A5079616920- COVID-19 Impact on Reproduction
- Vaccine Coverage and Hesitancy
- Reproductive System and Pregnancy
- Pregnancy and Medication Impact
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Pregnancy and preeclampsia studies
University of Washington
2022-2024
In pregnant people with prior SARS-CoV-2 infection, hybrid immunity (infection plus vaccination) before delivery provided more durable maternally-derived antibody responses than infection or vaccination alone in infants through 6 months of age.
Abstract Background Hybrid immunity (infection plus vaccination) may increase maternally derived SARS-CoV-2 antibody responses and durability versus infection alone. Methods Prospective cohort of pregnant participants with prior (anti-nucleocapsid IgG, RT-PCR, or antigen positive) their infants had blood collected in pregnancy, at delivery/birth, postpartum tested for anti-spike (anti-S) IgG neutralizing antibodies (neutAb). Results Among 107 enrollment, 40% were unvaccinated 60% vaccinated...
Background: Antenatal care provides unique opportunities to assess severe acute respiratory syndrome coronavirus 2 seroprevalence and antibody response duration after natural infection detected during pregnancy; transplacental transfer may inform peripartum neonatal protection. We estimated durability of antibodies from (anti-nucleocapsid immunoglobulin G) among pregnant people, evaluated efficiency. Objective design: conducted a cross-sectional study measure seroprevalence, prospective...
Abstract Importance Antenatal care provides unique opportunities to assess SARS-CoV-2 seroprevalence and antibody response duration after natural infection detected during pregnancy; transplacental transfer may inform peripartum neonatal protection. Objective Estimate durability of antibodies from (anti-nucleocapsid (anti-N) IgG) among pregnant people, evaluate efficiency. Design Seroprevalence study: cross-sectional screening people December 9, 2020-June 19, 2021. Cohort Pregnant screened...
Abstract Background Immunity from natural infection and vaccination (hybrid) may provide more durable SARS-CoV-2 antibody responses; whether this increases durability of maternally-derived responses in infants is unknown. Methods Participants with prior pregnancy (anti-nucleocapsid [anti-N] IgG+ on enrollment or RT-PCR+ antigen+) were enrolled between January 2021-August 2022. Blood samples collected pregnancy, delivery/birth, 0-< 3 3-6 months postpartum tested for anti-S+ IgG by...
Abstract Background Natural SARS-CoV-2 infection results in anti-nucleocapsid (N) and anti-spike (S) antibody (Ab) development. Anti-S Ab response (conferred by and/or vaccination) is more closely associated with protection. We evaluated anti-N/S responses vaccinated (> 1 dose) unvaccinated pregnant people prior SAR-CoV-2 infection. Methods During January 2021-March 2022, we enrolled participants identified pregnancy (26 via anti-N IgG+; 52 RT-PCR+). Baseline, 1, 2, 3, 6, 12 months,...