A5045560318- Microfluidic and Bio-sensing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrowetting and Microfluidic Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Bacteriophages and microbial interactions
- 3D Printing in Biomedical Research
- Slime Mold and Myxomycetes Research
- Biocrusts and Microbial Ecology
- Viral Infectious Diseases and Gene Expression in Insects
Technische Universität Braunschweig
2019-2025
Fraunhofer Institute for Microengineering and Microsystems
2019
ABSTRACT To increase their throughput, reduce laboratory work and improve reproducibility, automation of bioprocesses is gaining in importance nowadays. This applies particular to microbioreactors (MBRs), which can be easily integrated highly parallelized automated platforms and, therefore, applied for screenings, cell‐based assays, bioprocess development. One promising pharmaceutical application MBRs the performance phage sensitivity tests called phagograms therapy. However, there no...
Due to the overuse of antibiotics, number multidrug-resistant pathogen bacteria is rising in recent years posing a serious threat human health. One promising alternative for treatment application phage therapy using highly selective bacteriophages. Because their selectivity, individual screens called phagograms each patient are required select phages from library. Phagograms mostly performed via bacterial cultivation on double layer agar plates and addition causing lysis. However, these...
In this work, manipulating width and equilibrium position of fluorescent microparticles in spiral microchannel fractionation devices by embedding microchambers along the last turn a is reported.
Microbioreactors are gaining increased interest in biopharmaceutical research. Due to their decreasing size, the parallelization of multiple reactors allows for simultaneous experiments. This enables generation high amounts valuable data with minimal consumption precious pharmaceutical substances. However, bioreactors all scales, fast mixing represents a crucial condition. Efficient transportation nutrients cells ensures good growing conditions, homogeneous environmental conditions...
For high-throughput cell culture and associated analytics, droplet-based cultivation systems open up the opportunities for parallelization rapid data generation. In contrast to microfluidics with continuous flow, sessile droplet approaches enhance flexibility fluid manipulation less operational effort. Generating biologically favorable conditions promoting growth in a droplet, however, is particularly challenging due mass transfer limitations, which has be solved by implementing an effective...
Microbioreactors (MBRs) with a volume below 1 mL are promising alternatives to established cultivation platforms such as shake flasks, lab-scale bioreactors and microtiter plates. Their main advantages simple automatization parallelization the saving of expensive media components test substances. These particularly pronounced in small-scale MBRs 10 µL. However, most described lacking process information from integrated sensors due limited space sensor technology. Therefore, novel...
Microbioreactors increase information output in biopharmaceutical screening applications because they can be operated parallel without consuming large quantities of the pharmaceutical formulations being tested. A capillary wave microbioreactor (cwMBR) has recently been reported, allowing cost-efficient parallelization an array that activated for mixing as a whole. Although impedance spectroscopy directly distinguish between dead and viable cells, monitoring cells suspension within...
Filamentous microorganisms exhibit a complex macro-morphology constituted of branched and cross-linked hyphae. Fully resolved mechanical models such mycelial compounds rely heavily on accurate input data for properties individual Due to their irregular shape high adaptability environmental factors, the measurement these intrinsic remains challenging. To overcome previous shortcomings microfluidic bending tests, novel system precise stiffness fungal hyphae is presented in this study....
For high-throughput cell culture and associated analytics, droplet-based cultivation systems open up the opportunities for parallelization rapid data generation. In contrast to microfluidics with continuous flow, sessile droplet approaches enhance flexibility fluid manipulation usually less operational effort. Generating biologically favorable conditions promoting growth in a droplet, however, is particularly challenging due mass transfer limitations, which has be solved by implementing an...