A5022615033- Crystallization and Solubility Studies
- Oxidative Organic Chemistry Reactions
- X-ray Diffraction in Crystallography
- Sulfur-Based Synthesis Techniques
- Radical Photochemical Reactions
- Carbohydrate Chemistry and Synthesis
- Various Chemistry Research Topics
- Enzyme Catalysis and Immobilization
- Enzyme function and inhibition
- Click Chemistry and Applications
- Synthesis and Catalytic Reactions
- Cyclopropane Reaction Mechanisms
- Chemical Synthesis and Analysis
- Bacterial Infections and Vaccines
- Adenosine and Purinergic Signaling
- Biochemical and Structural Characterization
- Monoclonal and Polyclonal Antibodies Research
- Porphyrin and Phthalocyanine Chemistry
- Chemical Reactions and Mechanisms
- Nanoplatforms for cancer theranostics
- Catalytic C–H Functionalization Methods
- Photodynamic Therapy Research Studies
École Polytechnique Fédérale de Lausanne
2024
University of Basel
2024
Institut Català d'Investigació Química
2021-2024
Universitat Rovira i Virgili
2022
University of Bologna
2019
Donostia International Physics Center
2018
Here we report the application of dual nickel/photoredox catalysis to allylation aliphatic, aromatic and heteroaromatic aldehydes by using commercially available reagents. The process utilizes combination a Ni(ii) complex, [Ru(bpy)3]2+ as photoredox catalyst, allylacetate under blue LED irradiation, allows synthesis large variety homoallylic alcohols.
Abstract We have recently demonstrated that riboflavin ( Rf ) functions as unconventional bioorthogonal photocatalyst for the activation of Pt IV prodrugs. In this study, we show how combination light and with two prodrugs is a feasible strategy light-mediated pancreatic cancer cell death induction. Capan-1 cells, which high tolerance against photodynamic therapy, -mediated cisplatin carboplatin cis , trans -[Pt(NH 3 2 (Cl) (O CCH CH CO H) ] 1 (CBDCA)(O where CBDCA = cyclobutane...
Abstract Asymmetric catalytic cascade processes offer direct access to complex chiral molecules from simple substrates and in a single step. In biocatalysis, cascades are generally designed by combining multiple enzymes, each catalyzing individual steps of sequence. Herein, we report different strategy for biocascades based on multifunctional enzyme that can promote stereoselective domino process mastering distinct mechanisms substrate activation sequential way. Specifically, have used an...
The assembly of artificial metalloenzymes (ArMs) provides a second coordination sphere around metal catalyst. Such well-defined microenvironment can lead to an enhancement the activities and selectivity Herein, we present development hydroxylase (ArHase) by embedding Fe-TAML (TAML = tetraamide macrocyclic ligand) catalyst into human carbonic anhydrase II (hCAII). Incorporation ([BS-Fe-bTAML]–) within hCAII enhanced total turnover number (TTON) for hydroxylation benzylic C–H bonds. After...
The assembly of artificial metalloenzymes provides a second coordination sphere around metal catalyst. Such well-defined microenvironment can lead to enhancing the activities and selectivity Herein, we present development hydroxylase (ArHase) by embedding Fe-TAML (TAML = Tetra Amide Macrocyclic Ligand) catalyst into human carbonic anhydrase II (hCAII). Incorporation ([BS-Fe-bTAML]–) within hCAII enhanced Total TurnOver Number (TTON) for hydroxylation benzylic C–H bonds. After engineering...
Abstract Ethynylbenziodoxol(on)es (EB(X)xs) reagents have emerged as useful for peptide/protein modification due to their versatile reactivity and high selectivity. Herein, we report the successful introduction of ethynylbenziodoxoles (EBxs) on different amino acid building blocks (Lys/Orn/Dap), show compatibility with both solid phase peptide synthesis (SPPS) solution (SPS). The selective incorporation EBx core into sequences enable efficient macrocyclizations under mild conditions...
Ethynylbenziodoxol(on)es (EB(X)xs) reagents have emerged as useful for peptide/protein modification due to their versatile reactivity and high selectivity. Herein, we report the successful introduction of ethynylbenziodoxoles (EBxs) on different amino acid building blocks (Lys/Orn/Dap), show compatibility with both solid phase peptide synthesis (SPPS) solution (SPS). The selective incorporation EBx core into sequences enable efficient macrocyclizations under mild conditions topologically...
Abstract Asymmetric catalytic cascade processes offer direct access to complex chiral molecules from simple substrates and in a single step. In biocatalysis, cascades are generally designed by combining multiple enzymes, each catalyzing individual steps of sequence. Herein, we report different strategy for biocascades based on multifunctional enzyme that can promote stereoselective domino process mastering distinct mechanisms substrate activation sequential way. Specifically, have used an...