A5035175647- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Cellular Mechanics and Interactions
- Insect and Arachnid Ecology and Behavior
- Epigenetics and DNA Methylation
- Plant Molecular Biology Research
- Hemiptera Insect Studies
- Cardiovascular Function and Risk Factors
- Shoulder Injury and Treatment
- Lower Extremity Biomechanics and Pathologies
- Extracellular vesicles in disease
- Insect Resistance and Genetics
- Plant and animal studies
- Insect Utilization and Effects
- Legume Nitrogen Fixing Symbiosis
- Sports injuries and prevention
- Sports Performance and Training
- Social Media and Politics
- Animal Behavior and Reproduction
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Shoulder and Clavicle Injuries
- Themes in Literature Analysis
- Cardiovascular and exercise physiology
Vanderbilt University
2023-2025
University of Georgia
2018-2020
University of Kansas
2019
The function of cytosine (DNA) methylation in insects remains inconclusive due to a lack mutant and/or genetic studies.Here, we provide evidence for the functional role maintenance DNA methyltransferase 1 (Dnmt1) an insect using experimental manipulation. Through RNA interference (RNAi), successfully posttranscriptionally knocked down Dnmt1 ovarian tissue hemipteran Oncopeltus fasciatus (the large milkweed bug). Individuals depleted Dnmt1, and subsequently methylation, failed reproduce. Eggs...
Sarcomeres are the basic contractile units within cardiac myocytes, and collective shortening of sarcomeres aligned along myofibrils generates force driving heartbeat. The alignment individual is important for proper generation, misaligned associated with diseases, including cardiomyopathies COVID-19. actin bundling protein, α-actinin-2, localizes to ‘Z-Bodies” sarcomere precursors ‘Z-Lines’ sarcomeres, has been used previously assess assembly maintenance. Previous measurements α-actinin-2...
DNA methylation is an important chromatin modification that can stably alter gene expression in cells and maintain genome integrity plants vertebrates. The function of outside these well-studied systems, however, unclear. Insects, particular, represent understudied group. Variation the level gains losses maintenance methyltransferase, DNMT1, across insect tree life suggests there much we don't understand about DMNT1 evolution. One constant studies examining patterns Dnmt1 insects...
Sarcomeres are the basic contractile units within cardiac myocytes, and collective shortening of sarcomeres aligned along myofibrils generates force driving heartbeat. The alignment individual is important for proper generation, misaligned associated with diseases including cardiomyopathies COVID-19. actin bundling protein, α-actinin-2, localizes to “Z-Bodies” sarcomere precursors “Z-Lines” sarcomeres, has been used previously assess assembly maintenance. Previous measurements α-actinin-2...
Abstract The function of cytosine (DNA) methylation in insects remains unknown. Here we provide evidence for the functional role maintenance DNA methyltransferase 1 ( Dnmt1 ) an insect using experimental manipulation. Through RNA interference (RNAi) successfully post-transcriptionally knocked down ovarian tissue hemipteran Oncopeltus fasciatus (the large milkweed bug). Individuals depleted , and subsequently methylation, failed to reproduce. Eggs were inviable declined number, nuclei...
Abstract Oncopeltus fasciatus males fed the ancestral diet of milkweed seeds prioritize reproduction over lifespan as evidenced by higher rates fertility and shorter lifespans than from same population adapted sunflower seeds. We examined proximate mechanisms which milkweed‐fed maintained late‐life fertility. tested hypothesis that older producing more, quality sperm. Our results, have more sperm, but their sperm do not viability, are in general agreement with other recent studies on how...
Cardiac sarcomeres generate the fundamental forces behind each heartbeat and are thought to contain only muscle-specific cytoskeletal proteins. We show that a widely expressed actin cross-linking protein, α-actinin 4 (ACTN4), is sarcomere component of human zebrafish heart in vivo iPSC-derived cardiac myocytes (CMs) vitro. A confluence biochemical experiments, immunofluorescence, AI modeling suggest ACTN4 forms heterodimeric complex with ACTN2 at Z-disc, border. depletion from iPSC-CMs...
Sarcomeres are the basic contractile units within cardiac myocytes, and collective shortening of sarcomeres aligned along myofibrils generates force driving heartbeat. The alignment individual is important for proper generation, misaligned associated with diseases including cardiomyopathies COVID-19. actin bundling protein, α-actinin-2, localizes to "Z-Bodies" sarcomere precursors "Z-Lines" sarcomeres, has been used previously assess assembly maintenance. Previous measurements α-actinin-2...
Sarcomeres are the basic contractile units within cardiac myocytes, and collective shortening of sarcomeres aligned along myofibrils generates force driving heartbeat. The alignment individual is important for proper generation, misaligned associated with diseases including cardiomyopathies COVID-19. actin bundling protein, α-actinin-2, localizes to “Z-Bodies” sarcomere precursors “Z-Lines” sarcomeres, has been used previously assess assembly maintenance. Previous measurements α-actinin-2...
Sarcomeres are the basic contractile units within cardiac myocytes, and collective shortening of sarcomeres aligned along myofibrils generates force driving heartbeat. The alignment individual is important for proper generation, misaligned associated with diseases, including cardiomyopathies COVID-19. actin bundling protein, α-actinin-2, localizes to ‘Z-Bodies” sarcomere precursors ‘Z-Lines’ sarcomeres, has been used previously assess assembly maintenance. Previous measurements α-actinin-2...
Purpose: Running-related injury (RRI) is common among competitive collegiate distance runners who participate in the sport of cross country and long track field. Many factors contribute to RRI. Therefore, purpose this study was determine if a 3D motion capture system’s performance analysis (PMA) report capable identifying predictive RRI during season. Methods: Thirty-one (17 male, 14 female, mean age = 20.5 ± 1.4 years) gave their consent investigation. Subjects were screened system provided...
Abstract DNA methylation is an important chromatin modification that can stably alter gene expression in cells and maintain genome integrity plants vertebrates. The function of outside these well-studied systems, however, unclear. Insects, particular, represent understudied group. Variation the level gains losses maintenance methyltransferase, DNMT1, across insect tree life suggests there much we don’t understand about DMNT1 evolution. One constant studies examining patterns Dnmt1 insects...