A5073308601- Cholinesterase and Neurodegenerative Diseases
- Pesticide Exposure and Toxicity
- Electrochemical sensors and biosensors
- Computational Drug Discovery Methods
- Bacillus and Francisella bacterial research
- Insect and Pesticide Research
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Environmental Toxicology and Ecotoxicology
- Electrochemical Analysis and Applications
- bioluminescence and chemiluminescence research
- Nicotinic Acetylcholine Receptors Study
- Advanced Chemical Sensor Technologies
- Advanced Biosensing Techniques and Applications
- Analytical Chemistry and Sensors
- Chemical synthesis and alkaloids
- Yersinia bacterium, plague, ectoparasites research
- Acoustic Wave Resonator Technologies
- Medicinal Plants and Neuroprotection
- Bacteriophages and microbial interactions
- Aquatic Ecosystems and Phytoplankton Dynamics
- Tryptophan and brain disorders
- Free Radicals and Antioxidants
- Circadian rhythm and melatonin
- Microbial Inactivation Methods
University of Defence
2016-2025
University Surgical Associates
2021
Mendel University in Brno
2013-2018
Central European Institute of Technology
2012-2017
Brno University of Technology
2012-2017
University of Pardubice
2016-2017
Karel Englis College
2013-2015
University of Defence
2013
European Union
2011-2012
University Hospital Hradec Králové
2010-2012
The first scientifically proposed as well successfully commercialized biosensors were those based on electrochemical sensors for multiple analytes. Electrochemical have been studied a long time. Currently, transducers semiconductors and screen printed electrodes represent typical platform the construction of biosensors. Enzymes or enzyme labeled antibodies are most common biorecognition components principles of, applications described in this review. relevant systems divided into three types...
Assay of acetylcholinesterase (AChE) activity plays an important role in diagnostic, detection pesticides and nerve agents, vitro characterization toxins drugs including potential treatments for Alzheimer’s disease. These experiments were done order to determine whether indoxylacetate could be adequate chromogenic reactant AChE assay evaluation. Moreover, the results compared standard Ellman’s method. We calculated Michaelis constant Km (2.06 × 10−4 mol/L acetylthiocholine 3.21 10−3...
Electrochemical methods provide high potential for investigation of antioxidant compounds, assessment capacity, and measurement electrochemical index. Different types electrodes can be used the assay purposes. The devices stationary or flow through, based on cyclic differential pulse voltammetry as well potentiostatic analysis. are known their suitability food control monitoring levels capacity in other biological samples matrices. In this review, application both analysis plant clinical...
The absence of low-thermal gradients in old metamorphic rocks (<350 °C GPa-1) has been used to argue for a fundamental change the style plate tectonics during Neoproterozoic Era. Here, we report data from an eclogite xenolith Paleoproterozoic carbonatite North China craton that argues cold subduction as early 1.8 Ga. sediment-derived C isotope signature and enriched initial Sr-Nd composition, indicative ocean-crust components source. records peak pressures 2.5-2.8 GPa at 650-670 °C,...
Caffeine is an alkaloid with a stimulant effect in the body. It can interfere transmissions based on acetylcholine, epinephrine, norepinephrine, serotonin, dopamine and glutamate. Clinical studies indicate that it be involved slowing of Alzheimer disease pathology some other effects. The effects are not well understood. In present work, we focused question whether caffeine inhibit acetylcholinesterase (AChE) and/or, butyrylcholinesterase (BChE), two enzymes participating cholinergic...
Biosenzory jsou jednoducha a přesna analyticka zařizeni použivana od poloviny 20. stoleti. Toto review se zaměřuje na popis konstrukce biosenzorů s praktickými přiklady. Diskutovany nejpouživanějsi biorekognicni elementy (enzymy, protilatky, buňky atd.), imobilizacni techniky fyzikalně-chemicke převodniky. Rovněž uvedeny soucasne trendy v analýzach biosenzory, nove materialy pricipy, přiklady neobvyklých biosenzorů.
Alzheimer´s disease (AD) is a progressive neurodegenerative dementia which currently represents one of the biggest threats for human kind. The cure still unknown and various hypotheses (cholinergic, amyloidal, oxidative, vascular etc.) are investigated in order to understand pathophysiology on this basis find an effective treatment. Tacrine, first approved drug AD treatment, has been reported be multitargeted drug, however it was withdrawn from market particularly due its hepatotoxicity. Its...