A5044209781- Fetal and Pediatric Neurological Disorders
- Reproductive Biology and Fertility
- RNA Research and Splicing
- Neurogenesis and neuroplasticity mechanisms
- Pluripotent Stem Cells Research
- Microtubule and mitosis dynamics
- Axon Guidance and Neuronal Signaling
- Barrier Structure and Function Studies
- Cancer-related molecular mechanisms research
- Neonatal and fetal brain pathology
- Advanced Neuroimaging Techniques and Applications
- Developmental Biology and Gene Regulation
- Sperm and Testicular Function
- MicroRNA in disease regulation
- Molecular Biology Techniques and Applications
- Adipose Tissue and Metabolism
- Renal and related cancers
- Agriculture Sustainability and Environmental Impact
- Hedgehog Signaling Pathway Studies
- Agricultural Innovations and Practices
- Nuclear Structure and Function
- Chromatin Remodeling and Cancer
- Agricultural Systems and Practices
- Craniofacial Disorders and Treatments
- Bacterial Infections and Vaccines
The University of Queensland
2017-2024
Park Centre for Mental Health
2024
Allen Institute for Brain Science
2021
Background: Nuclear factor I family members nuclear A and B play important roles during cerebral cortical development. regulate similar biological processes, as their expression patterns, regulation of target genes individual knockout phenotypes overlap. We hypothesised that the combined allelic loss Nfia Nfib would culminate in more severe defects cortex than a single member. Methods: immunofluorescence, co-immunoprecipitation, gene analysis immunohistochemistry on mouse models to...
Corpus callosum dysgenesis (CCD) is a congenital disorder that incorporates either partial or complete absence of the largest cerebral commissure. Remodelling interhemispheric fissure (IHF) provides substrate for callosal axons to cross between hemispheres, and its failure main cause CCD. However, it unclear whether defects in this process could give rise heterogeneity expressivity phenotypes seen human cases We identify incomplete IHF remodelling as key structural correlate range...
Embryonic genome activation (EGA) marks the transition from dependence on maternal transcripts to an embryonic transcriptional program. The precise temporal regulation of gene expression, specifically silencing Dux/murine endogenous retrovirus type L (MERVL) program during late 2-cell interphase, is crucial for developmental progression in mouse embryos. How this finely tuned achieved within specific window poorly understood. Here, using particle-tracking microrheology throughout...
Article10 October 2022Open Access Source DataTransparent process Two-step nuclear centring by competing microtubule- and actin-based mechanisms in 2-cell mouse embryos Yunan Ye orcid.org/0000-0001-9084-6314 The Christopher Chen Oocyte Biology Research Laboratory, Centre for Clinical Research, University of Queensland, Herston, QLD, Australia Contribution: Conceptualization, Resources, Data curation, Software, Formal analysis, Validation, Investigation, Visualization, Methodology, Writing -...
The forebrain hemispheres are predominantly separated during embryogenesis by the interhemispheric fissure (IHF). Radial astroglia remodel IHF to form a continuous substrate between for midline crossing of corpus callosum (CC) and hippocampal commissure (HC). Deleted in colorectal carcinoma (DCC) netrin 1 (NTN1) molecules that have an evolutionarily conserved function commissural axon guidance. CC HC absent Dcc Ntn1 knockout mice, while other commissures only partially affected, suggesting...
Abstract Puberty is a whole‐body event, driven by the hypothalamic integration of peripheral signals such as leptin or IGF‐1. In process puberty, reproductive development simultaneous to growth, including muscle growth. To enhance our understanding function related we performed transcriptome analyses samples from six pre‐ and post‐pubertal Brahman heifers ( Bos indicus ). Our aims were perform differential expression co‐expression derive regulatory gene network associate with puberty. As...
Females are endowed at birth with a fixed reserve of oocytes, which declines both in quantity and quality advancing age. Understanding the molecular mechanisms regulating oocyte is crucial for improving chances pregnancy success fertility clinics. In vitro culture systems enable researchers to analyse important genetic regulators maturation fertilisation. Here, we describe detail highly reproducible technique isolation fully grown mouse oocytes. We include considerations precautionary...
Abstract Corpus callosum dysgenesis (CCD) is a congenital disorder that incorporates either partial or complete absence of the largest cerebral commissure. Remodelling interhemispheric fissure (IHF) provides substrate for callosal axons to cross between hemispheres, and its failure main cause CCD. However, it unclear whether defects in this process could give rise heterogeneity expressivity phenotypes seen human cases We identify incomplete IHF remodelling as key structural correlate range...
Abstract The forebrain hemispheres are predominantly separated during embryogenesis by the interhemispheric fissure (IHF). Radial astroglia remodel IHF to form a continuous substrate between for midline crossing of corpus callosum (CC) and hippocampal commissure (HC). DCC NTN1 molecules that have an evolutionarily conserved function in commissural axon guidance. CC HC absent Dcc Ntn1 knockout mice, while other commissures only partially affected, suggesting additional aetiology formation....