A5043373551- Genetics and Neurodevelopmental Disorders
- Microtubule and mitosis dynamics
- Genomics and Chromatin Dynamics
- Photoreceptor and optogenetics research
- DNA Repair Mechanisms
- Retinal Development and Disorders
- Anesthesia and Neurotoxicity Research
- Plant and Biological Electrophysiology Studies
- Genomic variations and chromosomal abnormalities
- Pluripotent Stem Cells Research
- Planarian Biology and Electrostimulation
- Circadian rhythm and melatonin
- Neuroendocrine regulation and behavior
- Animal testing and alternatives
- Neurogenesis and neuroplasticity mechanisms
- Parasitic Infections and Diagnostics
- Protist diversity and phylogeny
- Receptor Mechanisms and Signaling
- Cephalopods and Marine Biology
- Amoebic Infections and Treatments
- Epigenetics and DNA Methylation
- Algal biology and biofuel production
- Chromatin Remodeling and Cancer
- Fetal and Pediatric Neurological Disorders
- Neurobiology and Insect Physiology Research
Université de Strasbourg
2022-2025
Institut des Neurosciences Cellulaires et Intégratives
2019-2025
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2023
Université Paris Cité
2014-2023
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses
2023
Inserm
2014-2023
Institut de Radiobiologie Cellulaire et Moléculaire
2014-2023
Université Paris-Saclay
2020-2023
CEA Paris-Saclay
2023
Stabilité Génétique, Cellules Souches et Radiations
2020
Daily rhythms are a central hallmark of vision, in particular by adapting retinal physiology and light response to the day-night cycle. These cyclic processes regulated circadian clocks, molecular machineries regulating gene expression across 24-h Although hundreds genes associated with genetic disorders have been identified, no direct link has established clock. Hence, we investigated hypothesis that poorly functioning clock aggravates photoreceptor disease. We performed this study P23H...
To provide new insights into the FOXG1-related clinical and imaging phenotypes refine phenotype-genotype correlation in FOXG1 syndrome.We analyzed of a cohort 45 patients with pathogenic or likely variant performed correlations.A total 37 different heterozygous mutations were identified, which 18 are novel. We described broad spectrum neurodevelopmental phenotypes, characterized by severe postnatal microcephaly developmental delay accompanied hyperkinetic movement disorder, stereotypes sleep...
The neuroarchitecture of Acoela has been at the center morphological debates. Some authors, using immunochemical tools, suggest that nervous system in is organized as a commissural brain bears little resemblance to central, ganglionic type other flatworms, and bilaterians general. Others, who used histological staining on paraffin sections, conclude it compact structure (an endonal brain; e.g., Raikova 2004; von Graff 1891; Delage Arch Zool Exp Gén 4:109-144, 1886). To address this question...
Protists that live under low-oxygen conditions often lack conventional mitochondria and instead possess mitochondrion-related organelles (MROs) with distinct biochemical functions. Studies of mostly parasitic organisms have suggested these could be classified into two general types: hydrogenosomes mitosomes. Hydrogenosomes, found in parabasalids, anaerobic chytrid fungi, ciliates, metabolize pyruvate anaerobically to generate ATP, acetate, CO(2), hydrogen gas, employing enzymes not typically...
Bery, A. and Martínez, P. 2010. Acetylcholinesterase activity in the developing regenerating nervous system of acoel Symsagittifera roscoffensis. —Acta Zoologica (Stockholm) 92: 383–392. The use cholinergic is widespread animal kingdom. It controls different processes, including reproduction neural transmission. However, its evolutionary history not yet well understood. For instance, role played by basal bilaterian taxa, where first signs architectural complexity appear, still unknown. Here,...
XLF/Cernunnos is a component of the ligation complex used in classical non-homologous end-joining (cNHEJ), major DNA double-strand break (DSB) repair pathway. We report neurodevelopmental delays and significant behavioral alterations associated with microcephaly Xlf-/- mice. This phenotype, reminiscent clinical neuropathologic features humans deficient cNHEJ, low level apoptosis neural cells premature neurogenesis, which consists an early shift progenitors from proliferative to neurogenic...
Neurons of the cerebral cortex are generated during brain development from different types neural stem and progenitor cells (NSPC), which form a pseudostratified epithelium lining lateral ventricles embryonic brain. Genotoxic stresses, such as ionizing radiation, have highly deleterious effects on developing related to high sensitivity NSPC. Elucidation cellular molecular mechanisms involved depends characterization DNA damage response these particular cells, requires an accurate method...
Neurons of the cerebral cortex are generated during brain development from different types neural stem and progenitor cells (NSPC), which form a pseudostratified epithelium lining lateral ventricles embryonic brain. Genotoxic stresses, such as ionizing radiation, have highly deleterious effects on developing related to high sensitivity NSPC. Elucidation cellular molecular mechanisms involved depends characterization DNA damage response these particular cells, requires an accurate method...
XLF/Cernunnos is a component of the ligation complex used in classical non-homologous end joining (cNHEJ), major DNA double strand break (DSB) repair pathway.We evidenced neurodevelopmental delays and significant behavioral alterations associated to microcephaly Xlf-/- mice. This phenotype, reminiscent clinical neuropathologic features humans deficient cNHEJ, related low level apoptosis differentiating neural cells, but primarily premature neurogenesis during brain development. We show that...