Graeme Dor
A5039614670- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Plant Virus Research Studies
- Insect-Plant Interactions and Control
- Molecular Communication and Nanonetworks
- Plant Parasitism and Resistance
- Vector-Borne Animal Diseases
- Tuberculosis Research and Epidemiology
- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
- COVID-19 epidemiological studies
- Biosensors and Analytical Detection
- Viral Infections and Vectors
- Global Maternal and Child Health
- COVID-19 Clinical Research Studies
- Molecular Biology Techniques and Applications
- HIV/AIDS Impact and Responses
- Animal Virus Infections Studies
- Pneumonia and Respiratory Infections
- Vaccine Coverage and Hesitancy
- CRISPR and Genetic Engineering
Stellenbosch University
2024-2025
University of the Witwatersrand
2021-2023
National Health Laboratory Service
2022
Abstract Three lineages (BA.1, BA.2 and BA.3) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant concern predominantly drove South Africa’s fourth Coronavirus Disease 2019 (COVID-19) wave. We have now identified two new lineages, BA.4 BA.5, responsible for a fifth wave infections. The spike proteins BA.5 are identical, similar to except addition 69–70 deletion (present in Alpha BA.1 lineage), L452R Delta variant), F486V wild-type amino acid at Q493. differ...
Abstract South Africa’s fourth COVID-19 wave was driven predominantly by three lineages (BA.1, BA.2 and BA.3) of the SARS-CoV-2 Omicron variant concern. We have now identified two new lineages, BA.4 BA.5. The spike proteins BA.5 are identical, comparable to except for addition 69-70del, L452R, F486V wild type amino acid at Q493. 69-70 deletion in allows these be proxy marker S-gene target failure with TaqPath™ qPCR assay. rapidly replaced BA.2, reaching more than 50% sequenced cases Africa...
Abstract In March 2024, the Pan American Health Organization (PAHO) issued an alert in response to a rapid increase Oropouche fever cases across South America. Brazil has been particularly affected, reporting novel reassortant lineage of virus (OROV) and expansion previously non-endemic areas beyond Amazon Basin. Utilising phylogeographic approaches, we reveal multi-scale process with both short long-distance dispersal events, diffusion velocities line human-mediated jumps. We identify...
Background West Nile Virus (WNV) is a zoonotic flavivirus of significant One Health relevance and classified as priority pathogen with high-risk causing public health emergencies global concern. WNV endemic to Africa; however, the availability genomic sequences from continent remains limited. Methods We review extent polymerase chain reaction testing sequencing conducted across Africa. Using phylogeographic methods, we map spatiotemporal spread virus globally. Findings Our study shows that...
Summary Oropouche virus (OROV) is an emerging arbovirus with increasing outbreaks in South America, yet its environmental drivers and potential range remain poorly understood. Using ecological niche modeling (ENM) random forests, we assessed the suitability of OROV primary vector, Culicoides paraensis , across Brazil Americas. We evaluated five pseudo-absence sampling techniques, considering ratios, buffer radii, density smoothing factors to determine most effective approach. Key predictors...
The high demand for SARS-CoV-2 tests but limited supply to South African laboratories early in the COVID-19 pandemic resulted a heterogenous diagnostic footprint of open and closed molecular testing platforms being implemented. Ongoing monitoring performance these multiple varied systems required novel approaches, especially during circulation variants. National Health Laboratory Service centrally collected cycle threshold (Ct) values from 1,497,669 test results reported 6 commonly used PCR...
The high demand for SARS-CoV-2 tests but limited supply to South African laboratories early in the COVID19 pandemic, resulted a heterogenous diagnostic footprint of open and closed molecular testing platforms. Novel approaches were required monitor test quality especially during introduction newly circulating variants. National Health Laboratory Service centrally collected cycle threshold (Ct) values from 1,497,669 results reported six commonly used PCR assays 36 months, visually monitored...
Abstract The National Health Laboratory Service (NHLS) collects all public health laboratory test results in South Africa, providing a cohort from which to identify groups, by age, sex, HIV, and viral suppression status, that would benefit increased tuberculosis (TB) testing. Using NHLS data (2012–2016), we assessed levels trends over time TB diagnostic tests performed (count per capita) positivity. Estimates were stratified HIV suppression, province. We used logistic regression estimate the...
Abstract Human migration facilitates the spread of infectious disease. However, little is known about contribution to tuberculosis in South Africa. We analyzed longitudinal data on all test results recorded by Africa’s National Health Laboratory Service (NHLS), January 2011–July 2017, alongside municipality-level flows estimated from 2016 African Community Survey. first assessed patterns people with laboratory-diagnosed and demographic predictors. then quantified impact cross-municipality...