A5081501694- interferon and immune responses
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- NF-κB Signaling Pathways
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- RNA regulation and disease
- DNA Repair Mechanisms
- Heat shock proteins research
- Signaling Pathways in Disease
- Enzyme Structure and Function
- Epigenetics and DNA Methylation
- Viral Infections and Immunology Research
- Cancer-related gene regulation
- RNA Research and Splicing
- Endoplasmic Reticulum Stress and Disease
Inserm
2018-2022
Université de Bourgogne
2017-2022
La Ligue Contre le Cancer
2019-2022
Université Bourgogne Franche-Comté
2018-2022
Centre de recherche Translationnelle en Médecine moléculaire
2018-2019
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2018
Abstract The E2F transcription factor 1 is subtly regulated along the cell cycle progression and in response to DNA damage by post-translational modifications. Here, we demonstrated that E3-ubiquitin ligase cellular inhibitor of apoptosis (cIAP1) increases E2F1 K63-poly-ubiquitination on lysine residue 161/164 cluster, which associated with transcriptional stability activity. Mutation these residues completely abrogates binding CCNE , TP73 APAF1 promoters, thus inhibiting activation genes...
The cellular inhibitor of apoptosis 1 (cIAP1) is an E3-ubiquitin ligase that regulates cell signaling pathways involved in fundamental processes including death, proliferation, differentiation and inflammation. It recruits ubiquitination substrates thanks to the presence three baculoviral IAP repeat (BIR) domains at its N-terminal extremity. We previously demonstrated cIAP1 promoted E2 factor (E2F1) transcription factor. Moreover, we showed was required for E2F1 stabilization during S phase...
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