A5074339362- Memory and Neural Mechanisms
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Carcinogens and Genotoxicity Assessment
- Autism Spectrum Disorder Research
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Creativity in Education and Neuroscience
- Stress Responses and Cortisol
- Cannabis and Cannabinoid Research
- Aluminum toxicity and tolerance in plants and animals
- Health, Environment, Cognitive Aging
- Neuroendocrine regulation and behavior
- Schizophrenia research and treatment
- Neuroscience, Education and Cognitive Function
- Gut microbiota and health
- Biological Research and Disease Studies
- Phosphodiesterase function and regulation
- Neurogenesis and neuroplasticity mechanisms
- Neurotransmitter Receptor Influence on Behavior
- DNA Repair Mechanisms
- 14-3-3 protein interactions
- Nerve injury and regeneration
University of Tennessee Health Science Center
2016-2021
Boehringer Ingelheim (Germany)
2014-2015
Laboratoire de Neurosciences Cognitives et Adaptatives
2013-2015
Université de Strasbourg
2014-2015
Centre National de la Recherche Scientifique
2014-2015
Alzheimer’s disease (AD), a progressive neurodegenerative disorder characterized by memory loss and cognitive decline, is major cause of death disability among the older population. Despite decades scientific research, underlying etiological triggers are unknown. Recent studies suggested that gut microbiota can influence AD progression; however, potential mechanisms linking with pathogenesis remain obscure. In present study, we provided mechanistic link between dysbiotic neuroinflammation...
Abstract Reduced promoter IV-driven expression of brain-derived neurotrophic factor (BDNF) is implicated in stress and major depression. We previously reported that defective IV (KIV) caused depression-like behavior young adult mice, which was reversed more effectively by enriched environment treatment (EET) than antidepressants. The effects IV-BDNF deficiency EET over the life stages remain unknown. Since early-life development (ED) involves dynamic epigenetic processes, we hypothesized...
Although many clinical pathological states are now detectable using imaging and biochemical analyses, neuropsychological tests often considered as valuable complementary approaches to confirm diagnosis, especially for disorders like Alzheimer’s or Parkinson’s disease, schizophrenia. The touchscreen-based automated test battery, which was introduced two decades ago in humans assess cognitive functions, has recently been successfully back-translated monkeys rodents. We focused on optimizing...
Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by cognitive dysfunctions associated with progressive atrophy of specific brain areas. Patients' post-mortem analyses reveal the presence two main histopathological hallmarks: extracellular amyloid (Aß) plaques and intracellular neurofibrillary tangles (NFTs). One hypothesis has postulated that Aß along various soluble forms (oligomers) resulting from its aggregation would be mainly responsible for appearance...