A5065378509- Pharmacy and Medical Practices
- Pharmacovigilance and Adverse Drug Reactions
- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- Pregnancy and Medication Impact
- Patient Safety and Medication Errors
- Chronic Myeloid Leukemia Treatments
- Drug-Induced Adverse Reactions
- Health Systems, Economic Evaluations, Quality of Life
- Maternal Mental Health During Pregnancy and Postpartum
- Pharmacological Effects and Toxicity Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Lung Cancer Treatments and Mutations
- Pharmaceutical Economics and Policy
- Artificial Intelligence in Healthcare
- Electrolyte and hormonal disorders
- Temporomandibular Joint Disorders
- Bacterial Identification and Susceptibility Testing
- Homicide, Infanticide, and Child Abuse
- HER2/EGFR in Cancer Research
- Nosocomial Infections in ICU
- Opioid Use Disorder Treatment
- Clinical practice guidelines implementation
- Antibiotic Use and Resistance
- Inflammatory mediators and NSAID effects
Meijo University
2016-2025
Iwate Medical University
2006-2008
Nara University
2002
Early treatment of disseminated intravascular coagulation (DIC) can be associated with improved patient outcomes. The Japanese Ministry Health and Welfare (JMHW) the International Society on Thrombosis Haemostasis (ISTH) criteria are most specific for diagnosis septic DIC. revised Association Acute Medicine (JAAM) able to diagnose sepsis-induced DIC in early stage. Recombinant human soluble thrombomodulin (rhTM) has recently been used treating Previous studies have shown a benefit using rhTM...
Abstract Introduction The spontaneous adverse drug reaction (ADR) reporting system plays an important role in pharmacovigilance by providing information from clinical settings the postmarketing environment. Japanese Adverse Drug Event Report (JADER) database contains a portion of ADR reports, and no previous study has described quality or characteristics reports JADER. Objective aim this was to identify JADER evaluate contained using documentation‐grading scheme developed World Health...
There is limited research regarding the use of glaucoma medicines during pregnancy. Prostaglandins contract uterine smooth muscle; however, it not clear whether prostaglandin eye drops are associated with pregnancy loss in pregnant women. We conducted a pharmacovigilance study using spontaneous report databases from Japan and USA to evaluate association between The Japanese Adverse Drug Event Report database Food Administration Reporting System were used for analysis. Disproportionality...
Objectives: Intraocular administration of vascular endothelial growth factor (VEGF) inhibitors may be associated with pregnancy loss. However, little is known about intraocular anti-VEGF therapy during pregnancy. Here, we conducted a pharmacovigilance study using spontaneous reporting database to evaluate the relationship between VEGF and Methods: We used JAPIC AERS which composed Food Drug Administration Adverse Event Reporting System (FAERS) dataset preprocessed by Japan Pharmaceutical...
Abstract Background There are no reports on investigations of the characteristics adverse drug reaction (ADR) for pediatric patients in Japanese Adverse Drug Event Report database (JADER) and utility safety surveillance these patients. Method We aimed to evaluate ADR JADER. used spontaneous included JADER since April 1, 2004, December 31, 2017, which was downloaded 2018. In a total 504,407 reports, number 386,400 (76.6%), 37,534 (7.4%) were unknown age reports. After extraction 27,800...
In the rehabilitation ward, many elderly patients require continuous use of medication after a stroke or bone fracture, even discharge. They are encouraged to self-manage their medications from time admission. Medication errors, such as missed dose incorrect administered can worsen conditions, resulting in recurrent strokes, fractures, adverse effects. The study was aimed identify risk factors, and prescription, contributing errors self-management medication.This conducted on who...
Opioids are widely used for the treatment of moderate/severe pain in cancer and noncancer patients. In this study, we searched safety signals a wide variety opioid-related adverse events (AEs) elderly patients by disproportionality analysis using Japanese Adverse Drug Event Report (JADER) database. Data from JADER database April 2004 to May 2018 were obtained Pharmaceuticals Medical Devices Agency website. Safety signal detection AEs was defined relative reporting odds ratio (ROR). Among...
The aim of this study was to prevent drug-related medication errors in the operating room by clarifying association between error category with related drugs and contributing factors.We used data from Japan Council for Quality Health Care's open database on web. We researched category, drugs, factors. classified each into case groups other categories control groups. compared factors 2 using multivariate logistic regression analysis factors.The total number analyzed cases 541. Incorrect dose...
Safety information regarding drug use during pregnancy is insufficient. The present study aimed to establish an optimal signal detection method identify adverse reactions in pregnant women and evaluate the Japanese Adverse Drug Event Report (JADER) database between April 2004 November 2014. We identified reports on using Standardised MedDRA Queries. calculated proportional reporting ratio (PRR) odds (ROR) of risk factors for two known risks antithyroid drugs methimazole (MMI) embryopathy,...
Recent developments have enabled daily accumulated medical information to be converted into big data, and new evidence is expected created using databases various open data sources. Database research was actively conducted in the coronavirus disease 2019 (COVID-19) pandemic for a disease. Conversely, term "infodemic" has emerged become social problem. Multiple posts on networking services (SNS) overly stirred up safety concerns about COVID-19 vaccines based analysis results of Vaccine...
Purpose: Spontaneous adverse drug reaction reporting is the foundation of postmarketing safety monitoring. The present study aimed to analyze and clarify quality characteristics Japanese Adverse Drug Event Report database (JADER) using World Health Organization (WHO) documentation grading scheme vigiGrade completeness score. reports were described both schemes simultaneously. way proper use these two was explored. Methods: WHO score applied same dataset (JADER202001 dataset). Reports...
Purpose In order to detect cancer therapeutics-related cardiac dysfunction (CTRCD) early, we identified which drugs were be monitored using signal detection and the package insert, created applied a protocol address this. Methods Adverse event data recorded in Japanese Drug Event Report (JADER) database between April 2004 January 2018 used. Among small molecule tyrosine kinase inhibitors that are not described serious side-effects section of insert despite detection, with severe background...
Little research has been published on the influence of deferasirox (DFX) (an iron chelating agent), or its use concomitantly with other drugs and acute renal dysfunction. We used signal detection to determine risk failure associated DFX concomitant drug using Japanese Adverse Drug Event Report database (JADER). When proportional reporting ratio (PRR) as an evaluation index, following were found by detection: DFX-cyclosporin A (CyA) (risk use: 2.53); DFX-loxoprofen sodium 2.48);...
高齢化や医療の高度化による医療費の増大は,日本の国民皆保険制度上の課題となっている。日本では,死期に近づくと医療資源の消費が増加することが報告されている。また,病院療養と比べて在宅療養では医療費が少ない可能性が示唆されているが,実証報告は限定的であり,在宅療養の費用対効果に関するエビデンスは必ずしも明らかではない。本研究では,終末期がん患者において在宅療養と病院療養にかかる費用とQOLを明らかにすることを目的に調査を行った。
Abstract Objective To evaluate the association between exposure to atypical antipsychotics during pregnancy and risk of miscarriage. Material Methods This nested case–control study used a large Japanese administrative database. Pregnancy onset outcomes were estimated using previously reported algorithms, classifying cases as women becoming pregnant 2013 2022 ending in Controls randomly selected from entire cohort by risk‐set sampling with replacement individually matched (3:1). The...
The present study aimed to describe the trends and characteristics of adverse events following immunization (AEFI) reporting for children in Japanese Adverse Drug Event Report database (JADER). We used 6280 AEFI reports aged <19 years among 504,407 ADR included JADER from 2004 2017. number gradually increased <10 was highest 2011 10–19 years. suspected vaccines per report after percentage “death” “did not recover” as outcomes reported were 4.3% 3.7% 0.2% 21.1% years, respectively. most...
Among Japanese pharmacists, there is a gap in their commitment to self-improvement and possible ability identify solve problems. However, the factors causing this situation have not yet been clarified. This study was conducted that influence abilities of pharmacists problems, which are skills considered essential for profession. A prior history presenting at academic conferences set as surrogate outcome clarify whether having experience affects factors.A nationwide internet-based survey...
Abstract Background The number of medications, administrations per day, dosing frequency on indicated and medication from multiple prescriptions are the factors prone to errors in self-management that have been previously reported. However, whether pharmacists actually intervene affect error occurrences is unclear. Therefore, we conducted this study clarify these issues. Method This included patients who underwent rehabilitation ward Higashinagoya National Hospital. From April 2019 March...
自発報告は市販後の医薬品安全性監視において重要な情報源である．日本では 2012 年に Japanese Adverse Drug Event Report database (JADER) が公開されており，以来，データマイニング手法を用いた数多くの学会発表，論文投稿が行われている．自発報告は，一般的に過少報告，分母情報の欠如，報告バイアスの影響など種々の限界点を有しており，これらは JADER にも当てはまる．また，JADER では主に重篤な症例が集積されていることや，依頼に基づく報告も含まれていることなど，自発報告が収集されている制度的背景も影響をもたらす．統計学的に検出されたシグナルは必ずしも医薬品と有害事象に因果関係があることを意味するものではなく，検出されたシグナルには慎重な解釈が必要となる．しかしながら，留意すべき限界点について考えずに用いられているという指摘の声があがっている．