A5103273179- Innovative Microfluidic and Catalytic Techniques Innovation
- 3D Printing in Biomedical Research
- Microfluidic and Capillary Electrophoresis Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Microfluidic and Bio-sensing Technologies
- Genetic and phenotypic traits in livestock
- Reproductive Biology and Fertility
- Milk Quality and Mastitis in Dairy Cows
- Electrohydrodynamics and Fluid Dynamics
- Electrowetting and Microfluidic Technologies
- Fluid Dynamics and Mixing
- Protein purification and stability
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Control Systems in Engineering
- Fluid Dynamics and Heat Transfer
- Microbial Metabolic Engineering and Bioproduction
- Vehicle Dynamics and Control Systems
- Microbial Metabolism and Applications
- Enzyme Catalysis and Immobilization
- Gas Sensing Nanomaterials and Sensors
- Advanced Chemical Sensor Technologies
- Vibrio bacteria research studies
- Electric and Hybrid Vehicle Technologies
- Aquaculture Nutrition and Growth
Technische Universität Braunschweig
2011-2025
John Wiley & Sons (United States)
2018
Hudson Institute
2018
A diffusion-based microreactor system operated with a reaction volume of 8 μL is presented and characterized to intensify the process understanding in microscale cultivations. Its potential as screening tool for biological processes evaluated. The advantage designed microbioreactor use continuous cultivation mode by integrating online measurement technique dissolved oxygen (DO) optical density (OD). further broaden application systems. bioreactor geometry was chosen achieve homogeneous flow...
A new disposable, multiphase, microbioreactor (MBR; with a working volume of 550 μl) equipped online sensors is presented for biotechnological screening research purposes owing to its high-throughput potential. Its design and fabrication, sensor integration, operation are described. During aerobic cultivation, sufficient oxygen supply the most important factor that influences growth product formation. The MBR microbubble column bioreactor (μBC), was realized by active pneumatic bubble...
ABSTRACT To increase their throughput, reduce laboratory work and improve reproducibility, automation of bioprocesses is gaining in importance nowadays. This applies particular to microbioreactors (MBRs), which can be easily integrated highly parallelized automated platforms and, therefore, applied for screenings, cell‐based assays, bioprocess development. One promising pharmaceutical application MBRs the performance phage sensitivity tests called phagograms therapy. However, there no...
ABSTRACT This paper presents the applicability of a microtechnologically fabricated microbubble column as screening tool for submerged aerobic cultivation. Bubbles in range few hundred micrometers diameter were generated at bottom an upright‐positioned microdevice. The rising bubbles induced circulation liquid and thus enhanced mixing by reducing diffusion distances preventing cells from sedimentation. Two differently sized nozzles (21 × 40 µm 2 53 cross‐section) tested. gas flow rates...
With the technological advances in 3D printing technology, which are associated with ever-increasing resolution, additive manufacturing is now increasingly being used for rapid of complex devices including microsystems development laboratory applications. Personalized experimental or entire bioreactors high complexity can be manufactured within few hours from start to finish. This study presents a customized 3D-printed micro bubble column reactor (3D-µBCR), cultivation microorganisms (e.g.,...
In this work a disposable, parallel microbioreactor (MBR) suitable for screening in batch or continuous mode is presented. The reactor consists of five microchambers made poly(dimethylsiloxane) bonded to glass substrate. A grid structure engraved on each chamber, allowing subsequent morphology imaging. Measurements are recorded over the entire cultivation period with constant parameters, namely, position and focus z-axis. microdevice may be used either parallel, uni- multiparametric...
Abstract Micro‐bioreactors (MBRs) have become an indispensable part for modern bioprocess development enabling automated experiments in parallel while reducing material cost. Novel developments aim to further intensify the advantages as dimensions are being reduced. However, one factor hindering scale‐down of cultivation systems is provide adequate mixing and mass transfer. Here, vertical oscillation demonstrated effective method MBRs with a reaction volume 20 μL providing Electrodynamic...
For high-throughput cell culture and associated analytics, droplet-based cultivation systems open up the opportunities for parallelization rapid data generation. In contrast to microfluidics with continuous flow, sessile droplet approaches enhance flexibility fluid manipulation less operational effort. Generating biologically favorable conditions promoting growth in a droplet, however, is particularly challenging due mass transfer limitations, which has be solved by implementing an effective...
Abstract A novel bioreactor simulating human colonic conditions for in vitro cultivation of intestinal microbiota is presented. The PE ristaltic mixed T ubular bio R eactor (PETR) modular designed and periodically kneaded to simulate peristalsis. reactor introduced, characterized from a bioprocess engineer's perspective discussed its ability mimic colon conditions. PETR provides physiological temperature appropriate anaerobic conditions, simulates peristalsis, has mean residence time 32.8 ±...
Abstract Im letzten Jahrzehnt hat die Mikrobioreaktor (MBR)‐Technologie rasche Fortschritte in der biotechnologischen Prozessentwicklung und Untersuchung biologischer Systeme von industriellen Biotechnologie bis hin zur Pharmabioverfahrenstechnik erzielt. Zahlreiche MBR‐Systeme werden Literatur vorgestellt, als automatisierte, parallele Bioreaktoren für den Laboreinsatz entwickelt wurden, um einen sinnvollen Scale‐up/‐down konventioneller biotechnologischer Pilotanwendungen industrieller...
Microbioreactors (MBRs) with a volume below 1 mL are promising alternatives to established cultivation platforms such as shake flasks, lab-scale bioreactors and microtiter plates. Their main advantages simple automatization parallelization the saving of expensive media components test substances. These particularly pronounced in small-scale MBRs 10 µL. However, most described lacking process information from integrated sensors due limited space sensor technology. Therefore, novel...
US$18141 (US and Rest of World), € 11707 (Europe), £ 9260 (UK