A5037472644- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- Otitis Media and Relapsing Polychondritis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cystic Fibrosis Research Advances
- Veterinary Equine Medical Research
- Autoimmune Bullous Skin Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Respiratory Support and Mechanisms
- Sports Performance and Training
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mechanical Circulatory Support Devices
- Urticaria and Related Conditions
- Muscle metabolism and nutrition
- Systemic Lupus Erythematosus Research
- Breastfeeding Practices and Influences
- Radiopharmaceutical Chemistry and Applications
- Cell Adhesion Molecules Research
- Inhalation and Respiratory Drug Delivery
- Cancer Genomics and Diagnostics
- Renal function and acid-base balance
- Prenatal Screening and Diagnostics
- Radiation Effects and Dosimetry
- Neonatal Respiratory Health Research
- Biosensors and Analytical Detection
University of Birmingham
2017-2024
Queen Elizabeth Hospital Birmingham
2017-2024
University of Cambridge
2024
ENT and Allergy
2022
University of Hull
2022
Piedmont International University
2022
Harper College
2022
Harper University Hospital
2022
Centre for Inflammation Research
2021
Heart of England NHS Foundation Trust
2016
Retrospective lineage reconstruction of humans predicts that dramatic clonal imbalances in the body can be traced to 2-cell stage embryo. However, whether and how such asymmetries arise embryo is unclear. Here, we performed prospective tracing human embryos using live imaging, non-invasive cell labeling, computational predictions determine contribution each blastomere epiblast (body), hypoblast (yolk sac), trophectoderm (placenta). We show majority cells originate from only one observe three...
Key Points Fifty-five percent of patients achieve long-term remission after rituximab treatment. This is influenced by maintenance therapy with rituximab. A substantial reduction annualized relapse rate and concomitant immunosuppression was observed Background Long-term outcomes rituximab-treated adult podocytopathies (either minimal change disease or FSGS) are largely unknown. Methods retrospective study at 30 nephrology departments from 15 countries worldwide included adults primary a...
Summary A standardised incremental exercise test was performed by 9 racehorses with idiopathic laryngeal hemiplegia (ILH), 1 horse maxillary sinus cysts, epiglottic entrapment, a lesion on the vocal folds, and pharyngitis. Two of horses ILH were retested after laryngoplasty ventriculectomy. The findings compared those from 20 normal racehorses. Heart rate, plasma lactate concentration, arterial blood gases, stride frequency, oxygen uptake (V̇o 2 ) carbon dioxide production assessed during...
Corticosteroids are the basis of treatment for nephrotic syndrome due to minimal change disease (MCD), but 25% patients have frequently relapsing (FRNS) and 30% become steroid dependent. Prolonged use conventional immunosuppressants causes significant toxicity. Rituximab (RTX) is now included in guidelines childhood MCD. Evidence adult MCD limited. We describe a single-centre experience RTX MCD.Outcomes all treated with FRNS between 2008 2015 were retrospectively analysed.Thirteen received...
Summary Acclimation to treadmill exercise and a respiratory gas collection mask were studied in 3 groups of Thoroughbred or Standardbred horses. Heart rate plasma lactate concentration measured at rest the completion each speed increment during series acclimating runs 4, 6 8 m/s on inclined 10% slope. No significant differences found heart between for any groups, except reduction 1 2 4 group 19 racehorses that received ( Group ). values significantly higher subsequent test 12 prior Plasma...
Summary We examined 106 Thoroughbred (TB) and 51 Standardbred (SB) racehorses that were presented because of poor performance. All horses in training had raced within 2 weeks presentation. Horses acclimatised (2–4 runs) tested on a treadmill set at 10% slope. The exercise test consisted 3 min 4 m/s, 6 then 1 steps 8, 10, 11, 12 13 m/s or until the horse could not maintain pace with treadmill. At end each speed, arterial blood expired gas samples collected heart rate recorded. Measurements...
Abstract Background Venous thromboembolism (VTE) is a common complication in patients with anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) and confers significant morbidity mortality. Both acute past cytomegalovirus (CMV) infection have been identified as risk factors for VTE immunocompetent immunosuppressed individuals. Here, we examine whether exposure to CMV factor amongst AAV. Methods We retrospectively analysed outcomes of new diagnosis AAV from UK cohort. All...
Abstract Background and Aims Avacopan was approved in the UK for severe ANCA associated vasculitis (AAV) December 2022. The ADVOCATE trial found differential effect of avacopan on kidney function greatest patients with lowest estimated glomerular filtration rate (eGFR), at highest risk progression to end stage disease (ESKD). Patients an eGFR <15 ml/min/1.73 m2, pulmonary haemorrhage requiring invasive ventilation, under 12 months prognosis, use plasma exchange dual therapy...
Established indications for non-invasive ventilation (NIV) include acute or acute-on-chronic type 2 respiratory failure associated with acidosis. It is commonly assumed that this acidosis a secondary phenomenon which follows the development of hypercapnia. This case series describes four patients acidotic hypercapnia (type to metabolic acidosis) demonstrated through serial arterial blood gases who were successfully treated NIV. Acidotic relatively common under-recognized subtype further...
Established indications for non-invasive ventilation (NIV) include acute or acute-on-chronic type 2 respiratory failure associated with acidosis. It is commonly assumed that this acidosis a secondary phenomenon which follows the development of hypercapnia. This case series describes four patients acidotic hypercapnia (type to metabolic acidosis) demonstrated through serial arterial blood gases who were successfully treated NIV. Acidotic relatively common under-recognized subtype further...
Abstract Background: Venous thromboembolism (VTE) is a common complication in patients with anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) and confers significant morbidity mortality. Both acute past cytomegalovirus (CMV) infection have been identified as risk factors for VTE immunocompetent immunosuppressed individuals. Here we examine whether exposure to CMV factor amongst AAV. Methods: We retrospectively analysed outcomes of new diagnosis AAV from local cohort....