A5090377323- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Neurotransmitter Receptor Influence on Behavior
- Anesthesia and Pain Management
- Pharmacological Receptor Mechanisms and Effects
- Advanced Chemical Sensor Technologies
- Inflammatory mediators and NSAID effects
- Bioinformatics and Genomic Networks
- Analytical chemistry methods development
- Pain Management and Opioid Use
- Olfactory and Sensory Function Studies
- Opioid Use Disorder Treatment
- Alcohol Consumption and Health Effects
- Tryptophan and brain disorders
- Genetic Associations and Epidemiology
- Artificial Intelligence in Healthcare and Education
- Neuroinflammation and Neurodegeneration Mechanisms
- Estrogen and related hormone effects
- Spine and Intervertebral Disc Pathology
- Neuroscience and Neuropharmacology Research
- Monoclonal and Polyclonal Antibodies Research
- Mental Health Research Topics
- Long-Term Effects of COVID-19
Icahn School of Medicine at Mount Sinai
2023-2025
Center for Neuro-Oncology
2025
Allen Institute for Brain Science
2023-2024
Mount Sinai Hospital
2022
Stanford University
2018-2021
Arista (United States)
2021
University of Washington
2014-2015
Temple University
2000-2010
Prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) couples to stimulation of adenylyl cyclase through two distinct G protein-coupled receptors designated EP2 and EP4. Although they have similar affinities for PGE<sub>2</sub>, the EP<sub>2</sub> EP4 structural characteristics. is a 358-amino-acid protein with short third intracellular loop C-terminal domains, whereas consists 488 amino acids long cytoplasmic tail. The ability HA epitope-tagged undergo PGE<sub>2</sub>-induced internalization was...
A major advancement in the field of analgesic pharmacology has been development G-protein-biased opioid agonists that display less respiratory depression than conventional drugs. It is uncertain, however, whether these new drugs cause tolerance, hyperalgesia, and other maladaptations when administered repeatedly.The archetypical µ-opioid receptor agonist morphine and, separately, oliceridine were to mice. These used models acute analgesia, opioid-induced reward, physical dependence. In...
Chronic postsurgical pain (CPSP) is a global issue with high prevalence. This study compared acute descriptors among patients undergoing carpal tunnel release (CTR) or trigger finger (TFR). We hypothesized worst intensity on postoperative day (POD) 10 would be best to predict the time resolution. In this secondary analysis of negative, randomized, double-blind placebo-controlled trial, adult veterans CTR TFR were enrolled January 2012–January 2014, data February 2020–October 2020....
Polydimethylsiloxane (PDMS)-based solid-phase micro-extraction (SPME) was used along with Raman spectroscopy (RS) to separate and enhance the detection of five anesthetic compounds (halothane, propofol, isoflurane, enflurane, etomidate) from aqueous serum phases. signals in spectral ranges 250–450 cm −1 950–1050 allowed unique characterization all when extracted into PDMS phase. The SPME-RS clinically relevant concentrations propofol (6.5 μM) halothane (200 is shown. We quantify partition...
Repeated administration of cocaine induces heightened behavioral hyperactivity termed sensitization. Although NK-3 receptors have been shown to modulate acute cocaine-induced behaviors, their role in sensitization is unknown. The present study investigated whether receptor blockade altered cocaine. Additionally, glycogen synthase kinase-3 (GSK3) has be involved dopamine signaling and development sensitization; therefore regulation GSK3 activity the nucleus accumbens was also investigated....
Persistent use of prescription opioids beyond the period surgical recovery is a large part public health problem linked to current opioid crisis in United States. However, few studies have been conducted examine whether morphine reward influenced by acute pain and injury.In mouse model incisional injury minor trauma, animals underwent conditioning, extinction, drug-primed reinstatement with rewarding properties presence drug-induced relapse, respectively. In addition, we sought determine...
OBJECTIVES/GOALS: Using biomarkers to identify vulnerabilities from cocaine use disorder (CUD) is a focus of recent investigations. Current clinical efforts on psychiatric recovery in CUD, however other body systems are missed. Applying blood-based transcriptomics investigate how conditions relate CUD can alter current treatment approaches. METHODS/STUDY POPULATION: We conducted comprehensive longitudinal study 12 individuals (mean 53 yrs.; M/F ratio 9: 3) with abstinent cocaine. 44 blood...
Abstract Background Individuals with cocaine use disorder (CUD) who attempt abstinence experience craving and relapse, which poses challenges in treatment. Longitudinal studies linking behavioral manifestations CUD to the blood transcriptome living individuals are limited. Therefore, we investigated connection between drug behaviors during transcriptomics. Methods We conducted a comprehensive longitudinal study involving 12 subjects (9 males, 3 females) RNA sequencing on collected at...
Objective In light of the opioid epidemic, there is a need to identify factors that predict aberrant behaviors including misuse and abuse. Impulsivity has been extensively studied in addiction literature, but not context misuse. Hence, this study aimed which impulsivity facets (negative urgency, positive sensation seeking, lack perseverance, premeditation) would current opioid-related patients with chronic pain.Methods Data were collected through an online survey from pain who visited...
Recent reports suggest pain from surgical injury may influence the risks associated with exposure to opioids. In mice, hind-paw incision attenuates morphine-primed reinstatement due kappa opioid receptor activation by dynorphin. this focused group of studies, we examined hypotheses that kappa-opioid in nucleus accumbens mediates attenuated drug- primed after incisional surgery, and G-protein biased mu-opioid agonist, oliceridine, leads less priming dynorphin effect comparison morphine. To...