ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTNMR Chemical Shifts of Common Laboratory Solvents as Trace ImpuritiesHugo E. Gottlieb, Vadim Kotlyar, and Abraham NudelmanView Author Information Department Chemistry, Bar-Ilan University, Ramat-Gan 52900, IsraelCite this: J. Org. Chem. 1997, 62, 21, 7512–7515Publication Date (Web):October 17, 1997Publication History Received27 June 1997Published online17 October inissue 1...

Tables of 1H and 13C NMR chemical shifts have been compiled for common organic compounds often used as reagents or found products contaminants in deuterated solvents. Building upon the work Gottlieb, Kotlyar, Nudelman Journal Organic Chemistry, signals impurities are now reported additional solvents (tetrahydrofuran-d8, toluene-d8, dichloromethane-d2, chlorobenzene-d5, 2,2,2-trifluoroethanol-d3) which frequently organometallic laboratories. Chemical other organics internal standards...

Abstract Doxorubicin (Adriamycin) is one of the most commonly used chemotherapeutic drugs and exhibits a wide spectrum activity against solid tumors, lymphomas, leukemias. classified as topoisomerase II poison, although other mechanisms action have been characterized. Here, we show that doxorubicin-DNA adducts (formed by coadministration doxorubicin with non-toxic doses formaldehyde-releasing prodrugs) induce more cytotoxic response in HL-60 cells than single agent. Doxorubicin-DNA seem to...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies in sugar chemistry. 2. A simple method for O-deacylation of polyacylated sugarsJacob Herzig, Abraham Nudelman, Hugo E. Gottlieb, and Bilha FischerCite this: J. Org. Chem. 1986, 51, 5, 727–730Publication Date (Print):March 1, 1986Publication History Published online1 May 2002Published inissue 1 March 1986https://pubs.acs.org/doi/10.1021/jo00355a026https://doi.org/10.1021/jo00355a026research-articleACS PublicationsRequest reuse...

Abstract Hydrogen chloride qualitatively generated in situ by the addition of acetyl to alcoholic solutions is a useful reagent for carboxylic acid esterification, N-t-Boc deprotection and phosphoramide solvolysis reactions.

Abstract A novel derivative of butyric acid, pivalyloxymethyl butyrate (AN‐9) has been shown, in vitro , to: (a) induce cytodifferentiation and inhibit the proliferation leukemic cells; (b) growth formation Lewis lung carcinoma colonies semi‐solid agar. AN‐9 affect cells at about 10‐fold lower concentration a faster rate than does acid. The esters propionic, isobutyric valeric acids do not elicit effects similar to those AN‐9, while isobutyryloxymethyl does, which strongly suggests that...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganotin nucleophiles. 6. Palladium-catalyzed allylic etherification with tin alkoxidesEhud Keinan, Mahendra Sahai, Zeev Poth, Abraham Nudelman, and Jacob HerzigCite this: J. Org. Chem. 1985, 50, 19, 3558–3566Publication Date (Print):September 1, 1985Publication History Published online1 May 2002Published inissue 1 September 1985https://pubs.acs.org/doi/10.1021/jo00219a023https://doi.org/10.1021/jo00219a023research-articleACS PublicationsRequest...

The cascade of events that occurs in Alzheimer's disease involving oxidative stress and the reduction cholinergic transmission can be better addressed by multifunctional drugs than cholinesterase inhibitors alone. For this purpose, we prepared a large number derivatives indoline-3-propionic acids esters. They showed scavenging activity against different radicals solution significant protection cytotoxicity cardiomyocytes primary cultures neuronal cells exposed to H2O2 species serum...

We describe the preparation and evaluation of novel indoline derivatives with potent antioxidant anti-inflammatory activities for treatment pathological conditions associated chronic inflammation. The indolines are substituted at position 1 chains carrying amino, ester, amide, or alcohol groups, some have additional substituents, Cl, MeO, Me, F, HO, BnO, on benzo ring. Concentrations pM to nM several compounds protected RAW264.7 macrophages against H2O2 induced cytotoxicity LPS elevation NO,...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel anticancer prodrugs of butyric acid. 2Abraham Nudelman, Margaretta Ruse, Adina Aviram, Ester Rabizadeh, Matityahu Shaklai, Yael Zimrah, and Ada RephaeliCite this: J. Med. Chem. 1992, 35, 4, 687–694Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://pubs.acs.org/doi/10.1021/jm00082a009https://doi.org/10.1021/jm00082a009research-articleACS PublicationsRequest reuse...

Histone modification has emerged as a promising approach to cancer therapy. We explored the efficacy of novel class histone deacetylase inhibitors in treatment malignant gliomas. Treatment glioma cell lines with two butyric acid derivatives, pivaloylomethyl butyrate (AN-9) and butyroyloxymethyl (AN-1), induced hyperacetylation, increased p21(Cip1) expression, inhibited proliferation, enhanced apoptosis. inhibitor-induced apoptosis was mediated primarily by caspase-8. cells AN-1 or AN-9 for...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe stereochemical course of ester-amide interchange leading to optically active phosphinic and sulfinic amidesAbraham Nudelman Donald J. CramCite this: Am. Chem. Soc. 1968, 90, 14, 3869–3870Publication Date (Print):July 1, 1968Publication History Published online1 May 2002Published inissue 1 July 1968https://pubs.acs.org/doi/10.1021/ja01016a053https://doi.org/10.1021/ja01016a053research-articleACS PublicationsRequest reuse permissionsArticle...

We describe the synthesis, biological activities, and clinical applications of a novel family butyric acid (BA) prodrugs having general formula Me(CH2)2COOCH(R)OR1, where R = H, Me, Pr, tert-Bu; R1 OC-alkyl, OC-Ar, OC-heterocycles , P(O)(OEt)2. These acyloxyalkyl serve as molecular devices for efficient transport BA into cells, leading to significant increase in its potency. The were studied anticancer activity, induction hemoglobin (Hb) expression protection hair follicles from damage...

The syn-rotamers of carbamate derivatives α-amino acids are shown to be stabilized by the formation H-bond complexes with carboxylic acid moieties in solution. This effect is, as expected, concentration and temperature dependent. Thermodynamic parameters (both ΔG° ΔG‡) for N-Boc-alanine were determined NMR ±60 °C range.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA novel method for stereoselective glucuronidationBilha Fischer, Abraham Nudelman, Margareta Ruse, Jacob Herzig, Hugo E. Gottlieb, and Ehud KeinanCite this: J. Org. Chem. 1984, 49, 25, 4988–4993Publication Date (Print):December 1, 1984Publication History Published online1 May 2002Published inissue 1 December 1984https://pubs.acs.org/doi/10.1021/jo00199a046https://doi.org/10.1021/jo00199a046research-articleACS PublicationsRequest reuse...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnthalpies of transfer transition states in the Menshutkin reaction from a polar protic to dipolar aprotic solventPaul Haberfield, Abraham Nudelman, Allen Bloom, Richard Romm, and Henry GinsbergCite this: J. Org. Chem. 1971, 36, 13, 1792–1795Publication Date (Print):July 1, 1971Publication History Published online1 May 2002Published inissue 1 July 1971https://pubs.acs.org/doi/10.1021/jo00812a016https://doi.org/10.1021/jo00812a016research-articleACS...

The novel prodrug of butyric acid (BA), pivaloyloxymethyl butyrate, has been shown, in vitro, to induce differentiation and inhibit leukemic cell proliferation. affects the cells vitro at lower concentration least 100 times faster than does (BA). We have compared ability BA with that its AN‐9 modulate expression early regulating genes, c‐ myc jun , HL‐60 cells. Exposure resulted a decrease an increase expression. elicited this effect concentrations BA. Since changes occur minutes after...