A5039697358- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Bone health and treatments
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Peptidase Inhibition and Analysis
- Economic and Financial Impacts of Cancer
- Neuroblastoma Research and Treatments
- Multiple and Secondary Primary Cancers
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Medical Imaging and Pathology Studies
- Lung Cancer Research Studies
- Bone health and osteoporosis research
- Parathyroid Disorders and Treatments
- Bone Metabolism and Diseases
- Esophageal Cancer Research and Treatment
- Cancer Mechanisms and Therapy
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Cancer, Lipids, and Metabolism
- Estrogen and related hormone effects
- Histiocytic Disorders and Treatments
Mayo Clinic
2021-2025
Mayo Clinic in Arizona
2020-2024
Case Western Reserve University
2023
WinnMed
2021-2022
University of South Carolina
2017-2021
Augusta University
2021
Institute of Medical Sciences
2021
The University of Texas at Dallas
2021
Brown University
2021
University of Arizona
2021
Abstract Background Regulatory agencies have concluded that sodium glucose cotransporter 2 (SGLT2) inhibitors lead to ketoacidosis, but published literature on this point remains controversial. Methods We searched the FDA Adverse Event Reporting System (FAERS) for reports of acidosis in patients treated with canagliflozin, dapagliflozin, or empagliflozin (from date each drug's approval until May 15, 2015). compared number SGLT2 inhibitor‐related most commonly used DPP4 inhibitors:...
Immune checkpoint inhibitors, including anti-programmed cell death protein 1 (PD-1), ligand (PD-L1), and anti-cytotoxic T-lymphocyte antigen 4 (anti-CTLA4) monoclonal antibodies, have been widely used in cancer treatment. They are known to cause immune-related adverse events (irAEs), which resemble autoimmune diseases. Anterior pituitary hypophysitis with secondary hypopituitarism is a frequently reported irAE, especially patients receiving anti-CTLA4 In contrast, posterior involvement, such...
Identifying the projected incidence of hepatobiliary cancers and recognizing patient cohorts at increased risk can help develop targeted interventions resource allocation. The expected subtypes in different age groups, races, genders remains unknown. Historical epidemiological data from Surveillance, Epidemiology, End Results (SEER) database was used to project future malignancies United States identify trends by age, race, gender. Patients ≥18 years diagnosed with a malignancy between 2001...
Adrenocortical carcinoma (ACC) is rare; knowledge about prognostic factors and survival outcomes limited.To describe predictors of overall (OS) outcomes.Retrospective analysis data from the National Cancer Database (NCDB) 2004 to 2015 on 3185 patients with pathologically confirmed ACC.Baseline description, outcomes, were evaluated in ACC.Median age at ACC diagnosis was 55 (range: 18 90) years; did not differ significantly by sex or stage disease diagnosis. On multivariate analysis,...
Clinicopathological features and the outcomes of patients with fibrolamellar hepatocellular carcinoma (FLHCC) are not clearly defined.Data were collected by retrospective chart review on 42 FLHCC treated between 1990 2017 at Mayo Clinic.Of (median age diagnosis 22 years), 10 (23.8%) had stage I disease 32 (76.2%) II to IVB disease. All 21 II-IVB underwent resection presentation. In patient group, 6 experienced recurrence a median time 30.5 months 5-year overall survival (OS) 86%. Patients...
Pancreatic neuroendocrine neoplasm (panNEN) is a rare malignancy and the second most common type of pancreatic cancer, after ductal adenocarcinoma (PDAC), but its etiology poorly understood. We investigated whether risk factors panNEN are concordant with those known for PDAC. performed largest case-control study to date on panNENs comprising 927 sporadic nonfunctional cases 1807 frequency-matched controls using data from Mayo Clinic Biospecimen Resource Pancreas Research. assessed...
African Americans (AAs) are at a higher risk for developing type 2 diabetes compared with non-Hispanic whites (NHWs). The causal role of β-cell glucose sensitivity (β-GS) and insulin clearance in hyperinsulinemia AA adults is unclear.Using cross-sectional study design, we function nondiabetic AAs (n = 36) NHWs 47) after mixed meal test (MMT).Insulin secretion rate, sensitivity, rate during MMT were derived from mathematical model. Levels insulin-degrading enzyme (IDE) carcinoembryonic...
ABSTRACT Scoliosis is a complication of fibrous dysplasia/McCune-Albright syndrome (FD/MAS); however, risk factors and long-term outcomes are unknown. Bisphosphonates commonly used; it unknown whether their use decrease the progressive scoliosis. Clinical data from National Institutes Health (NIH) cohort study was reviewed. Cobb angles were measured, variables associated with scoliosis progression identified. Of 138 subjects available radiographs, 84 (61%) had scoliosis, including 55 (65%)...