A5017566598- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Lymphoma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Salivary Gland Tumors Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Immune Cell Function and Interaction
- Ear and Head Tumors
- Cell Adhesion Molecules Research
- Autoimmune Bullous Skin Diseases
- Oral Health Pathology and Treatment
- Colorectal Cancer Screening and Detection
- Nonmelanoma Skin Cancer Studies
- Skin and Cellular Biology Research
- Radiomics and Machine Learning in Medical Imaging
- Cancer therapeutics and mechanisms
- Hip and Femur Fractures
- Tracheal and airway disorders
- Nail Diseases and Treatments
- CAR-T cell therapy research
- Viral-associated cancers and disorders
Peter MacCallum Cancer Centre
2018-2025
The University of Melbourne
2018-2025
Olivia Newton-John Cancer Wellness & Research Centre
2019-2024
Austin Health
2014-2024
Austin Hospital
2019-2020
Northern Health
2017
Northern Hospital
2016
Oniris
2016
No systemic therapies have been approved for the treatment of advanced cutaneous squamous-cell carcinoma. This cancer may be responsive to immune therapy, because mutation burden tumor is high and disease risk strongly associated with immunosuppression. In dose-escalation portion phase 1 study cemiplimab, a deep durable response was observed in patient metastatic carcinoma.We report results cemiplimab expansion cohorts patients locally or carcinoma, as well pivotal 2 cohort...
Recessive dystrophic epidermolysis bullosa (RDEB) belongs to a rare group of inherited dermatoses, which are characterised by mucosal and cutaneous fragility. Cutaneous squamous cell carcinoma (CSCC) is common complication RDEB. In the severe subtype RDEB (RDEB-S), CSCC observed in 90% patients 55 years. with follows an aggressive course median survival rate 2.4 We report case 51-year-old female recurrent right lateral-back. She was commenced on cemiplimab, anti-programmed death receptor-1...
A multidisciplinary approach to the management of tongue cancer is vital for achieving optimal patient outcomes. Nursing and allied health professionals play essential roles within team. We developed symposia comprising a series online lectures offering detailed perspective on role each discipline consumer has in patients with cancer. The topics, including epidemiology prevention, diagnosis, treatment planning, surgery, adjuvant care, recurrent or metastatic disease, were thoroughly...
The treatment of head and neck cancers (HNCs) encompasses a complex paradigm involving combination surgery, radiotherapy, systemic treatment. Locoregional recurrence is common cause failure, few patients are suitable for salvage surgery. Reirradiation with conventional radiation techniques challenging due to normal tissue tolerance limits the risk significant toxicities. Stereotactic body radiotherapy (SBRT) has emerged as highly conformal modality that offers potential cure while limiting...
The purpose of this study was to assess the efficacy using rapid on-site evaluation (ROSE) for samples taken during endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) at Austin Health, Victoria. This compared data collected cases performed without ROSE. A retrospective analysis conducted on 188 consecutive patients who underwent EBUS-TBNA from May 2012 July 2014 whose prospectively time procedure. presence a cytologist ROSE resulted in significant reduction number...
Abstract Background Globally, racial and ethnic disparities exist in treatments outcomes for cancer patients. In Australia, there are few published data related to patients from culturally linguistically diverse ( CALD ) backgrounds. Aim To explore adjuvant chemotherapy utilisation groups. Methods Retrospective analysis of who were recommended early stage breast or colorectal between July 2011 October 2014 was performed. Rates uptake analysed those identified English as their first‐preferred...
Abstract In Australia, mutations in epidermal growth factor ( EGFR ) occur 15% of patients diagnosed with non‐small‐cell lung cancer and are found higher frequency female, non‐smokers Asian ethnicity. Activating the gene rarely described SCLC . We present two cases de novo detected tissue plasma cell free DNA , both whom were ethnicity never‐smokers. These add to growing body evidence suggesting that screening for should be considered specific clinical features.
ABSTRACT Background The success of BH3 mimetics in hematological malignancies has spurred interest their application solid tumors. We examined the expression BCL‐2 family molecules NPC tumors and cell lines explored anticancer efficacy vitro. Methods Immunohistochemistry for BCL‐2, MCL‐1, BCL‐xL, transcriptomic analyses was conducted on ABT‐199, S63845, ABT‐737 were as monotherapy combination with cisplatin lines. RNA sequencing performed to identify up downregulated pathways sensitive...
e18063 Background: Racial disparities have been identified in the treatment of cancer patients worldwide, often associated with differences outcomes. International data has shown reduction cancer-related mortality general population that is not paralleled migrant populations. Differences include uptake adjuvant chemotherapy for potentially curable cancers. Possible reasons this are barriers such as language, health beliefs and access to healthcare. Australia a large CALD population; however,...
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<p>Staging Methods KM curves</p>
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<div>Abstract<p>Human papilloma virus–positive oropharyngeal squamous cell carcinoma (HPV<sup>+</sup> OPSCC) represents a distinct subgroup of head and neck cancers associated with clinical outcomes that are not accurately categorized by existing tumor–node–metastasis-based staging methods. Given the significant impact immune parameters, such as tumor-infiltrating lymphocytes (TIL) in many cancers, we sought to determine if immunophenotyping tumors can improve...
<p>Staging Methods KM curves</p>
<p>p16 OS KM curves</p>
<p>Scoring Method</p>
<p>Consort diagram</p>
<p>Dual stain example</p>
<p>Scoring Method</p>