A5004547660- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Telomeres, Telomerase, and Senescence
- Breast Cancer Treatment Studies
- interferon and immune responses
- Epigenetics and DNA Methylation
- SARS-CoV-2 detection and testing
- Gut microbiota and health
- Genetics, Aging, and Longevity in Model Organisms
- Oral microbiology and periodontitis research
- Breast Lesions and Carcinomas
- HER2/EGFR in Cancer Research
- Genetic Associations and Epidemiology
- Ear and Head Tumors
- Traumatic Brain Injury Research
- Cancer Treatment and Pharmacology
- Family and Disability Support Research
- MRI in cancer diagnosis
- Long-Term Effects of COVID-19
- Breast Implant and Reconstruction
- Inclusion and Disability in Education and Sport
- Bariatric Surgery and Outcomes
- Advanced Radiotherapy Techniques
- Genomics and Chromatin Dynamics
- Pluripotent Stem Cells Research
Orlando Health
2016-2024
Orlando Regional Medical Center
2016-2024
Jewish General Hospital
2020-2023
McGill University
2020-2022
Institute for Research in Immunology and Cancer
2020-2021
Université de Montréal
1982-2021
UF Health Cancer Center
2018-2021
University of Florida Health
2018-2021
Moffitt Cancer Center
2018
Virginia Commonwealth University
2007
niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français étrangers, laboratoires publics privés.
Abstract Telomere erosion in cells with insufficient levels of the telomerase reverse transcriptase ( TERT ), contributes to age‐associated tissue dysfunction and senescence, p53 plays a crucial role this response. We undertook genome‐wide CRISPR screen identify gene deletions that sensitized p53‐positive human inhibition. uncovered previously unannotated gene, C16ORF72 , which we term Attrition Response 1 TAPR1 exhibited synthetic‐sick relationship loss. A subsequent ‐disrupted reciprocally...
Abstract Predicting COVID-19 severity is difficult, and the biological pathways involved are not fully understood. To approach this problem, we measured 4701 circulating human protein abundances in two independent cohorts totaling 986 individuals. We then trained prediction models including clinical risk factors to predict 417 subjects tested these a separate cohort of 569 For severe COVID-19, baseline model age sex provided an area under receiver operator curve (AUC) 65% test cohort....
The precise relationship between epigenetic alterations and telomere dysfunction is still an extant question. Previously, we showed that eroded telomeres lead to differentiation instability in murine embryonic stem cells (mESCs) via DNA hypomethylation at pluripotency-factor promoters. Here, uncovered telomerase reverse transcriptase null (Tert-/-) mESCs exhibit genome-wide chromatin accessibility gene expression during differentiation. These changes were accompanied by increase of H3K27me3...
Abstract Proteins detectable in peripheral blood may influence COVID-19 susceptibility or severity. However, understanding which circulating proteins are etiologically involved is difficult because their levels be influenced by itself and also subject to confounding factors. To identify influencing severity we undertook a large-scale two-sample Mendelian randomization (MR) study, since this study design can rapidly scan hundreds of reduces bias due reverse causation confounding. We...
Abstract Introduction Severe COVID-19 leads to important changes in circulating immune-related proteins. To date it has been difficult understand their temporal relationship and identify cytokines that are drivers of severe outcomes underlie differences between sexes. Here, we measured 147 proteins during acute investigate these questions. Methods We protein abundances using the SOMAscan nucleic acid aptamer panel two large independent hospital-based cohorts Canada United States. fit...
Abstract Secretory variant invasive ductal carcinoma is not well described in the literature but defined by its unique histopathology. These tumors stain positive for S100 and are typically triple negative hormonal cancers with an overall good prognosis. There speculation that secretory adults more aggressive a greater likelihood tumor recurrence. We present two case studies of this rare histopathologic diagnosis. First, 76-year-old female recurrent variant, left breast. Second, 68-year-old...
Abstract Predicting COVID-19 severity is difficult, and the biological pathways involved are not fully understood. To approach this problem, we measured 4,701 circulating human protein abundances in two independent cohorts totaling 986 individuals. We then trained prediction models including clinical risk factors to predict adverse outcomes 417 subjects tested these a separate cohort of 569 For severe COVID-19, baseline model age sex provided an area under receiver operator curve (AUC) 65%...
The human brain is a very powerful tool. It allows usto see, remember, understand, and learn. With newtechnologies being discovered every day, scientistsare able to discover how people acquire, process,and store information. New technologies such asmagnetic resonance imaging (MRIs) allow scientistunderstand the reacts particularstimulus or structure can affect person’shealth personality.The nervous system works hand-in-handand coexist in order function everyday life. Thestudy of...
Abstract Background: Pertuzumab, a monoclonal antibody targeting subdomain II of HER2 and blocking dimerization, was approved by the FDA in 2013 as neoadjuvant therapy combination with trastuzumab + chemotherapy for HER2+ locally advanced or early-stage breast cancer patients (pts). TCHP (Docetaxel/Carboplatin/Trastuzumab/Pertuzumab) is popular, non-anthracycline therapy. In TRYPHAENA trial, pathologic complete response (pCR) rate 63.6% 6 cycles (47.5% ER+/PR+ 81.1% ER-/PR- tumors). We...