A5057704237- Chemotherapy-induced cardiotoxicity and mitigation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Fibrosis and Remodeling
- Congenital heart defects research
- S100 Proteins and Annexins
- Advanced Glycation End Products research
- Parathyroid Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Electron Spin Resonance Studies
- Estrogen and related hormone effects
- Fibroblast Growth Factor Research
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Drug Delivery Systems
- Tissue Engineering and Regenerative Medicine
- Polymer Surface Interaction Studies
- Neurological Disease Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Immunotherapy and Immune Responses
- Ferrocene Chemistry and Applications
- Graphene and Nanomaterials Applications
- Connective tissue disorders research
- Advanced Biosensing Techniques and Applications
International Drug Development
2023-2025
Institut Polytechnique de Bordeaux
2023-2025
Institut de Cancérologie Strasbourg
2023-2025
La Ligue Contre le Cancer
2024-2025
Université de Versailles Saint-Quentin-en-Yvelines
2022-2023
Université Paris-Saclay
2022-2023
Inserm
2022
École Supérieure de Biotechnologie de Strasbourg
2013-2020
Université de Strasbourg
2013-2020
Centre National de la Recherche Scientifique
2013-2020
Low-grade inflammation may contribute to obesity-related insulin resistance and has been associated with increased risk of type 2 diabetes mellitus. The present study evaluated whether treatment salsalate, a traditional anti-inflammatory medication, would improve action in obese non-diabetic individuals. was randomised, double-blind, placebo-controlled, parallel trial conducted at the inpatient clinical research unit NIDKK (Phoenix, AZ, USA). Participants were 54 adults (18 45 years age) BMI...
Prokineticins are angiogenic hormones that activate two G protein-coupled receptors: PKR1 and PKR2. has emerged as a critical mediator of cardiovascular homeostasis cardioprotection. Identification non-peptide agonists contribute to myocardial repair collateral vessel growth hold promises for treatment heart diseases. Through combination in silico studies, medicinal chemistry, pharmacological profiling approaches, we designed, synthesized, characterized the first agonists, demonstrating...
Abstract Subcutaneous (SC) administration of monoclonal antibodies (mAbs) is a proven strategy for improving therapeutic outcomes and patient compliance. The current FDA‐/EMA‐approved enzymatic approach, utilizing recombinant human hyaluronidase (rHuPH20) to enhance mAbs SC delivery, involves degrading the extracellular matrix's hyaluronate increase tissue permeability. However, this method lacks tunable release properties, requiring individual optimization each mAb. Seeking alternatives,...
The clinical use of doxorubicin for the treatment cancer is limited by its cardiotoxicity. Flavaglines are natural products that have both potent anticancer and cardioprotective properties. A synthetic analog flavaglines, FL3, efficiently protects mice from cardiotoxicity doxorubicin. mechanism underlying this effect has yet to be elucidated.Here, we show FL3 binds scaffold proteins prohibitins (PHBs) thus promotes their translocation mitochondria in H9c2 cardiomyocytes. induces...
Nanoparticle (NP) surface functionalization with proteins, including monoclonal antibodies (mAbs), mAb fragments, and various peptides, has emerged as a promising strategy to enhance tumor targeting specificity immune cell interaction. However, these methods often rely on complex chemistry suffer from batch-dependent outcomes, primarily due limited control over the protein orientation quantity NP surfaces. To address challenges, novel approach based supramolecular assembly of two peptides is...
Orientation and steric hindrance decrease the efficiency for an antibody to attach its specific receptor. Giving flexibility a dendronized peptide through small PEG fragment increases peptides affinity cellular receptors.
Abstract The epicardium plays an essential role in coronary artery formation and myocardial development. However, signals controlling the developing epicardial-mesenchymal transition (EMT) normal diseased adult heart are studied less rigorously. Here we investigated of angiogenic hormone, prokineticin-2 its receptor PKR1 heart. Genetic ablation leads to partial embryonic postnatal lethality with abnormal Cardiac developmental defects manifested stage as ischemic cardiomyopathy systolic...
This study investigated how different concentrations of doxorubicin (DOX) can affect the function cardiac cells. also examined whether activation prokineticin receptor (PKR)-1 by a nonpeptide agonist, IS20, prevents DOX-induced cardiovascular toxicity in mouse models.High prevalence heart failure during and following cancer treatments remains subject intense research therapeutic interest.This used cultured cardiomyocytes, endothelial cells (ECs), epicardium-derived progenitor (EDPCs) for...
Spinal cord injuries involve a primary injury that can lead to permanent loss of function and secondary associated with pathologic inflammatory processes. Extracellular traps are extracellular structures expressed by immune cells primarily composed chromatin, granular enzymes histones. known induce tissue damage when overexpressed could be in the occurrence damage. In present study, we used flow cytometry demonstrate at 1 day following C2 spinal lateral hemisection male Swiss mice, resident...
Subcutaneous Administration of Monoclonal Antibodies Alexandre Detappe and co-workers developed a novel chitosan-based hydrogel formulation for minute-mixing with clinically approved intravenous-based monoclonal antibodies to reformulate them subcutaneous administration, the preferred method administration patients. They validated this innovative in both mice nonhuman primates, confirming biocompatibility, biodegradability, controlled sustained release properties. More details can be found...
A dog with immune‐mediated haemolytic anaemia developed transient hyperglycaemia and glucosuria requiring insulin therapy in association prednisone cyclosporin therapy. Following short‐term A, the remained on but required no further for 12 weeks, at which time became permanently diabetic. We hypothesise that contributed to resistance a prediabetic suboptimal endogenous concentration degree of decreased when was discontinued.
Fibroblast Growth Factor 23 (FGF23) is well documented as a crucial player in the systemic regulation of phosphate homeostasis. Moreover, loss-of-function experiments have revealed that FGF23 also has phosphate-independent and local impact on skeletogenesis. Here, we used ATDC5 cell line to investigate expression role it may play locally during differentiation these cells.ATDC5 cells were differentiated presence insulin, treated with recombinant (rFGF23), inorganic (Pi) and/or PD173074, an...
Severe inflammation via innate immune system activation causes organ dysfunction. Among these, the central nervous (CNS) is particularly affected by encephalopathies. These symptoms are associated with of microglia and a potential infiltration leukocytes. cells have recently been discovered to ability produce extracellular traps (ETs). While these components capture destroy pathogens, deleterious effects occur such as reduced neuronal excitability correlated excessive ETs production. In this...
Prokineticins are angiogenic hormones that activate two G protein-coupled receptors: PKR1 and PKR2. has emerged as a critical mediator of cardiovascular homeostasis cardioprotection. Identification non-peptide agonists contribute to myocardial repair collateral vessel growth hold promises for treatment heart diseases. Through combination in silico studies, medicinal chemistry, pharmacological profiling approaches, we designed, synthesized, characterized the first agonists, demonstrating...
Sepsis is characterized by a dysregulated host response to an infection, potentially leading fatal organ dysfunctions. Among these organs, the central nervous system (CNS) particularly affected with encephalopathies associated or not chronic disabling pain. These symptoms are caused broad neuroinflammation activation of resident microglia cells and infiltration leukocytes, especially neutrophils. immune have ability produce extracellular traps (ETs) in blood tissues. components composed...
Sepsis is one of the leading causes death worldwide, and no therapy available other than intensive care treatments. Drug development attempts have mainly focused on controlling inflammation or treating dysfunction, without significant improvement in last decades. Recently, interest has emerged β1-adrenergic blockade, which proved beneficial to both parameters. Unfortunately, specific underlying mechanisms not been addressed yet. Our study aimed investigate mice (adult Swiss male, 30-45g)...