Bmi-1 and Mel-18 are structural homologues that belong to the Polycomb group of transcriptional regulators believed stably maintain repression gene expression by altering state chromatin at specific promoters. While a number clinical experimental observations have implicated in human tumorigenesis, role cancer cell growth has not been investigated. We report here short hairpin RNA-mediated knockdown either or medulloblastoma DAOY cells results inhibition proliferation, loss clonogenic...

A coding technique for improving the sensitivity of optical time domain reflectometry (OTDR) is proposed. The uses codes derived from Hadamard matrices and does not use correlation. realized by this new method shown to be superior that obtained using Golay codes.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>

Significance Smart devices characterized by micro-/nanotopographies, such as cracks, wrinkles, folds, etc., have been fabricated for widespread application. Here, with the combination of multiscale hierarchical architecture, ultrathin metal nanocoatings high optical/photothermal tunability and morphological versatility, surface/interface engineering, a set multifunctional multistimuli responsiveness was fabricated. These can adapt to external stimuli reversible instantaneous responses in...

Tissue destruction characterizes infection with Mycobacterium tuberculosis (Mtb). Type I collagen provides the lung's tensile strength, is extremely resistant to degradation, but cleaved by matrix metalloproteinase (MMP)-1. Fibroblasts potentially secrete quantitatively more MMP-1 than other lung cells. We investigated mechanisms regulating Mtb-induced collagenolytic activity in fibroblasts vitro and patients. Lung were stimulated conditioned media from Mtb-infected monocytes (CoMTb). CoMTb...

Layer by layer assembly of hybrid inorganic/organic membrane encapsulating the sulfur particle impedes polysulfide dissolution or protecting lithium metal.

Abstract A versatile wrinkle‐based micropatterned system with a film‐substrate structure is proposed, which contains hydrophilic film of polyvinyl alcohol or its composite laponite and hydrophobic substrate polydimethylsiloxane carbon black. The wrinkled features high design flexibility multistimuli responsiveness, can be activated by various mechanical methods, including vertical press scratch, gentle stretch‐and‐release, bend, analogous magneto‐mechanical electro‐mechanical modes....

Abstract A facile but highly effective mechanochromism design is reported that based on a bilayer structure consisting of sputter‐coated metal light‐shielding layer atop polydimethylsiloxane (PDMS) substrate containing fluorescent dye, featuring transverse and/or longitudinal microscale cracks when stretched. The crack opening width the upon stretching/releasing allows UV radiation to activate dye in PDMS matrix exhibit luminescent color, which can be easily tuned with choice dyes. strain...

Characterization of high-speed photodetectors by optical heterodyne and pulse response techniques is reported, the results are compared. Scalar deconvolution was used to obtain photodetector from measurements with effects measurement apparatus removed. Linearity detector verified, validating comparison in frequency domain using a Fourier transform data. The limited magnitude transfer function domain, since technique does not give phase information. Both sets corrected for their respective...

One of the obstacles to coherent fiber-optic communications is unpredictable polarization drift which necessitates use an active controlling system match polarizations signal and local oscillator. The must be maintained during reset any finite range components prevent loss data. A novel practical uses three liquid-crystal devices for matching process presented, required control algorithm its derivation are described in detail.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML"...

During vaginal delivery, the delivery requires fetal head to mold accommodate geometric constraints of birth canal. Excessive molding can produce brain injuries and long-term sequelae. Understanding loading during second stage labor (fully dilated cervix, active pushing, expulsion fetus) could thus help predict safety newborn delivery. To this end, study proposes a finite element model maternal canal environment that is capable predicting stresses experienced by at onset phase labor. Both...

The contributions of space charge to chromatic and trajectory aberrations accelerating electrons in a laser-illuminated photoelectron microscope are calculated. Average fluctuating components the electrostatic forces on particles considered spearately. average produce magnification change but no spread. Fluctuating effects include relaxation potential kinetic energy beam obeying Poisson emission statistics, transverse-to-longitudinal velocity by multiple scattering. is treated new way...

A series of ceria-supported iron and cobalt oxide catalysts were synthesized with incremental metal loadings to determine within a narrow range the monolayer surface coverage. Onset formation was monitored utilizing X-ray diffraction Raman spectroscopy identify presence microcrystalline Fe–oxide Co–oxide phases. Formation Fe2O3 Co3O4 phases found on 5.40 Fe/nm2 FeOx/CeO2 2.58 Co/nm2 CoOx/CeO2 catalysts, respectively, thus those densities approximate The sensitivity this approach confirmed by...

By employing a CW-pumped Nd:YAG laser in nonlinear fifth-harmonic generation experiments, the duration of pulses at 213 nm has been doubled and repetition frequency increased by factor 40 beyond earlier results.

Bursts of 1064 nm pulses at a repetition rate 120 kHz were generated by placing resonant, acoustooptic birefringence modulator inside the cavity flash-pumped Nd:YAG laser. The resulting pulse trains converted to 532, 266, and 213 three-step nonlinear generation process in crystals that permit 90° phase matching for these wavelengths. An average power 2.6 mW was achieved. This method develops much lower peak powers than are obtained with ordinary <tex...

Deformable electroluminescent devices (DELDs) with mechanical and photothermal adaptability are promising for new applications in smart soft electronics.

Solid-state battery technologies may play an integral role in the shift toward a carbon-neutral society. In comparison to inorganic solid electrolytes, polymer electrolytes are generally cheaper, lighter, and more flexible. addition, they impose lower interfacial impedance, their production is easier scale up. Recently, based on charge-transfer complexes (CTC) have been alleged support room-temperature ionic conductivities >1.0 mS cm–1. Currently, synthetic methodology ill-defined, open...

The activity of metallic anodes, such as Li, in water-containing electrolytes is essential for the development and realization high-energy-density battery systems like Li–air. Due to inherent incompatibility between Li water, pathways must be established allow these two materials coexist a system. In this work, formation transplantation water-protective SEIs on surface metal using ionic liquid allowed cycling organic electrolytes. Further, we found that could utilized successfully cycle from...

Photoelectrons generated by multiphoton absorption can be used to form images of evanescent waves or modes in optical waveguide surface structures. With high resolution electron optics, it is possible observe detail the photoelectron image that much smaller than light wavelength. This technique therefore may useful revealing submicron defects and visualizing wave phenomena. In this paper chatacteristics method are discussed, preliminary experiments which nonlinear photoemission GaAs LiNbO...

Deconvolution of measurement system effects from pulse response measurements is demonstrated to yield reproducible, accurate characterization the impulse (and vector frequency response) a photodetector or photoreceiver, as well intensity waveform an optical pulse. Calibration based on <3-ps FWHM (full width at half maximum) and 50-GHz 3-dB bandwidth electrical sampling system. Vector photodetector/photoreceiver >40 GHz source >30 are demonstrated. noise discussed.< <ETX...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIndustrial applications of recombinant DNA technologyMichael D. Jones and Jeffrey T. Fayerman Cite this: J. Chem. Educ. 1987, 64, 4, 337Publication Date (Print):April 1, 1987Publication History Received3 August 2009Published online1 April 1987Published inissue 1 1987https://doi.org/10.1021/ed064p337RIGHTS & PERMISSIONSArticle Views1014Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article...

Safe, aqueous synthetic routes for obtaining selenium and sulfur–selenium hybrid particles, with controlled shapes sizes.