A5039097495- Endoplasmic Reticulum Stress and Disease
- Hematopoietic Stem Cell Transplantation
- Phagocytosis and Immune Regulation
- Acute Lymphoblastic Leukemia research
- Pancreatitis Pathology and Treatment
- Renal Transplantation Outcomes and Treatments
University of Michigan–Ann Arbor
2016-2019
Abstract Calreticulin is a calcium-binding chaperone that normally localized in the endoplasmic reticulum. detectable on surface of apoptotic cells under some apoptosis-inducing conditions, where it promotes phagocytosis and immunogenicity dying cells. However, precise mechanism by which calreticulin, soluble protein, localizes to outer plasma membrane unknown, as are molecular mechanisms relevant calreticulin-induced cellular phagocytosis. comprises three distinct structural domains:...
Background Achieving therapeutic tacrolimus blood concentrations is crucial for decreasing the risk of developing acute graft-versus-host-disease (aGvHD) in allogeneic hematopoietic stem cell transplant (aHSCT) patients. Studies have suggested that levels first 1-2 weeks may affect aGVHD but goals are not well established. This study explores and GVHD during time frame. Methods a retrospective cohort single center chart review performed with 348 consecutive adult patients who received an...