A5033379660- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Tracheal and airway disorders
- Neuroendocrine Tumor Research Advances
- IgG4-Related and Inflammatory Diseases
- Soft tissue tumor case studies
- Medical Imaging and Pathology Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Pleural and Pulmonary Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiomics and Machine Learning in Medical Imaging
- Cancer Treatment and Pharmacology
- Peptidase Inhibition and Analysis
- Voice and Speech Disorders
- Neuroblastoma Research and Treatments
- Metastasis and carcinoma case studies
- Brain Metastases and Treatment
- Cancer Genomics and Diagnostics
- Cancer therapeutics and mechanisms
- Liver physiology and pathology
- Myasthenia Gravis and Thymoma
Kanazawa Medical Center
2009-2025
National Hospital Organization
2015-2025
Ishikawa Prefectural Central Hospital
2009-2015
Instituto de Arqueología-Mérida
2015
Kanazawa University
2006-2013
Komatsu (Japan)
2004-2012
Kanazawa University Hospital
2007-2012
Kouseiren Takaoka Hospital
2006-2009
AstraZeneca (United Kingdom)
2007
Abbott (United Kingdom)
2007
The aim of this study was to evaluate the usefulness EGFR mutation status in serum DNA as a means predicting benefit from gefitinib (IRESSA) therapy Japanese patients with non-small cell lung cancer (NSCLC). We obtained pairs tumour and samples 42 treated gefitinib. determined by direct sequencing method Scorpion Amplification Refractory Mutation System (ARMS) technology. mutations were detected eight seven patients. tumours consistent 39 (92.9%) pairs. strong correlations between both...
The albumin-bilirubin (ALBI) grade is an assessment tool for hepatic function and prognosis in patients with hepatocellular carcinoma (HCC). However, its significance non-small cell lung cancer (NSCLC) treated epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) remains unclear. We retrospectively investigated the relationship between pre-treatment ALBI hepatotoxicity treatment efficacy NSCLC receiving EGFR-TKIs.
The discovery of driver oncogenes has increased the need to obtain a sufficient amount tissue specimens for lung cancer diagnosis. Although endoscopic ultrasound (with bronchoscope)-guided fine-needle aspiration (EUS-B-FNA) is reportedly feasible and well-tolerated modality, additional advantages EUS-B-FNA are yet be thoroughly investigated. purpose this study was evaluate ability pathologic molecular diagnoses cancer.Among patients who were diagnosed between December 2010 2012 in our...
Background: The effects of inductive hyperthermia on lung cancer have yet to be fully investigated. Magnetic nanoparticles used in are made-to-order and expensive. This study was performed investigate the use ferucarbotran clarify whether using promotes antitumor vivo a cell line. Methods: We injected A549 cells subcutaneously into right thighs BALB/c nu/nu nude mice. Forty mice with xenografts were then classified three groups. Group 1 control group. All groups 2 3 had their tumors, group...
Background: Nivolumab efficacy in patients with non-small-cell lung cancer (NSCLC) and performance status (PS) of 2-4 is unclear.We aimed to compare survival, treatment efficacy, safety NSCLC poor PS who received nivolumab plus best supportive care (BSC) those BSC alone a palliative unit (PCU).Patients methods: This retrospective study included 99 consecutive or between December 2015 March 2018.Results: In total, 43 0-1 (good group) 20 (poor BSC; the remaining 36 PCU (PC group).Median...
Immunoglobulin (Ig)G4-related disease is a recently described systemic immune-mediated fibro-inflammatory that frequently occurs in tumorous form. Herein, we elucidated the clinicopathological and cytological characteristics of IgG4-related pleural lesions (PLs).Among 22 patients with PLs idiopathic aetiology, eight cases were diagnosed as IgG4-PL remaining 14 non-IgG4-PL according to comprehensive diagnostic criteria for disease. Cell block examination effusion (CBPE) was performed five six...
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are used for treating EGFR-mutated lung cancer, and osimertinib is effective in cases that acquired T790M mutations after treatment with the first- second-generation EGFR-TKIs. However, no study has evaluated its safety efficacy older patients. This phase II trial (jRCTs071180002) mutation-positive Japanese patients who were ≥75 years old had experienced relapse or progression previous EGFR-TKI treatment. Our report...
30–80% of outgrown asthma subjects develop symptoms again later in life. We investigated inflammation and function lower airway adolescents with former asthma. 326 never-smoking young adults (mean age 24.0 years) were interviewed special emphasis on history Diagnosis was based GINA guidelines. Former consisted ones a physician-diagnosed childhood asthma, who had been free without the use medication for at least 10 years prior to study. Provocative concentration methacholine causing 20% fall...
Background . Standard chemotherapy for advanced non-small-cell lung cancer (NSCLC) with preexisting interstitial disease (ILD) has not yet been established. Although a combination of carboplatin and paclitaxel is most frequently used patients NSCLC ILD, the safety efficacy plus nanoparticle albumin-bound (nab-paclitaxel) are to be elucidated. Objectives This study aimed evaluate nab-paclitaxel ILD. Methods retrospective included nine ILD who received as first-line at National Hospital...
A standard chemotherapy regimen for advanced thymic carcinoma has not yet been established. We treated 2 cases of with carboplatin plus nanoparticle albumin-bound (<i>nab</i>)-paclitaxel, and <i>nab</i>-paclitaxel maintenance therapy. The first case was a 68-year-old female, admitted dyspnea left shoulder pain. Chest computed tomography (CT) showed huge mass in the anterior mediastinum, pleural pericardial effusions, multiple lung metastases. Specimens obtained from...
: Awareness of the immune-related adverse event programmed cell death protein-1 (PD-1) inhibitor-induced pneumonitis is important. Herein, we report clinical course 3 patients suspected to have PD-1 after cessation inhibitor treatment. In case 1, a 62-year-old man was diagnosed with stage IVA adenocarcinoma. Nivolumab monotherapy prescribed as second-line therapy and later discontinued due financial reasons. Seven months final administration nivolumab, patient developed what...
We herein report an 80-year-old man with prostatic carcinoma who developed eosinophilic pneumonia and intrathoracic metastases. He presented shortness of breath, cough, fever as a chief complaint. Chest X-ray computed tomography showed bilateral pulmonary nodules, lymphadenopathy, right-sided consolidation. Positron emission (PET) using 18F-fluorodeoxyglucose (FDG) poor uptake in these nodules lymph nodes. The patient subsequently received pelvic scan, which revealed massively enlarged...
8096 Background: Epidermal growth factor receptor (EGFR) mutations, amplification, and K-ras mutations are known as predictive of the EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy in patients (pts) with NSCLC. Prognostic influences those biomarkers remain matter to be discussed. Methods: Consecutive pts advanced NSCLC who were examined genotype received 1st line cytotoxic chemotherapy enrolled. amplification mutation analyzed if sufficient tumor samples available. Results: 87 enrolled...
目的．80歳以上高齢者肺癌の外科治療成績につき検討を行った．方法．包括的呼吸リハビリテーションを導入し，2007年1月より2014年12月までに80歳以上高齢者肺癌31症例に手術を施行した．外科治療成績につき検討を行った．結果．手術術式は肺部分切除（部切）18例，肺葉切除（葉切）12例，区域切除（区切）1例であった．合併症の発生は6例（19.4%）に認め，手術関連死亡はなく，5年生存率55.5%，生存期間中央値30ヵ月であった．消極的縮小術群17例（部切16例，区切1例）と葉切群12例の治療成績に有意差は認めなかった．結論．80歳以上の高齢者肺癌において，手術適応と術式の選択を適切に定めれば，外科治療成績は良好な結果を期待できる可能性がある．
One-third of lung cancer patients present with life-threatening central airway obstruction (CAO). Two elderly were referred to our institution symptoms caused by CAO. In each case, thoracic computed tomography and a bronchoscopic examination revealed tumor obstructing the airway. The tumors resected endoscopically, patients' respiratory performance status remarkably improved. Both diagnosed an advanced stage adenocarcinoma harboring epidermal growth factor receptor (EGFR) mutations. They...