A5010024716- Gut microbiota and health
- Probiotics and Fermented Foods
- Retinoids in leukemia and cellular processes
- GABA and Rice Research
- Clostridium difficile and Clostridium perfringens research
- Neuroendocrine regulation and behavior
- Nutrition, Genetics, and Disease
- Stress Responses and Cortisol
- Meat and Animal Product Quality
RIKEN Center for Integrative Medical Sciences
2021-2024
Keio University
2024
Persistent colonization and outgrowth of potentially pathogenic organisms in the intestine can result from long-term antibiotic use or inflammatory conditions, may perpetuate dysregulated immunity tissue damage
<title>Abstract</title> <bold>Persistent colonization and outgrowth of pathogenic organisms in the intestine may occur due to long-term antibiotic usage or inflammatory conditions, which perpetuate dysregulated immunity tissue damage</bold><sup><bold>1,2</bold></sup><bold>. Gram-negative </bold><italic><bold>Enterobacteriaceae</bold></italic><bold> gut pathobionts are particularly recalcitrant conventional treatment</bold><sup><bold>3,4</bold></sup><bold>, though an emerging body evidence...
Abstract Recent studies using germ-free mice have demonstrated that microbiota functional roles in host homeostasis1,2. However, the phylogenetic distance between rodents and humans translates into differences their metabolism, immune response, neural function colonisation abilities. Hence, translational research nonhuman primates (NHPs) is important for bridging gap rodent human medicine3. Although several attempts to produce NHPs were made more than 50 years ago4,5, currently none are...
Activation of brown and beige fat biogenesis promotes metabolic health in rodents humans, but typically requires cold exposure or pharmacological activation β-adrenergic receptors, which may pose cardiovascular risks. Dietary intervention represents a clinically viable alternative strategy to induce cells thus enhance health, though the underlying mechanisms remain poorly understood. In this study, we identified specific microbiota members both mice humans that promote browning white adipose...