A5068958931- Click Chemistry and Applications
- Cyclopropane Reaction Mechanisms
- Synthesis and Catalytic Reactions
- Geology and Paleoclimatology Research
- Geochemistry and Elemental Analysis
- Hydrocarbon exploration and reservoir analysis
- Geological and Geophysical Studies
Imperial College London
2021
Vinyl sulfones and sulfonamides are valued for their use as electrophilic warheads in covalent protein inhibitors. Conversely, the S(VI) aza-isosteres thereof, vinyl sulfoximines sulfonimidamides, far less studied have yet to be applied field of bioconjugation. Herein, we report a range different synthetic methodologies constructing sulfoximine sulfonimidamide architectures that allows access new areas chemical space. We demonstrate how late-stage functionalization can these motifs...
Vinyl sulfones and sulfonamides are valued for their use as electrophilic warheads in covalent protein inhibitors. Conversely, the S(VI) aza-isosteres thereof, vinyl sulfoximines sulfonimidamides, far less studied have yet to be applied field of bioconjugation. Herein, we report a range different synthetic methodologies constructing sulfoximine sulfonimidamide architectures that allows access new areas chemical space. We demonstrate how late stage functionalization can these motifs...
Vinyl sulfones and sulfonamides are valued for their use as electrophilic warheads in covalent protein inhibitors. Conversely, the S(VI) aza-isosteres thereof, vinyl sulfoximines sulfonimidamides, far less studied have yet to be applied field of bioconjugation. Herein, we report a range different synthetic methodologies constructing sulfoximine sulfonimidamide architectures that allows access new areas chemical space. We demonstrate how late stage functionalization can these motifs...