often rely on trial-collected data, which are burdensome and expensive to collect may be incomplete. In contrast, administrative databases systematically health system encounters. We investigated whether data could improve the performance of cancer trial analysis.Health were probabilistically linked Ontario patient from Canadian Cancer Trials Group CO.17 (n = 572), evaluated cetuximab plus best supportive care (75 patients) versus...
The contractile responses and generation of intracellular second messengers in response to endothelin-1 (ET-1), a potent vasoconstrictor peptide released locally by endothelial cells involved the regulation vascular tone, were investigated different segments tree adult 18-week-old spontaneously hypertensive rats (SHR) as compared with age-matched Wistar–Kyoto (WKY) rats. Aorta rings SHR showed lower maximum ET-1 comparison WKY Rings main superior mesenteric artery similar ET-1. Small...
In previous studies a decreased responsiveness to endothelin-1 (ET-1) of conduit arteries and resistance vessels deoxycorticosterone acetate (DOCA)-salt hypertensive rats was found in comparison with uninephrectomized controls. Decreased isometric force, number receptors, inositol phosphate accumulation were reported the DOCA-salt animals. present study effects ET-1 on cytosolic free calcium, phosphates, 1,2-diacylglycerol investigated blood rats. Basal measured fluorescent dye fura-2, 201...
Statin therapy is presented as a protection against ischemic heart disease (IHD) complications. As IHD often fatal disease, statins are thereby supposed to decrease cardiovascular mortality and increase life expectancy. However, these benefits increasingly challenged in the medical community, controversy being particularly intense when discussing effects of primary prevention consequences statin discontinuation. Both treatment discontinuation have been recently used by investigators linked...
To assess the effects of age on responsiveness atrial natriuretic factor (ANF) release, and possible contribution cardiac sympathetic activity, in young (n = 8) older normotensives 7), volume load plasma ANF, central venous pressure, general hemodynamics were evaluated. Studies performed after pretreatment with placebo or 80 mg propranolol. Cardiac loading increased pressure by 3–5 mmHg (1 133.3 Pa); β-blockade did not affect this response. caused significant increases heart rate (10–15...
Records of changes in cholesterol can show whether patients are receiving intervention or not—biasing trials to make statins look more beneficial than they really are, argues <b>Paul v Nguyen</b>