A5076982848- Drug Solubulity and Delivery Systems
- Pharmacological Effects of Natural Compounds
- Chemical Synthesis and Analysis
- Phytochemistry and biological activity of medicinal plants
- Catalytic Cross-Coupling Reactions
- Crystallization and Solubility Studies
- Advanced Drug Delivery Systems
- Chromatography in Natural Products
- Ginseng Biological Effects and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Analytical Methods in Pharmaceuticals
- Synthetic Organic Chemistry Methods
- Adsorption, diffusion, and thermodynamic properties of materials
- Advanced Scientific Research Methods
- Phytochemistry and Biological Activities
- Phosphorus compounds and reactions
- Rock Mechanics and Modeling
- Axial and Atropisomeric Chirality Synthesis
- Advancements in Transdermal Drug Delivery
- Liver Disease Diagnosis and Treatment
- Phytochemistry and biological activities of Ficus species
- Catalytic C–H Functionalization Methods
- Protein Interaction Studies and Fluorescence Analysis
- Fatigue and fracture mechanics
- Hibiscus Plant Research Studies
Zhejiang University of Technology
2013-2025
Tongji University
2022
State Key Laboratory of Silicon Materials
2021
Zhejiang University
2009-2021
More and more saffron has been cultivated in China because of the increasing demand, but no paper studied influence drying methods on quality Chinese saffron. In this paper, three different dehydration treatments applied actual production were evaluated: with electric oven, vacuum microwave. We determined that highest will be obtained when fresh is treated at higher temperatures (no than 70°C) for a long time by oven drying. microwave drying, lower power longer benefit addition, method...
Objective To enhance solubility and bioavailability of glimepiride (GM), an inclusion compound glimepiride/hydroxypropyl-β-cyclodextrin (GM/HP-β-CD) was prepared using mechanical ball milling.
An efficient mechanically activated solvent‐free synthesis of ( E )‐stilbene derivatives by high‐speed ball milling is described. This method has notable advantages in terms good yield, short reaction time and high selectivity. Copyright © 2012 John Wiley & Sons, Ltd.
Azilsartan (AZL) is an angiotensin II receptor antagonist, which mainly used for the treatment of hypertension. AZL has advantages high selectivity, hypotensive effect, protection cardiovascular and cerebrovascular diseases. In order to improve water solubility its bioavailability, -nicotinamide (NA) cocrystal was prepared by mechanical ball milling, effect milling conditions on preparation were studied. AZL-NA identified characterized powder X-ray diffraction, differential scanning...
Solvent-free coupling reactions of arylboronic acids with various amines were presented under ball milling conditions, achieving the aromatic amine products yields ranging from moderate to good. This type mechano-chemistry exhibited advantages solvent-free property, high efficiency, simple work-up procedure and eco-friendliness.
The amorphous solid dispersions of telmisartan salts were prepared by cogrinding, in presence alkalizers and polyvinylpyrrolidone (PVPk30). Five this study MgO, Na2CO3, K2CO3, NaHCO3 meglumine. In soft mode using a roll mill, the drug could not form salt with MgO or NaHCO3, whereas partial had been transformed into carbonates Under organic base meglumine was easier to react than other two carbonates. For getting good dissolution performance, be completely. A high intensity oscillating mill...
An efficient and solvent-free procedure was developed to improve the solubility bioavailability of poorly water-soluble drug puerarin by mechanochemical technology. The stable inclusion complex 2-hydroxypropyl-β-cyclodextrin (HPCD) prepared a ball mill under following conditions: equimolar ratio HPCD; rotational speed 250 rpm; milling time 90 min; steel balls 22 mm diameter. solid characterized scanning electron microscopy (SEM), differential calorimetry (DSC), powder X-ray diffractometry...
Pazopanib (PZ) is a multikinase inhibitor, which mainly used in the treatment of soft tissue sarcoma and advanced renal cancer. However, because its water insolubility, oral bioavailability poor. At same time, photo lability high dose administration lead to severe hepatotoxicity, limited clinical application. In this paper, novel pazopanib-fumarate disodium glycyrrhizinate nanocrystalline micelles are successfully prepared by liquid-assisted ball milling. The cocrystals micelle structures...
Abstract Molecularly imprinted membranes (MIMs) for selective separation of magnolol were prepared by thermal polymerization using as the template, ethylene glycol dimethacrylate (EGDMA) cross‐linker, 2,2‐azobisisobutyronitrile (AIBN) initiator, organic solvent porogen, methacrylamide (MAM) and acrylic acid (AA) functional monomers cellulose acetate agglutinant. Commercial filter paper was used supporting material. The effects different porogens ratio on binding recognition capacity MIMs...
Enantioselective synthesis of α-amino esters have been achieved through the Petasis borono-Mannich multicomponent reaction using ( R)-BINOL-derived catalysts with stable heteroaryl and alkenyl trifluoroborate salts under mild conditions. The provides direct access to optically active moderate good yields enantioselectivities.
The inclusion complex was prepared by co-grinding α-lipoic acid with hydroxypropyl-β-cyclodextrin and alkalizer to enhance the solubility stability of acid. Lipoic chosen as a model drug because its poor pH-dependent aqueous solubility. Sodium carbonate sodium bicarbonate were pH regulators. Furthermore, study investigated proportion alkalizer, Although micronization has little effect on drug, formation amorphous form an important complexes. X-ray powder diffractometry differential scanning...
A series of phenylhydrazone derivatives was synthesized from arenediazonium tetrafluoroborates and active methylene compounds under high-speed ball milling. The reaction occurred in the absence solvent products were obtained good yield within short times (no more than 30 min). Keywords: Ball milling, solid-state synthesis, phenylhydrazones, tetrafluoroborates, compounds.
Mechanochemical-assisted extraction (MCAE) of hesperidin from Pericarpium Citri Reticulatae was investigated in AGO-2 high intensity planetary activator. In order to optimize efficiency, six variables (different kinds reagents, Na2CO3 content, grinding time, temperature, liquid/solid ratio) were varied. Results showed that the optimum MCAE conditions determined as: content 30.0% (w/w), time 20 min, temperature °C, 10 ratio 80:1 mL/g. Meanwhile, enhancement solubility measured. Fourier...