A5011059042- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Prostate Cancer Diagnosis and Treatment
- Immune cells in cancer
- Effects of Radiation Exposure
- Cell death mechanisms and regulation
- Heat shock proteins research
- Nanoplatforms for cancer theranostics
- Prostate Cancer Treatment and Research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Endoplasmic Reticulum Stress and Disease
- Immune Response and Inflammation
- Nanoparticle-Based Drug Delivery
- CAR-T cell therapy research
- Head and Neck Cancer Studies
- Colorectal and Anal Carcinomas
- Glioma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- NF-κB Signaling Pathways
- Cancer-related Molecular Pathways
- Lung Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
Inserm
2007-2025
Centre Georges François Leclerc
2016-2025
Laboratoire de Recherche Vasculaire Translationnelle
2025
Université de Bourgogne
2008-2022
Centre de recherche Translationnelle en Médecine moléculaire
2020
Centre National de la Recherche Scientifique
2013
Université Libre de Bruxelles
2004-2005
Délégation Centre-Est
2000-2003
Université de Lorraine
2002
Centre de Recherche en Automatique de Nancy
2001
<h3>Purpose/objective</h3> Radiotherapy (RT) induces an immunogenic antitumor response, but also some immunosuppressive barriers. It remains unclear how different fractionation protocols can modulate the immune microenvironment. Clinical studies are ongoing to evaluate checkpoint inhibitors (ICI) in association with RT. However, only few trials aim optimize RT improve efficacy of these associations. Here we sought characterize effect on response a view associating them ICI....
Polydopamine (pDA)-modified iron oxide core-shell nanoparticles (IONPs) are developed and designed as nanovectors of drugs. Reactive quinone pDA enhances the binding efficiency various biomolecules for targeted delivery. Glutathione disulfide (GSSG), an abundant thiol species in cytoplasm, was immobilized on pDA-IONP surface. It serves a cellular trigger to release drug from providing efficient platform delivery system. Additionally, GSSG surface further modified form S-nitrosoglutathione...
Abstract Radiotherapy delivered using photons induces an immune response that leads to modulation of the tumor microenvironment. Clinical studies are ongoing evaluate checkpoint inhibitors in association with photon radiotherapy. At present, there is no publication on radio-induced after proton therapy. Balb/c mice bearing subcutaneous CT26 colon tumors were irradiated by a single fraction 16.4 Gy beam extracted from TR24 cyclotron. RNA sequencing analysis was assessed at 3 days...
Stress-inducible HSP27 protects cells from death through various mechanisms. We have recently demonstrated that can also enhance the degradation of some proteins proteasomal pathway. Here, we show one these is cyclin-dependent kinase (Cdk) inhibitor p27Kip1. The ubiquitination and this protein favors progression cell cycle was previously shown to involve either a Skp2-dependent mechanism,i.e., at S-/G2-transition, or KPC (Kip1 ubiquitination-promoting complex)-dependent mechanism, i.e.,at...
Abstract Subcutaneous (SC) administration of monoclonal antibodies (mAbs) is a proven strategy for improving therapeutic outcomes and patient compliance. The current FDA‐/EMA‐approved enzymatic approach, utilizing recombinant human hyaluronidase (rHuPH20) to enhance mAbs SC delivery, involves degrading the extracellular matrix's hyaluronate increase tissue permeability. However, this method lacks tunable release properties, requiring individual optimization each mAb. Seeking alternatives,...
p53 tumour-suppressor gene is involved in cell growth control, arrest and apoptosis. Nevertheless cycle apoptosis induction can be observed p53-defective cells after exposure to DNA-damaging agents such as 5-fluorouracil (5-FU) suggesting the importance of alternative pathways via p53-independent mechanisms. In order establish relationship between status, arrest, Bcl-2/Bax regulation 5-FU sensitivity, we examined mRNA protein expression functionality wild-type (wt) mutant (mt) lines. were...
Introduction: Some studies have suggested that baseline tumor-infiltrating-lymphocytes (TILs), such as CD8+ and FoxP3+ T-cells, may be associated with a better prognosis in colorectal cancer. We sought to investigate modulation of the immune response by preoperative radiotherapy (preopRT) its impact on survival locally advanced rectal cancer (LARC). Materials & Methods: analyzed data for 237 patients LARC who received RT. Density TILS (CD8+ FoxP3+) intraepithelial (iTILs) stromal...
Nanohybrids based on titanate nanotubes (TiONts) were developed to fight prostate cancer by intratumoral (IT) injection, and particular attention was paid their step-by-step synthesis. TiONts synthesized a hydrothermal process. To develop the customengineered nanohybrids, surface of coated beforehand with siloxane (APTES), coupled both dithiolated diethylenetriaminepentaacetic acidmodified gold nanoparticles (Au@DTDTPA NPs) heterobifunctional polymer (PEG3000) significantly improve...
Nanoparticle (NP) surface functionalization with proteins, including monoclonal antibodies (mAbs), mAb fragments, and various peptides, has emerged as a promising strategy to enhance tumor targeting specificity immune cell interaction. However, these methods often rely on complex chemistry suffer from batch-dependent outcomes, primarily due limited control over the protein orientation quantity NP surfaces. To address challenges, novel approach based supramolecular assembly of two peptides is...