A5063344770- Cardiac, Anesthesia and Surgical Outcomes
- Phagocytosis and Immune Regulation
- Peripheral Artery Disease Management
- Anesthesia and Pain Management
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Vascular Procedures and Complications
- Anesthesia and Sedative Agents
- Cerebrovascular and Carotid Artery Diseases
- Neuropeptides and Animal Physiology
- Music Therapy and Health
- Cancer, Stress, Anesthesia, and Immune Response
- Erythrocyte Function and Pathophysiology
- Receptor Mechanisms and Signaling
- CAR-T cell therapy research
- Musculoskeletal pain and rehabilitation
- Cardiovascular Health and Disease Prevention
- Nanoplatforms for cancer theranostics
- Art Therapy and Mental Health
- Immunotherapy and Immune Responses
- Pain Management and Treatment
- Circular RNAs in diseases
- Hemodynamic Monitoring and Therapy
- Epigenetics and DNA Methylation
- Diagnosis and Treatment of Venous Diseases
Pennsylvania State University
2024-2025
Kettering University
2022-2025
Memorial Sloan Kettering Cancer Center
2022-2025
Penn State Milton S. Hershey Medical Center
2023-2025
Office of Education
2024
Swim Across America
2022
Parker Institute for Cancer Immunotherapy
2022
The Graduate Center, CUNY
2019
CUNY Advanced Science Research Center
2019
Abstract Introduction: Multiple suppressive mechanisms within the tumor microenvironment (TME) contribute to blunt anti-tumor T cell responses. Among them, tumor-associated cells have been phenotypically described be functionally exhausted (or dysfunctional), reflecting a hyporesponsive state of chronically stimulated that express multiple inhibitory receptors immune checkpoint molecules), such as programmed death protein 1 (PD-1), T-cell immunoglobulin and mucin-domain containing-3 (TIM-3),...
In addition to playing a major role in tumor cell biology, p53 generates microenvironment that promotes antitumor immune surveillance via tumor-associated macrophages. We examined whether increasing signaling the influences T immunity. Our findings indicate increased induced either pharmacologically with APR-246 (eprenetapopt) or p53-overexpressing transgenic mice can disinhibit immunity and augment efficacy of checkpoint blockade. demonstrated expression macrophages induces canonical...
Abstract Introduction: Melanoma patient survival rates have significantly improved recently owing to the development of both targeted therapies and immunotherapies. However, there are still around 50% patients relapse. The limited response immunotherapies global rise in melanoma incidence, with 290,000 cases newly diagnosed each year, highlight need for identifying new biomarkers, modulatory pathways, risk factors development. Earlier studies characterized that aberrant expression CD47...
Amputation is an undesirable outcome of peripheral arterial disease (PAD) that affects both the mobility and broader lifestyle patient. Prior studies have shown lower extremity amputation associated with increased rates postoperative diagnosis depression. However, these are primarily single-center do not include analysis over various timepoints. The objective this study was to ascertain extent time- dependent association between development This information will allow vascular surgeons make...
Patients suffering from peripheral artery disease are commonly prescribed gabapentinoids (GBPs; gabapentin and pregabalin) for pain management. In this study, we investigate the impact of preoperative use GBPs on postoperative risk opioid-related disorders in patients with undergoing lower extremity bypass operation. This is a retrospective propensity-score-matched analysis TriNetX, multicenter population-level database. Two study groups were constituted based history GBPs. before excluded...
Abstract Canonical p53-activated pathways can influence a microenvironment that promotes antitumor immune surveillance via tumor-associated macrophages (TAMs). We examined whether p53 activity in the tumor (TME) influences immunity and show signaling induced pharmacologically with APR-246 (eprenetapopt) augment efficacy of checkpoint blockade (ICB) preclinical models, strategy is also being tested patients (NCT04383938). first investigated effects combining ICB wildtype C57BL6 (B6) mice...
Abstract Multiple suppressive mechanisms within the tumor microenvironment (TME) are capable of blunting anti-tumor T cell responses. These include engagement inhibitory receptors expressed in tumor-associated, exhausted CD8 cells, such as programmed death protein 1 (PD-1), T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), lymphocyte-activation gene 3 (LAG-3), 2B4 (also known CD244), immunoreceptor with Ig ITIM domains (TIGIT). While immune checkpoint blockade therapies aimed at...
<h3>Background</h3> The expression and function of signal-regulatory protein alpha (SIRPα; also known as PTPNS1, SHPS-1, CD172a, P84) is well characterized in myeloid effector cells (e.g.: monocytes, macrophages, neutrophils, dendritic microglia),<sup>1-3</sup> where it contributes to tissue homeostasis regulation erythrocyte, platelet, hematopoietic stem (HSC). In addition, regulates synaptic pruning during neuronal development.<sup>4-7</sup> Another important feature SIRPα that, upon...