A5017599949- Electrochemical sensors and biosensors
- Analytical Chemistry and Sensors
- Microfluidic and Capillary Electrophoresis Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- 3D Printing in Biomedical Research
- Diet and metabolism studies
- Electrochemical Analysis and Applications
- Advanced biosensing and bioanalysis techniques
- Cardiac Ischemia and Reperfusion
- Organ Transplantation Techniques and Outcomes
- Advanced Biosensing Techniques and Applications
- SARS-CoV-2 detection and testing
- Conducting polymers and applications
- Biosensors and Analytical Detection
- Viral Infectious Diseases and Gene Expression in Insects
- Clinical Nutrition and Gastroenterology
- Mass Spectrometry Techniques and Applications
- Stress Responses and Cortisol
- Cervical Cancer and HPV Research
- Reproductive tract infections research
- Neuroscience and Neural Engineering
- Hydrogen's biological and therapeutic effects
- Adrenal Hormones and Disorders
- Reproductive System and Pregnancy
- Microfluidic and Bio-sensing Technologies
Harvard University
2020-2024
Harvard University Press
2024
Inspire
2023-2024
Kajaani University of Applied Sciences
2010-2021
University of Oulu
2010-2020
University of Rome Tor Vergata
2018
John Wiley & Sons (United States)
2018
Hudson Institute
2018
Cranfield University
2001
In vitro models of human organs must accurately reconstitute oxygen concentrations and gradients that are observed in vivo to mimic gene expression, metabolism, host-microbiome interactions. Here we describe a simple strategy achieve physiologically relevant tension two-channel small intestine-on-a-chip (Intestine Chip) lined with primary duodenal epithelium intestinal microvascular endothelium parallel channels separated by porous membrane while both perfused oxygenated medium. This was...
Abstract Modulation of the cervix by steroid hormones and commensal microbiome play a central role in health female reproductive tract. Here we describe organ-on-a-chip (Organ Chip) models that recreate human cervical epithelial-stromal interface with functional epithelial barrier production mucus biochemical hormone-responsive properties similar to living cervix. When Cervix Chips are populated optimal healthy versus dysbiotic microbial communities (dominated Lactobacillus crispatus...
Despite remarkable advances in Organ-on-a-chip (Organ Chip) microfluidic culture technology, recreating tissue-relevant physiological conditions, such as the region-specific oxygen concentrations, remains a formidable technical challenge, and analysis of tissue functions is commonly carried out using one analytical technique at time. Here, we describe two-channel Organ Chip devices fabricated from polydimethylsiloxane gas impermeable polycarbonate materials that are integrated with multiple...
A new disposable, multiphase, microbioreactor (MBR; with a working volume of 550 μl) equipped online sensors is presented for biotechnological screening research purposes owing to its high-throughput potential. Its design and fabrication, sensor integration, operation are described. During aerobic cultivation, sufficient oxygen supply the most important factor that influences growth product formation. The MBR microbubble column bioreactor (μBC), was realized by active pneumatic bubble...
Abstract A novel MB‐SWNT‐sol‐gel nanocomposite material was prepared by the sol‐gel process incorporating a redox mediator and carbon nanotubes. The electrocatalytic properties of nanomaterial based sensor toward NADH oxidation were studied electrochemical measurements. Significant enhancement current is obtained at electrodes modified in comparison with analogous black and/or graphite composite electrode. usefulness as matrix for immobilizing enzymes also demonstrated. Analytical parameters...
Bioprocessing is of crucial importance in pharmaceutical, biofuel, food and other industries. Miniaturization bioprocesses into microbioreactors allows multiplexing experiments as well reduction reagent consumption labour-intensity. A part the research within biochemical analysis product, byproduct substrate concentrations that currently heavily relies on large analytical equipment. Biosensors are a promising tool, however, integration microbioreactor associated with challenges ensuring...
The coronavirus disease 2019 (COVID-19) pandemic has brought about the unprecedented expansion of highly sensitive molecular diagnostics as a primary infection control strategy. At same time, many laboratories have shifted focus to severe acute respiratory syndrome 2 (SARS-CoV-2) research and diagnostic development, leading large-scale production SARS-CoV-2 nucleic acids that can interfere with these tests. We identified multiple instances, in independent laboratories, which generated...
A novel flow injection microfluidic immunoassay system for continuous monitoring of saxitoxin, a lethal biotoxin, in seawater samples is presented this article. The consists preimmobilized G protein immunoaffinity column connected line with lab-on-chip setup. detection saxitoxin was carried out two steps: an offline incubation step (competition reaction) performed between the analyte interest (saxitoxin or Ag, as standard sample) and tracer (an enzyme-conjugated antigen Ag*) toward specific...
ABSTRACT Modulation of mucus production by the human endo– and ecto-cervical epithelium steroid hormones associated interactions with commensal microbiome play a central role in physiology pathophysiology female reproductive tract. However, most our knowledge about these is based on results from animal studies or vitro models that fail to faithfully mimic mucosal environment cervix. Here we describe microfluidic organ-on-a-chip (Organ Chip) cervical mucosa recreate epithelial-stromal...
Drugs that induce reversible slowing of metabolic and physiological processes would have great value for organ preservation, especially organs with high susceptibility to hypoxia-reperfusion injury, such as the heart. Using whole-organism screening metabolism, mobility, development in Xenopus, we identified an existing drug, SNC80, rapidly reversibly slows biochemical activities while preserving cell tissue viability. Although SNC80 was developed a delta opioid receptor activator, discovered...