A5059527796- Cell death mechanisms and regulation
- Gut microbiota and health
- Tea Polyphenols and Effects
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Food Quality and Safety Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Diet and metabolism studies
- Phytochemicals and Antioxidant Activities
- Cytokine Signaling Pathways and Interactions
- Hippo pathway signaling and YAP/TAZ
- Immune cells in cancer
- Bioactive natural compounds
- Clostridium difficile and Clostridium perfringens research
- PI3K/AKT/mTOR signaling in cancer
- Tryptophan and brain disorders
- Barrier Structure and Function Studies
- Digestive system and related health
University of Pennsylvania
2020
University of Baltimore
2020
University of Maryland, Baltimore
2020
University of North Carolina at Chapel Hill
2012-2013
Indiana University School of Medicine
2004-2013
Indiana University – Purdue University Indianapolis
2004-2009
Walther Cancer Foundation
2004
Phosphatidylinositol (PI) 3-kinase/Akt signaling activates NF-κB through pleiotropic, cell type-specific mechanisms. This study investigated the significance of PI to tumor necrosis factor (TNF)-induced activation in transformed, immortalized, and primary cells. Pharmacological inhibition 3-kinase blocked TNF-induced DNA binding 293 line embryonic kidney cells, partially affected MCF-7 breast cancer HeLa ME-180 cervical carcinoma NIH 3T3 cells but was without significant effect H1299 human...
Oxymatrine is a traditional Chinese herbal product that exhibits anti-inflammatory effects in models of heart, brain and liver injury. We investigated the impact oxymatrine an acute model intestinal injury inflammation. significantly decreased LPS-induced NF-κB-driven luciferase activity, correlating with diminished induction Cxcl2, Tnfα Il6 mRNA expression rat IEC-6 murine BMDC. Although p65 nuclear translocation binding to Cxcl2 gene promoter, this effect was independent IκBα...
The capacity of DNA damaging agents to induce apoptosis is regulated by target gene induction p53. We found that p53 targeted MDM2 in cells which repair was occurring, but persistent damage induced chemotherapy led selectively PTEN. High dose the phosphorylation on serine 46, whereas low did not. A nonphosphorylatable 46 alanine mutant (S46A) promoter preference for aspartate (S46D, a mimic) PTEN MDM2. These observations show sufficient it (phosphatase and tensin homolog deleted chromosome...
Background Theaflavins including theaflavin (TF), theaflavin-3-gallate (TF3G), theaflavin-3′-gallate (TF3′G), and theaflavin-3,3′-digallate (TFDG), are the most important bioactive polyphenols in black tea. Because of their poor systemic bioavailability, it is still unclear how these compounds can exert biological functions. The objective this study to identify microbial metabolites theaflavins mice humans. Methods Findings In present study, we gavaged specific pathogen free (SPF) germ (GF)...
The intestine is a highly dynamic environment that requires tight control of the various inputs to maintain homeostasis and allow for proper responses injury. It was recently found stem cell niche epithelium regenerated after injury by de-differentiated adult cells, through process gives rise Sca1+ fetal-like cells driven transient population Clu
As a popular beverage, tea ( Camellia sinensi s, Theaceae) has been associated with many beneficial health effects, including the prevention of cancer and heart disease, phenomenon mostly attributed to presence polyphenolic compounds. The main bioactive polyphenols in black are theaflavins, which formed by oxidation polymerization catechins green leaves during fermentation. Theaflavins theaflavin (TF), theaflavin‐3‐gallate (TF3G), theaflavin‐3′‐gallate (TF3′G), theaflavin‐3,3′‐digallate...
Background After injury, intestinal epithelial cells can regenerate the epithelium and stem cell niche by de‐differentiating through a process recently defined as paligenosis. In intestine, this is marked YAP‐dependent‐induction of Sca‐1 + /Clu regenerative cells, but other signaling pathways that regulate program are unknown. Here we show protein TNFAIP8 (aka TIPE0) critical regulator homeostasis functions inhibition basal microbiome‐dependent PI3K/Akt signaling. Results Loss TIPE0 results...