A5102958088- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Diagnosis and treatment of tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Tuberculosis
- HIV/AIDS Impact and Responses
- Health Systems, Economic Evaluations, Quality of Life
- Clinical Laboratory Practices and Quality Control
- Global Maternal and Child Health
- Animal Diversity and Health Studies
- Computational Drug Discovery Methods
- Iron Metabolism and Disorders
- Burkholderia infections and melioidosis
- Bacterial Identification and Susceptibility Testing
- Hemoglobinopathies and Related Disorders
- Genetics, Bioinformatics, and Biomedical Research
- Antibiotic Use and Resistance
- Urinary Tract Infections Management
- Genomics and Phylogenetic Studies
- Biomedical Text Mining and Ontologies
- Global Public Health Policies and Epidemiology
- Child Nutrition and Water Access
- Parasites and Host Interactions
- Blood donation and transfusion practices
Ethiopian Public Health Institute
2018-2024
Hawassa University
2024
Salale University
2024
Hospital Universitario 12 De Octubre
2020
Addis Ababa University
2020
Emory University
2020
Background Bringing reliable and accurate tuberculosis (TB) diagnosis closer to patients is a key priority for global TB control. Molbio Diagnostics have developed the Truenat point-of-care molecular assays detection of rifampicin (RIF) resistance. Methods We conducted prospective multicentre diagnostic accuracy study at 19 primary healthcare centres seven reference laboratories in Peru, India, Ethiopia Papua New Guinea estimate MTB, MTB Plus MTB-RIF Dx pulmonary using culture phenotypic...
Background Multidrug drug-resistant tuberculosis (MDR-TB) is a major health problem and seriously threatens TB control prevention efforts globally. Ethiopia among the 30th highest burden countries for MDR-TB with 14% prevalence previously treated cases. The focus of this study was on determining drug resistance patterns Mycobacterium suspected cases associated risk factors. Methods A cross-sectional conducted in Addis Ababa from June 2015 to December 2016. Sputum samples socio-demographic...
The diagnoses of active smear negative PTB, remains difficult. As a result, treatment is often carried out empirically relaying on clinical criteria. distribution and magnitude MDR-TB associated factors in the same day diagnosis strategy are not clearly known study area. Therefore, this aimed to determine prevalence TB, risk among presumptive pulmonary tuberculosis patients Addis Ababa, Ethiopia.Analytic cross sectional design was used. A total 418 TB were enrolled from selected health...
Young children cannot easily produce sputum for diagnosis of pulmonary tuberculosis (TB). Alternatively, Mycobacterium complex bacilli can be detected in stool by using the Xpert MTB/RIF (Ultra) assay (Xpert).
Rapid and sensitive Tuberculosis (TB) diagnosis closer to patients is a key global TB control priority. Truenat assays (MTB, MTB Plus, MTB-RIF Dx) are new molecular diagnostic tools for the detection of Rifampicin (RIF)-resistance from sputum samples. The accuracy needed prior implementation in clinical use Ethiopia. This study aimed determine sensitivity specificity assays; compare Xpert MTB/RIF assay.
Abstract Treatment interruption is one of the main risk factors poor treatment outcome and occurrence additional drug resistant tuberculosis. This study a national retrospective cohort with 10 years follow up period in MDR-TB patients Ethiopia. We included 204 who had missed at least for day over course (exposed group) 203 never interrupted (unexposed group). categorized into successful (cured or completed) unsuccessful (lost to up, failed died). described by length time between...
In co-endemic areas, rate of intestinal parasites and tuberculosis (TB) co-infection thought to be high. However, there are limited studies on the epidemiology this in Ethiopia. Therefore, present study aimed generate evidence associated factors among pulmonary patients (PTB) their household contacts Addis Ababa, Unmatched case-control was conducted. Data were collected from 91 PTB (cases) 89 (controls). Socio-demographic characteristics using structured questionnaire. Sputum, stool blood...
Abstract The Mycobacterium tuberculosis complex (MTBC) includes several human- and animal-adapted pathogens. It is thought to have originated in East Africa from a recombinogenic canettii -like ancestral pool. Here, we describe the discovery of clinical strain isolated Ethiopia that shares archetypal phenotypic genomic features M. strains, but represents phylogenetic branch much closer MTBC clade than strains. Analysis traces horizontal gene transfer this isolate previously identified...
Ethiopia is one of the countries with a high tuberculosis (TB) burden, yet little known about spatial distribution Mycobacterium (Mtb) lineages. This study identifies spoligotyping 1735 archived Mtb isolates from National Drug Resistance Survey, collected between November 2011 and June 2013, to investigate population structure distribution. Spoligotype International Types (SITs) lineages were retrieved online databases. The was evaluated using Fisher's exact test logistic regression models....
Objectives Treatment success rate in patients treated for multidrug-resistant tuberculosis (MDR-TB) is low, but predictors of treatment failure and death have been under-reported. Thus, we aimed to determine the national proportion past 10 years factors that predict with MDR-TB Ethiopia. Setting A retrospective cohort study a 10-years follow-up period was conducted 42 treatment-initiating centres Participants total 3395 adult who had final outcome were under TB programme included. Data...
The emergence of drug-resistant tuberculosis (DR-TB) has been a major obstacle to global control programs, especially in developing countries, including Ethiopia. This study investigated drug resistance patterns and associated mutations Mycobacterium Complex (MTBC) isolates from the Amhara, Gambella, Benishangul-Gumuz regions
BackgroundAppropriate technology tests are needed for Mycobacterium tuberculosis drug-susceptibility testing (DST) in resource-constrained settings. This study was performed to evaluate the MDR/XDR-TB Colour Test (a colour platethin-layer agar test; TB-CX) M. DST by directly sputum at University of Gondar Hospital.MethodsSputum samples were each divided into two aliquots. One aliquot mixed with disinfectant and applied TB-CX quadrant petri-plate containing culture medium without isoniazid,...
Background Limited evidence exists on the treatment outcome and factors that are associated with duration from initiation of to death or failure in children drug resistant tuberculosis (DR-TB). Thus, we aimed determine proportion enrollment, status treated for DR-TB Ethiopia. Methods We conducted a retrospective cohort study younger than 15 years old who were February 2009 2019 collected data socio-demographic clinical characteristics charts, registration books laboratory result reports 155...
Introduction The quality of tuberculosis laboratory services in health facilities is a mandatory component detecting active pulmonary TB cases and treatment follow-up. However, ensuring the test results concern. This study aimed to assess assurance practices diagnostic Ethiopia. Materials methods A cross-sectional was conducted from October 2018 March 2019 at nine governmental TB-culture laboratories 34 randomly selected GeneXpert® MTB/RIF (Xpert® MTB/RIF) testing Participating were...
There is limited information on the performance of Xpert
Aims & Objectives: Children with acute critical illness in low- and middle-income countries (LMICs) are often managed hospitals different capacities for providing care. Elements that contribute to care capacity can include infrastructure, personnel, resources, processes, education training. This work outlines the development of a pediatric Critical CAre Resource Evaluation (CritCARE) tool which across resource-variable settings use objectively assess their baseline identify opportunities...
Background Brucellosis is a neglected zoonotic disease often contracted through contact with animals and consumption of unpasteurized dairy products. Despite being the most common cause non-malarial acute febrile illness brucellosis misdiagnosed in healthcare setups. The global incidence Brucella infection reported to be over 2 million cases annually. In Ethiopia, there are varying reports on prevalence brucellosis, just few researches have been undertaken among patients. Therefore, this...
The Objective of this review was to see the ten year EQA performance trend from 2005 till 2014 at Ethiopian national tuberculosis Reference laboratory. finding shows that 81.3% and 11.2%of participation were ZN-AFB phenotypic DST respectively. remaining for LPA-PT with proportion 4.6% 2.3% GeneXpert. Most EQA-PT NTRL scored above 80% 90% Phenotypic 1st 2nd line Anti-TB drug. efficiency reveal most tested drugs achieved acceptable good agreement result compared SRLN laboratory test record...
Abstract Background In 2018, an estimated 10 million people developed tuberculosis, of whom more than 1.45 died. The microscopy method used in most tuberculosis high burden and resource-limited countries is less accurate for diagnosing the disease. Thus, evaluation available diagnostic modalities country crucial, this study aimed to evaluate performance Abbott real-time PCR as a technique Ethiopia. Methods A cross-sectional survey was conducted using sputum specimens collected from 150...