A5027698049- Developmental Biology and Gene Regulation
- Wnt/β-catenin signaling in development and cancer
- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Acoustic Wave Phenomena Research
National Institute on Deafness and Other Communication Disorders
2019
National Institutes of Health
2019
Hepatocyte growth factor (HGF) is a multifunctional protein that signals through the MET receptor. HGF stimulates cell proliferation, dispersion, neuronal survival, and wound healing. In inner ear, levels of must be fine-tuned for normal hearing. mice, deficiency expression limited to auditory system, or an overexpression HGF, causes neurosensory deafness. humans, noncoding variants in are associated with nonsyndromic deafness DFNB39 . However, mechanism by which these was unknown. Here, we...
Outer hair cell (OHC) stereocilia bundle deflection opens mechanoelectrical transduction channels at the tips of from middle and short rows, while cohesion is maintained owing to presence horizontal top connectors. Here, we used a quantitative noncontact atomic force microscopy method investigate stiffness damping, when stimulated acoustic frequencies nanometer distances bundle. Stereocilia mechanics were determined in stereocilin-deficient mice lacking connectors with detached tectorial...