A5050907537- Cutaneous Melanoma Detection and Management
- Immunotherapy and Immune Responses
- Nonmelanoma Skin Cancer Studies
- Dermatology and Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Melanoma and MAPK Pathways
- CAR-T cell therapy research
- Photodynamic Therapy Research Studies
- Immune Cell Function and Interaction
- Urticaria and Related Conditions
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Allergic Rhinitis and Sensitization
- Skin Protection and Aging
- melanin and skin pigmentation
- Optical Coherence Tomography Applications
- Cell Adhesion Molecules Research
- Ocular Oncology and Treatments
- Cancer Immunotherapy and Biomarkers
- Asthma and respiratory diseases
- Nanoplatforms for cancer theranostics
- Toxin Mechanisms and Immunotoxins
- Autoimmune Bullous Skin Diseases
- Computational Drug Discovery Methods
- Food Allergy and Anaphylaxis Research
Diagnostic and Treatment Centre Berlin
2019-2024
Saarland University
1997-2023
Fundación Instituto Valenciano de Oncología
2023
Aristotle University of Thessaloniki
2023
Hospital Infantil Universitario Niño Jesús
2023
Helsinki University Hospital
2023
Technical University of Munich
2023
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2023
University Hospital Bonn
2006-2018
German Doctors
2013
To determine the predictive value of angiogenic serum factors angiogenin, vascular endothelial growth factor (VEGF), basic fibroblast (bFGF), and interleukin-8 (IL-8) for prognosis patients with malignant melanoma.Angiogenin, VEGF, bFGF, IL-8 were measured in sera 125 melanoma different stages disease or without current therapy including interferon alfa cytostatics comparison 30 healthy controls using enzyme-linked immunosorbent assay.Serum levels significantly increased compared controls....
Even though progress has been made, the detection of melanoma still poses a challenge. In light this situation, Nevisense electrical impedance spectroscopy (EIS) system (SciBase AB, Stockholm, Sweden) was designed and shown to have potential be used as an adjunct diagnostic tool for detection.To assess effectiveness safety in distinction benign lesions skin from with spectroscopy.This multicentre, prospective, blinded clinical study conducted at five American 17 European investigational...
Photodynamic therapy (PDT) with 5-aminolaevulinic acid (ALA) or its methylester [methyl-5-aminolaevulinate (MAL) 5-amino-4-oxopentanoate] was recently ranked as first-line for the treatment of actinic keratosis (AK) and is an accepted therapeutic option neoplastic skin diseases. BF-200 ALA (Biofrontera Bioscience GmbH, Leverkusen, Germany) a gel formulation nanoemulsion AK which overcomes previous problems instability improves penetration.To evaluate efficacy safety PDT AKs in comparison...
The diagnostic criteria for basal cell carcinoma (BCC) using optical coherence tomography (OCT) have been described previously, but the clinical value of these findings remains unknown.To investigate OCT BCC in a typical setting. primary efficacy end point was diagnosis each lesion. Secondary points were other possible conditions.This an observational, prospective, multicentre study which consecutive patients with nonpigmented pink lesions suspicious underwent assessment, dermoscopy and OCT,...
The amplification of tyrosinase mRNA by reverse transcription-PCR (RT-PCR) from peripheral blood has frequently been used as a marker for the presence circulating tumor cells in melanoma patients (1). Recently, was also demonstrated to be detectable serum and plasma samples patients, indicating that tumor-specific is present an extracellular form bloodstream (2)(3). This confirmed other investigators demonstrating telomerase breast cancer (4). It speculated tumor-associated possibly related...
The nonclassic human major histocompatibility complex class I antigens leukocyte antigen (HLA)--G are proposed to protect tumor cells from natural killer cell lysis. In the current study, authors measured soluble HLA-G molecules (sHLA-G) in serum patients with malignant melanoma.Soluble was determined samples of 190 melanoma various stages disease, or without therapy including interferon (IFN)-alpha and different cytostatics comparison 126 healthy controls by using a two-step enzyme-linked...
The in vitro production of interferon-gamma (IFN-gamma) 19 atopic dermatitis (AD) patients was compared with that 12 controls. IFN-gamma by phytohaemagglutinin (PHA) stimulated peripheral blood mononuclear cells (PBMC) profoundly diminished AD patients, whereas the proliferative response similar to control PBMC. addition 40 U/ml interleukin-2 (IL-2) cultures failed restore production. Similarly, removal adherent also had no effect. Reduced secretion observed after stimulation CD3 monoclonal...
Melanoma is a malignant tumor that arises from melanocytic cells and primarily involves the skin. The most important exogenous etiological factor exposure to ultraviolet irradiation. Diagnosis of melanoma based on its clinical features, A–B–C–D rule useful in identifying pigmented lesions, which are suspicious for (Asymmetry, Border irregular, Color inhomogeneous Diameter more than 5 mm). Dermoscopy very helpful clarifying differential diagnosis lesions. About 90% melanomas diagnosed as...
Photodynamic therapy (PDT) is increasingly used for treatment of actinic keratoses (AKs) but a cumbersome procedure. A thin self-adhesive patch (PD P 506 A) containing 5-aminolaevulinic acid (5-ALA) was developed to facilitate PDT.To investigate efficacy and safety the in comparison with placebo-PDT (superiority design, observer-blinded; study AK 03) standard therapy, cryosurgery (noninferiority open; 04).Two separate confirmatory randomized parallel-group phase III studies were set up. In...
Journal Article Photodynamic therapy with BF‐200 ALA for the treatment of actinic keratosis: results a prospective, randomized, double‐blind, placebo‐controlled phase III study Get access R.‐M. Szeimies, Szeimies Department Dermatology, Regensburg University Hospital, Regensburg, Germany Search other works by this author on: Oxford Academic Google Scholar P. Radny, Radny Private Practice, Friedrichshafen, M. Sebastian, Sebastian Mahlow, F. Borrosch, Borrosch Vechta, T. Dirschka, Dirschka...
Two phase III trials of photodynamic therapy (PDT) with BF-200 ALA, a recently approved nanoemulsion formulation 5-aminolaevulinic acid (ALA) demonstrated high clearance rates in mild-to-moderate actinic keratosis (AK). The comparison to registered methyl aminolaevulinate (MAL) cream significantly superior total patient rates.To evaluate long-term efficacy and safety PDT for AK 6 12 months after the last MAL or placebo.The follow-up (FUP) was performed patients two studies. Both studies...
Background Previous studies have shown statistically significant differences in electrical impedance between various cutaneous lesions. Electrical spectroscopy (EIS) may therefore be able to aid clinicians differentiating benign and malignant skin Objectives The aim of the study was develop a classification algorithm distinguish melanoma lesions with sensitivity at least 98% specificity approximately 20 per cent higher than diagnostic accuracy dermatologists. Patients/Methods A total 1300...
Multiple actinic keratosis (AK) lesions may arise from the cancerization of large, sun‐damaged skin areas. Although photodynamic therapy (PDT) is considered most effective therapeutic option, efficacy and safety field treatment multiple AK with PDT has never before been tested in a pivotal trial. To evaluate efficacy, cosmetic outcome BF‐200 ALA (a nanoemulsion formulation containing 10% aminolaevulinic acid hydrochloride) combined BF‐RhodoLED® lamp for field‐directed mild‐to‐moderate PDT....
Basal cell carcinoma (BCC) represents the most common nonmelanoma skin cancer worldwide, affecting mainly adult, fair-skinned individuals. The World Health Organization distinguishes aggressive and nonaggressive forms, of which prototypical variants latter are primary nodular superficial BCC.To demonstrate noninferiority BF-200 ALA (a nanoemulsion gel containing 5-aminolaevulinic acid) compared with MAL cream methyl aminolaevulinate) in treatment BCC photodynamic therapy (PDT)....
Abstract In the peripheral blood of normal adults we identified a subpopulation mature human T cells that lacks expression CD7. These CD3+CD7- represent 9% +/- 3.4 SD PBMC as estimated by analyses 38 different donors. The majority CD7- express TCR alpha/beta, and are CD4 helper CD45RO+CD45RA- "memory" phenotype determined three-color fluorescence analysis. We established seven CD4+CD7- cell clones in vitro from purified compared these to CD4+CD7+ clones. Nonexpression expression,...
The primary treatment of a melanoma is surgical excision. An excisional biopsy preferred, and safety margins 1 cm for tumor thickness up to 2 mm higher should be applied either at excision or in two-step procedure. When dealing with facial, acral anogenital melanomas, micrographic control the may preferable allow reduced conservation tissue. sentinel lymph node performed patients whose thicker than 1.0 this operation centers where both operative nuclear medicine teams are experienced. In...
In vitro sensitivity assays are promising tools to predict the individual outcome of different chemotherapy regimens. However, a direct association between in and vivo chemosensitivity has be shown by clinical studies. This multicenter phase II trial was aimed investigate efficacy sensitivity-directed, first-line metastasized melanoma patients, prove an therapy outcome.The primary study end point objective response; secondary points were safety, overall survival, progression-free survival....
Systemic medical treatment of melanoma is administered in the adjuvant and palliative setting. Adjuvant therapy may be considered patients with primary more than 1.5 mm tumor thickness regional node metastasis. Presently no indication for systemic chemotherapy or nonspecific immune-stimulatory agents outside controlled studies seen. Interferon-α first substance melanoma, which has shown to present a significant advantage some prospective randomized studies. Good arguments using interferon-α...
Background Photodynamic therapy with a self‐adhesive 5‐aminolaevulinic acid (5‐ALA) patch shows high efficacy rates in the treatment of mild to moderate actinic keratosis (AK) short term trials. Objectives The purpose trial was follow up patients after successful 5‐ALA patch‐PDT at 3 month intervals over total period 12 months. Patients who had received placebo‐PDT or cryosurgery served for comparison. Patients/methods Three months therapy, 360 from two separate randomized parallel group...
Annually 133.000 people world-wide get sick on malign melanoma, tendency increasing. The purpose of this study is the early diagnosis malignant skin cancer. At moment dermatologists are screening for anomalies at relevant lesion by examining area with a microscope. To determine changes, another scan has to be taken in follow-up session after time period about 15-20 weeks. Today's visual diagnostic decision based pragmatic ABCD-approach (Asymmetry, Border, Colour, and Diameter). However,...