A5006051941- Emergency and Acute Care Studies
- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Prostate Cancer Treatment and Research
- Hormonal and reproductive studies
- Birth, Development, and Health
- Orthopaedic implants and arthroplasty
- Glioma Diagnosis and Treatment
- Health Literacy and Information Accessibility
- Total Knee Arthroplasty Outcomes
- Bone health and treatments
- Hip disorders and treatments
- Healthcare Policy and Management
- Colorectal Cancer Treatments and Studies
- Brain Metastases and Treatment
- Prostate Cancer Diagnosis and Treatment
- Fatty Acid Research and Health
- Chronic Lymphocytic Leukemia Research
- Medical Imaging and Pathology Studies
- Estrogen and related hormone effects
- Healthcare Systems and Technology
- Cardiac, Anesthesia and Surgical Outcomes
- Mobile Health and mHealth Applications
- Childhood Cancer Survivors' Quality of Life
- Chronic Disease Management Strategies
Université Laval
2016-2025
Centre hospitalier universitaire de Québec
2015-2025
The Quebec Population Health Research Network
2024
Wilfrid Laurier University
2024
Centre hospitalier de l'Université Laval
2020-2024
Institute for Clinical Evaluative Sciences
2022
Peoples' Friendship University of Russia
2022
Simon Fraser University
2021
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2020
Laval Mayenne Technopole
2020
Objective. Microparticles (MP) are small extracellular vesicles present in body fluids. MP originate from different cellular lineages, principally platelets blood, and may expose phosphatidylserine (PS). In systemic lupus erythematosus (SLE), harbor immunoglobulin G (IgG), thereby forming MP-containing immune complexes (mpIC). We aimed to verify an association between SLE disease activity, damage, surrogate markers of atherosclerosis harboring IgG, taking into account the platelet origin PS...
The interdependence of cytokines and appetite-modifying hormones implicated in cancer anorexia-cachexia syndrome (CACS) remains unclear. This study aimed to regroup these into distinct inflammatory (or non-inflammatory) pathways determine whether can classify patients with CACS phenotypes.
Introduction: A physician handoff is the process through which physicians transfer primary responsibility of a care unit. The emergency department (ED) fast-paced and crowded environment where risk information loss between shifts significant. Yet, impact handoffs on patient outcomes remains understudied. We performed retrospective cohort study in ED to determine if handed-off patients, when compared non-handed-off were at higher negative outcomes. Methods: included every adult first assessed...
ABSTRACT Bisphosphonate use has been associated with atypical femoral fractures (AFFs), defined by the American Society of Bone and Mineral Research (ASBMR) Task Force criteria, which currently exclude periprosthetic fractures. The objectives this study were to establish prevalence (APFFs) in patients hip knee arthroplasties determine clinical radiological risk factors these We performed a retrospective review all between January 1, 2006, March 31, 2015, Quebec City, Canada. Patients who...
Physical activity (PA) during pregnancy might contribute to reduce neonatal adiposity, a predictor of metabolic disturbances.The objective the study was evaluate association between maternal PA intensity and body composition.Maternal measured by accelerometry nutrition were documented pregnancy, as well composition dual-energy X-ray absorptiometry following delivery. Associations at 17 36 weeks (time spent in moderate (MPA), vigorous (VPA) status their interaction) addressed multivariate...
Introduction The localization, density but mostly the phenotype of tumor infiltrating lymphocytes (TIL) provide important information on initial interaction between host immune system and tumor. Our objective was to assess prognostic significance T (CD3 + ), regulatory (T reg ) (FoxP3 memory mem (CD45RO genes associated with TIL in prostate cancer (PCa). Methods Immunohistochemistry (IHC) used infiltration CD3 , FoxP3 CD45RO cells area, margin adjacent normal-like epithelium a series 98 PCa...
The identification of factors involved in the postnatal growth preterm infants will help achieve similar to that term infants.As per protocol: compare body composition very at term-corrected age (TCA) with infants, and explore relationships between neonatal characteristics infants.Anthropometry, nutritional characteristics, outcomes were prospectively collected 26 (<29 weeks) 33 (37-40 infants. Body using dual-energy X-ray absorptiometry (DXA) was measured TCA days 7 10 infants.Parenteral...
Objectives Endometriosis (EM) is an estrogen-dominant inflammatory disease linked to infertility that affects women of reproductive age. EM lesions respond hormonal signals regulate uterine tissue growth and trigger inflammation pain. The objective this study was evaluate whether estradiol (E 2 ) its biologically active metabolites are differentially associated with given their estrogenic non-estrogenic actions including proliferative properties. Design We performed a retrospective 209 cases...
Abstract This study investigated the potential of single nucleotide polymorphisms as predictors survival in two cohorts comprising 417 metastatic colorectal cancer (mCRC) patients treated with FOLFIRI (folinic acid, 5-fluorouracil and irinotecan) regimen. The rs4806668G > T ribosomal protein gene RPL28 was associated shorter progression-free overall by 5 9 months ( P = 0.002), hazard ratios 3.36 < 0.001) 3.07 respectively. rs4806668T allele an increased expression transverse normal...
Context Recent evidence support that androgens play an important role in the etiology of endometrial cancer (EC). Adrenal-derived 11-oxygenated are highly potent agonists androgen receptor (AR), comparable to testosterone (T) and dihydrotestosterone (DHT) have not been studied context EC. Methodology We a cohort 272 newly diagnosed postmenopausal EC cases undergoing surgical treatment. Circulating concentrations seven including precursors, their metabolites were established serum samples...
Abstract Background Metabolic dependencies of chronic lymphocytic leukaemia (CLL) cells may represent new personalized treatment approaches in patients harbouring unfavourable features. Methods Here, we used untargeted metabolomics and lipidomics analyses to isolate metabolomic features associated with aggressive CLL poor survival outcomes. We initially focused on profiles overexpression the adverse metabolic marker glycosyltransferase (UGT2B17) drug resistance. Results Leukaemic B‐cell...
AIMTo test the safety and effectiveness of hypertonic saline solution (HSS + F) as a strategy for weight loss
Persistent pulmonary hypertension of the newborn (PPHN) occurs in 10% neonatal respiratory insufficiency. To selectively reduce vascular resistance, several treatments have been tried. Inhaled epoprostenol (iPGI2) has used for 12 years our institution management refractory PPHN despite gaps literature to support this use.The primary objective was evaluate efficacy iPGI2 PPHN. The secondary objectives were describe its use neonates and assess side effects.This retrospective cohort study...
Abstract Background Health literacy refers to the ability of individuals gain access to, use, and understand health information services in order maintain a good health. It is especially important nephrology due complexity chronic kidney disease (CKD). The present study sought define levels patients followed predialysis clinic, in-center dialysis (ICHD), peritoneal (PD) home hemodialysis (HHD). Methods This transversal monocentric observational analysed 363 between October 2016 April 2017....