A5077522339- Cancer Cells and Metastasis
- Cellular Mechanics and Interactions
- Radiation Dose and Imaging
- Radioactivity and Radon Measurements
- Microtubule and mitosis dynamics
- Radioactive contamination and transfer
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Fibroblast Growth Factor Research
- Cancer-related Molecular Pathways
- Tissue Engineering and Regenerative Medicine
- Biochemical and Molecular Research
- Plant nutrient uptake and metabolism
- Thyroid Cancer Diagnosis and Treatment
- Caveolin-1 and cellular processes
- Protease and Inhibitor Mechanisms
- Protein Structure and Dynamics
- Mesenchymal stem cell research
- Plant Molecular Biology Research
- RNA and protein synthesis mechanisms
- Telomeres, Telomerase, and Senescence
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
Brown University
2021-2023
Complejo Hospitalario de Pontevedra
2012-2015
Cancer Genetics (United States)
2015
The Ohio State University
2015
Metastatic progression of epithelial ovarian cancer (EOC) involves the partial epithelial-to-mesenchymal transition (EMT) cells in primary tumor and dissemination into peritoneal fluid. In part to high degree heterogeneity EOC cells, identification EMT highly response differences matrix mechanics, growth factor signaling, tissue hypoxia is very difficult. We analyzed different degrees by tracking changes cell nuclear morphology, along with organization cytoskeletal proteins. our analysis, we...
Abstract More than 75% of epithelial ovarian cancer (EOC) patients experience disease recurrence after initial treatment, highlighting our incomplete understanding how chemoresistant populations evolve over the course EOC progression post chemotherapy treatment. Here, we show two paclitaxel (PTX) treatment methods- a single high dose and weekly metronomic for four weeks, generate unique populations. Using mechanically relevant alginate microspheres combination transcript profiling...
Abstract The essential bacterial division protein in Escherichia coli , FtsZ, assembles into the FtsZ‐ring at midcell and recruits other proteins to site promote septation. A region of FtsZ amino acid sequence that links conserved polymerization domain a C‐terminal interaction was predicted be intrinsically disordered has been implicated modulating spacing architectural arrangements filaments. While majority cell directly bind engage either or site, ClpX, recognition unfolding component...
In Arabidopsis seedlings, inhibition of aspartate transcarbamoylase (ATC) and de novo pyrimidine synthesis resulted in starvation developmental arrest a few days after germination. Synthesis nucleotides by salvaging exogenous uridine (Urd) restored normal seedling growth development. We used this experimental system transcriptional profiling to investigate genome-wide responses changes availability. Gene expression at different times Urd supplementation pyrimidine-starved seedlings were...
More than 70% of all patients diagnosed with epithelial ovarian cancer (EOC) succumb to their disease making EOC the most lethal gynecological cancer. The astonishingly high mortality rate can be explained largely by fact that 75% cases are at advanced or metastatic stages thus highlighting urgency better understand what cues in primary tumor microenvironment (TME) promote metastasis. Up 80% these experience reoccurrence demonstrating addition early events progression, how populations...